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The map label for this gene is ccmE

Identifier: 73538594

GI number: 73538594

Start: 1469224

End: 1469703

Strand: Direct

Name: ccmE

Synonym: Reut_B4769

Alternate gene names: 73538594

Gene position: 1469224-1469703 (Clockwise)

Preceding gene: 73538593

Following gene: 73538595

Centisome position: 53.89

GC content: 67.92

Gene sequence:

>480_bases
ATGACGCCGCGCCAGCGCCGCCTGGGCATGCTGCTGGCCGCGCTGGCCTGCGCGGGCATCGCGCTCGCGCTCGTGCTCAA
TGCATTTCGCTCGAACCTCGTGTTCTTCTTCAGCCCGAGCCAGGTTGCCGCGCACGAGGCGCCGGCTTCGCGAAGCTTCC
GGCTCGGCGGTCTCGTCGCGCCCGGCTCCATTCGCCGTGAAGGCGACGGCATGACCGTCCGCTTCATCGTCACCGACAAG
GCGCGCGAAGTTCCGGTGGTCTATCGCGGCCTGTTGCCGGACCTGTTCCGCGAAGGCAAGGGCGTGGTCGCGCGTGGCAC
GCTAGACCGCAGCGGCACCTTCGTCGCCAGCGAGGTACTGGCCAAGCACGATGAAAACTACATGCCGCCCGAAGCCGCCG
ATGCGCTGAAGCAGGCGGAACAGGTCAACCGCCGCATGGCGAGCCAGTTAGCGGAAGGCGAACGGGAGACGCAGCGATGA

Upstream 100 bases:

>100_bases
ATATTGCCGGCGCATTCGGCGTGGCATTCGCGCTGATCGGCGTGGAACTTGTCCTGCTGGCGCGGCGTAGCCGTGCCAGC
GCCACACGGCACACGCCGCG

Downstream 100 bases:

>100_bases
TCCCGGAACTCGGACACTTTGCATTGATCGTGGCGCTGTTGGCCGCCATGATGCAGGCTCTGCTGCCGCTGGCCGGCGCG
GCGCGTGCCAATGCGGCGTG

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVAPGSIRREGDGMTVRFIVTDK
AREVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR

Sequences:

>Translated_159_residues
MTPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVAPGSIRREGDGMTVRFIVTDK
AREVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR
>Mature_158_residues
TPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVAPGSIRREGDGMTVRFIVTDKA
REVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVLAKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=151, Percent_Identity=42.3841059602649, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_CUPPJ (Q46RW7)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_298961.1
- ProteinModelPortal:   Q46RW7
- SMR:   Q46RW7
- GeneID:   3613325
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B4769
- NMPDR:   fig|264198.3.peg.5702
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13254
- BioCyc:   REUT264198:REUT_B4769-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17339; Mature: 17208

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0x178e3540)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCCCCCEECCCEEC
PGSIRREGDGMTVRFIVTDKAREVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVL
CCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
AKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TPRQRRLGMLLAALACAGIALALVLNAFRSNLVFFFSPSQVAAHEAPASRSFRLGGLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCCCCCEECCCEEC
PGSIRREGDGMTVRFIVTDKAREVPVVYRGLLPDLFREGKGVVARGTLDRSGTFVASEVL
CCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
AKHDENYMPPEAADALKQAEQVNRRMASQLAEGERETQR
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA