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The map label for this gene is ygfU [H]

Identifier: 73542756

GI number: 73542756

Start: 3381836

End: 3383227

Strand: Direct

Name: ygfU [H]

Synonym: Reut_A3072

Alternate gene names: 73542756

Gene position: 3381836-3383227 (Clockwise)

Preceding gene: 73542755

Following gene: 73542758

Centisome position: 88.84

GC content: 65.01

Gene sequence:

>1392_bases
ATGACCCCCAACCTGCAATCGCATGGGGCAGTCCCCGTGCATCCCGTCGACGAAGTTCTGCCCGCCCCGCGTCTGCTCGC
ATTGGGCCTGCAGCATGTGCTGGTGATGTATGCCGGCGCCATTGCCGTGCCGCTGATCGTTGGCGGCGCGCTCAAGCTGC
CCAAGGACCAGATCGCGTTCCTGATCGCCGCCGACCTGTTCTGCTGTGGCCTCGTGACGATGATCCAGAGCATCGGCATC
TGGAAAGTTGGCATCCGGCTGCCCGTCATGATGGGCGTGACCTTCACGGCCATCGCGCCGATCATCGCGACCGGTTCCAA
TCCCTCGCTCGGGCTGCCCGCCGTGTTCGGCGCGGTGATGCTCGCCGGCATTTTCACGTTCCTGGTGGCGCCATACGTCG
GCAAGATGGTGCGCTGGTTCCCGCCGGTGGTAACGGGCACCGTGGTGCTCGTGATCGGCATCTCGCTGATGCGTGTGGGC
ATCAACTGGGCTGCTGGCGGCAACCCGATGATCTCGACGCCCAACGGGCCCGTACCGAACCCGAACTTCGGCGTGCCGGT
CAACATCGCCATTGCCACGGTTGTGCTGCTGACGGTGCTGGCTCTGGTGGCGTTCGCCAAAGGATTTCTATGCAATGTCG
CCGTGCTGATCGGCATCCTGACCGGCTTCGCGATTGCGCTGTCGCTCGGCAAGGTCAGCTTCGACGGTCTCGCTGCGGCG
CACTGGGTGGAGCTGATCACGCCGTTCCATTTCGGCTGGCCGACCTTCGATCCGATGACGACTGTCACGCTGTGTGTGGT
GATGGTGGTGATCATGATCGAAGGCGTCGGGCAGTTCCTGGCCCTTGGCGAGATCGTCGGCCGGCCGGTGACCTGCGACG
ACCTGACACGCGGGCTGCGCGCTGACGGCGTCGGCGCGCTCGTCGGTGCGGTGTTCAACACGTTCACCTACACATCGTAT
GCGCAGAACGTCGGACTGGTGCAGGTCACTGGCGTGCGCAGCCGCTGGGTCTGCGCGACGGCCGGCGCGATCCTGGTCGT
GCTCGGCTGCCTGCCGAAGCTCGCGTTCTTCGCGGCGTCGATTCCGCAGTACGTGCTGGGCGGTGCCGCGCTCGTGATGT
TTGGCATGGTCGCGGCCACAGGCGTGCGCATCCTCGGCCATGTCGATTTCGTCGAGAACAAGAAGAACGCCTACATCGTC
GCGGTGAGCATCGCGCTCGGCATGATTCCGCTCGTGTCGGAGCGGTTCTTCTCGCAGATGCCGGAGCTGCTCGCCAAGTT
CTGCCAGAACGGCATCCTGCTCGGCACGCTGTCCGCGGTGCTGCTGAACGTGCTGTTCAATGCGCGCTCGCCGCAGCCGC
AAGCGCACGGCCTTGCGAAAGAGCCCGCCTGA

Upstream 100 bases:

>100_bases
AAGGGATGGCATCGACCATCCGTACACGATCGCCGGCGACCTTCGGGCGACACCGACGCAACCGAGCGCGACCGGCGTGG
TACCGACCAATGGAGACAGC

Downstream 100 bases:

