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The map label for this gene is hemE [H]

Identifier: 73543024

GI number: 73543024

Start: 3659911

End: 3661002

Strand: Reverse

Name: hemE [H]

Synonym: Reut_A3342

Alternate gene names: 73543024

Gene position: 3661002-3659911 (Counterclockwise)

Preceding gene: 73543025

Following gene: 73543023

Centisome position: 96.18

GC content: 66.94

Gene sequence:

>1092_bases
ATGACTGCACTGCAGAACGACACTTTCCTGCGCGCACTGCGCCGGCAGCCGACCGAATACACGCCGCTGTGGCTGATGCG
CCAGGCAGGCCGCTACCTGCCTGAGTACAACGCCACGCGCGCGCGCGCGGGCAGCTTTCTGGGCCTGGCCAAAAATCCAG
CCTATGCCACCGAAGTGACGCTGCAGCCGCTGGACCGCTATCCGCTGGACGCGGCCATCCTGTTCTCCGACATCCTGACC
GTGCCCGACGCCATGGGCCTCGGCCTGTCGTTTGCCCAGGGCGAAGGCCCGCGCTTCGCGCGGCCGCTGCGTACCGAAGC
CGACGTGCAGAAGCTTGCCGTGCCCGACATGGCATCACTGCAGTATGTGTTCGACGCCGTGGCCGAGATCCGCCGCGCGC
TGGTCCAGGACGGGCGCCAGCGCGTGCCGCTGATCGGCTTCTCGGGCAGCCCGTGGACGCTGGCTTGCTACATGGTCGAA
GGCGGCGGCTCGGACGACTTCCGCACGGTCAAGGCGATGATGTACGGCCGGCCGGACCTGATGCACCGCATCCTCGACAT
CAATGCGCAGGCGGTCAGCGAGTACCTGAATGCACAGATCGAGGCAGGCGCGCAGGCCGTCATGATCTTCGACACCTGGG
GCGGTGCGCTGGCTGACGGCATGTACCAGGCGTTCTCGCTGGCCTATATGCGCAAGGTACTCGCCGGCCTGAAGCGCGAG
CATGACGGACAGCAGATCCCCGCGATCGTCTTCACGAAGGGTGGCGGCCTGTGGCTGGAAGGCCTCGCCGACACCGGCGC
CGACGCCATTGGTTTGGACTGGACGGTCAACCTTGCGCAAGCGCGCCGACGCACCGGTGGCCGCGTGGCGCTGCAGGGCA
ATATCGATCCGACAGTGCTGTTCGCCCCCGAAGCGGCGATTCGGGAACAGGTGCGGGGCGTGCTCGACAGCTATGCGGCA
GCGGGCGGTAGCGACGGTCATGTGTTCAACCTCGGCCACGGTATTTCGCAGTTCACGCCCCCGGAAAGCGTGGCGGTGCT
CGTCGACGAAGTGCATCGCTATAGCCGCCAGCTGCGCACGTCGCAGGGCTGA

Upstream 100 bases:

>100_bases
CTGTTCGACGACGTCTAGCGGTCTGGTGCGCCGGCACTGTCGCATCAGGCGCCGGTGCGCGGCGGCCATCCCTTAGAATG
GCGGTCTTACGAGGATGACC

Downstream 100 bases:

>100_bases
AACACCGATATCCCGAAAGTACCGGCGTCATGCGCCGGTCATATTTTCCTCGCGGTGCAGCGATTTTGGCGCCAACGTCA
GCGGTGTCGCTGGAGGCGCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILT
VPDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKAMMYGRPDLMHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKRE
HDGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVLFAPEAAIREQVRGVLDSYAA
AGGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRTSQG

Sequences:

>Translated_363_residues
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILT
VPDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKAMMYGRPDLMHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKRE
HDGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVLFAPEAAIREQVRGVLDSYAA
AGGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRTSQG
>Mature_362_residues
TALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILTV
PDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASLQYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEG
GGSDDFRTVKAMMYGRPDLMHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKREH
DGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVLFAPEAAIREQVRGVLDSYAAA
GGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRTSQG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=363, Percent_Identity=45.7300275482094, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI2367337, Length=358, Percent_Identity=62.5698324022346, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320252, Length=360, Percent_Identity=38.6111111111111, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI221330099, Length=356, Percent_Identity=37.6404494382022, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI19921920, Length=356, Percent_Identity=37.6404494382022, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39596; Mature: 39464

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCEEEEE
LQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASL
ECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCHHHHHHHCCCCHHHH
QYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKAMMYGRPDL
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHH
MHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKRE
HHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HDGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVL
CCCCCCCEEEEECCCCEEEECCCCCCCCEECCCEEEEHHHHHHCCCCEEEEECCCCCEEE
FAPEAAIREQVRGVLDSYAAAGGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRT
ECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SQG
CCC
>Mature Secondary Structure 
TALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCEEEEE
LQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFARPLRTEADVQKLAVPDMASL
ECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCHHHHHHHCCCCHHHH
QYVFDAVAEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKAMMYGRPDL
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHH
MHRILDINAQAVSEYLNAQIEAGAQAVMIFDTWGGALADGMYQAFSLAYMRKVLAGLKRE
HHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HDGQQIPAIVFTKGGGLWLEGLADTGADAIGLDWTVNLAQARRRTGGRVALQGNIDPTVL
CCCCCCCEEEEECCCCEEEECCCCCCCCEECCCEEEEHHHHHHCCCCEEEEECCCCCEEE
FAPEAAIREQVRGVLDSYAAAGGSDGHVFNLGHGISQFTPPESVAVLVDEVHRYSRQLRT
ECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SQG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA