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The map label for this gene is 74316063

Identifier: 74316063

GI number: 74316063

Start: 46250

End: 46630

Strand: Reverse

Name: 74316063

Synonym: Tbd_0045

Alternate gene names: NA

Gene position: 46630-46250 (Counterclockwise)

Preceding gene: 74316064

Following gene: 74316062

Centisome position: 1.6

GC content: 64.3

Gene sequence:

>381_bases
ATGGATATCGTCTCGATTGACCACGTGGTGCTGACCGTCCGCGACATCCGCGCGAGCGTGGCCTTTTACACGCGGGTGCT
GGGCATGCAGGAGGTGATGTTCGGCGGCGATCGACGCGCGTTGGCATTCGGGCACAGCAAATTGAATCTCCATCAAGCCG
GCCGCGAGCTCGAGCCGAAAGCGGCTCGCGCGACGCCTGGCGCCGTCGATCTCTGCCTGCTCGCGCACACGCCGATCGCA
GAGATCATTCGCCATCTGGCCACGCATGGCGTTACCGTCGAGGAAGGGCCGGTCGAACGAACCGGCGCACAGGGGCCGAT
CCTCTCGGTGTATGTGCGCGACCCCGACGGCAACCTGATCGAACTGTCCAATCCACGCTGA

Upstream 100 bases:

>100_bases
GCCGCTCGCGCCCGCGCTCGCGACGCTGCACGCCCGCCTCAAGCAACGCTTCGACCCGCGCGGCATCCTGAACCGCGGCC
GCCTGTACCCGGACTTCTGA

Downstream 100 bases:

>100_bases
CATGCAGACCCATCTCGCCGCCCCCTTCCGCGAGACCTCCGAAGGCGAGGTCGCCGAGCGCATCCTGCGCAATTGCGTGC
ACTGCGGCTTCTGTCTTGCG

Product: ring-cleaving dioxygenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MDIVSIDHVVLTVRDIRASVAFYTRVLGMQEVMFGGDRRALAFGHSKLNLHQAGRELEPKAARATPGAVDLCLLAHTPIA
EIIRHLATHGVTVEEGPVERTGAQGPILSVYVRDPDGNLIELSNPR

Sequences:

>Translated_126_residues
MDIVSIDHVVLTVRDIRASVAFYTRVLGMQEVMFGGDRRALAFGHSKLNLHQAGRELEPKAARATPGAVDLCLLAHTPIA
EIIRHLATHGVTVEEGPVERTGAQGPILSVYVRDPDGNLIELSNPR
>Mature_126_residues
MDIVSIDHVVLTVRDIRASVAFYTRVLGMQEVMFGGDRRALAFGHSKLNLHQAGRELEPKAARATPGAVDLCLLAHTPIA
EIIRHLATHGVTVEEGPVERTGAQGPILSVYVRDPDGNLIELSNPR

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=122, Percent_Identity=53.2786885245902, Blast_Score=155, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 13685; Mature: 13685

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVSIDHVVLTVRDIRASVAFYTRVLGMQEVMFGGDRRALAFGHSKLNLHQAGRELEPK
CCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCC
AARATPGAVDLCLLAHTPIAEIIRHLATHGVTVEEGPVERTGAQGPILSVYVRDPDGNLI
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEE
ELSNPR
EECCCC
>Mature Secondary Structure
MDIVSIDHVVLTVRDIRASVAFYTRVLGMQEVMFGGDRRALAFGHSKLNLHQAGRELEPK
CCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCC
AARATPGAVDLCLLAHTPIAEIIRHLATHGVTVEEGPVERTGAQGPILSVYVRDPDGNLI
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEE
ELSNPR
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]