>100_bases
CGACTAACCGAGATTGCCGCGATTGCGCATCAACAGGTCGCGGAAGCGCTGGGCCGGCGGCGACAGCGACCGGTCCGCGT
GCACCAGCAGCGAGATCTCG

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTPNLQSHGAVPVHPVDEVLPAPRLLALGLQHVLVMYAGAIAVPLIVGGALKLPKDQIAFLIAADLFCCGLVTMIQSIGI
WKVGIRLPVMMGVTFTAIAPIIATGSNPSLGLPAVFGAVMLAGIFTFLVAPYVGKMVRWFPPVVTGTVVLVIGISLMRVG
INWAAGGNPMISTPNGPVPNPNFGVPVNIAIATVVLLTVLALVAFAKGFLCNVAVLIGILTGFAIALSLGKVSFDGLAAA
HWVELITPFHFGWPTFDPMTTVTLCVVMVVIMIEGVGQFLALGEIVGRPVTCDDLTRGLRADGVGALVGAVFNTFTYTSY
AQNVGLVQVTGVRSRWVCATAGAILVVLGCLPKLAFFAASIPQYVLGGAALVMFGMVAATGVRILGHVDFVENKKNAYIV
AVSIALGMIPLVSERFFSQMPELLAKFCQNGILLGTLSAVLLNVLFNARSPQPQAHGLAKEPA

Sequences:

>Translated_463_residues
MTPNLQSHGAVPVHPVDEVLPAPRLLALGLQHVLVMYAGAIAVPLIVGGALKLPKDQIAFLIAADLFCCGLVTMIQSIGI
WKVGIRLPVMMGVTFTAIAPIIATGSNPSLGLPAVFGAVMLAGIFTFLVAPYVGKMVRWFPPVVTGTVVLVIGISLMRVG
INWAAGGNPMISTPNGPVPNPNFGVPVNIAIATVVLLTVLALVAFAKGFLCNVAVLIGILTGFAIALSLGKVSFDGLAAA
HWVELITPFHFGWPTFDPMTTVTLCVVMVVIMIEGVGQFLALGEIVGRPVTCDDLTRGLRADGVGALVGAVFNTFTYTSY
AQNVGLVQVTGVRSRWVCATAGAILVVLGCLPKLAFFAASIPQYVLGGAALVMFGMVAATGVRILGHVDFVENKKNAYIV
AVSIALGMIPLVSERFFSQMPELLAKFCQNGILLGTLSAVLLNVLFNARSPQPQAHGLAKEPA
>Mature_462_residues
TPNLQSHGAVPVHPVDEVLPAPRLLALGLQHVLVMYAGAIAVPLIVGGALKLPKDQIAFLIAADLFCCGLVTMIQSIGIW
KVGIRLPVMMGVTFTAIAPIIATGSNPSLGLPAVFGAVMLAGIFTFLVAPYVGKMVRWFPPVVTGTVVLVIGISLMRVGI
NWAAGGNPMISTPNGPVPNPNFGVPVNIAIATVVLLTVLALVAFAKGFLCNVAVLIGILTGFAIALSLGKVSFDGLAAAH
WVELITPFHFGWPTFDPMTTVTLCVVMVVIMIEGVGQFLALGEIVGRPVTCDDLTRGLRADGVGALVGAVFNTFTYTSYA
QNVGLVQVTGVRSRWVCATAGAILVVLGCLPKLAFFAASIPQYVLGGAALVMFGMVAATGVRILGHVDFVENKKNAYIVA
VSIALGMIPLVSERFFSQMPELLAKFCQNGILLGTLSAVLLNVLFNARSPQPQAHGLAKEPA

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=450, Percent_Identity=25.7777777777778, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI44680143, Length=454, Percent_Identity=26.2114537444934, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI44680148, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40316845, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87082181, Length=452, Percent_Identity=51.3274336283186, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790087, Length=460, Percent_Identity=30.4347826086957, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082178, Length=457, Percent_Identity=28.0087527352298, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788843, Length=402, Percent_Identity=28.6069651741293, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87081818, Length=469, Percent_Identity=26.6524520255864, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17542260, Length=169, Percent_Identity=29.585798816568, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=467, Percent_Identity=23.3404710920771, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=433, Percent_Identity=21.9399538106236, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=169, Percent_Identity=28.4023668639053, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=434, Percent_Identity=22.8110599078341, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=480, Percent_Identity=23.75, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48355; Mature: 48223

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCEEHHHHHHHHHHHHHCCCCCCCHHCCCCCCCC
>Mature Secondary Structure 
TPNLQSHGAVPVHPVDEVLPAPRLLALGLQHVLVMYAGAIAVPLIVGGALKLPKDQIAF
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH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HHHHHHHHHCCEEHHHHHHHHHHHHHCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]