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The map label for this gene is nadC [H]

Identifier: 73542421

GI number: 73542421

Start: 3002289

End: 3003152

Strand: Reverse

Name: nadC [H]

Synonym: Reut_A2736

Alternate gene names: 73542421

Gene position: 3003152-3002289 (Counterclockwise)

Preceding gene: 73542422

Following gene: 73542416

Centisome position: 78.89

GC content: 64.81

Gene sequence:

>864_bases
ATGAGTGTGAATTCGGTGTTCGATAGCTATGGTCCGGCGCTGAAGTCGGCGCTGGAAGCCAACGTCAGCGCGGCGATCGC
CGAGGACGTCGGCAGTGGTGATCTGACCGGCCTGCTGGTGCCGGCGGACAAGCAGGCCCACGCGCGCGTGATCGTGCGTG
AGCAGGCCGTGTTGTGCGGCCAACCGTGGTTCTCGGCCTGCATGAAGGCGGTGGACGAGCGGCTGACGGTCACGTGGAAG
CAGGAAGAGGGTGCCCGCATGGCGCCGGATTCCGTGGTTTGCGAGATCACTGGCCCGGCCCGGGCTCTGCTCACGGCGGA
GCGTCCGGCGCTCAATTTCCTGCAACTGCTGTCGGGCGTGGCAACGGTAACGCGACGCTACGCCGACCTGATCGCCGGCA
CCAATGCGCGCGTGCTTGATACGCGCAAGACGCTGCCGGGCCTGCGGTTGGCCCAGAAGTATGCGGTCCGGATTGGTGGG
GGCGAAAACCAGCGCCTCGCGCTTTACGATGGCATCCTGATCAAGGAAAACCATATCGCCGCGGCGGGCAGCATCACGGC
TGCGATGCAAGCCGCGCTGGCACTCGGTGCCAACGCCTCGATCCAGATCGAAGTGGAATCGCTGGCCGAGCTGGAAGAGG
CGCTGGCCGCTGGCGCGACCTCGATCCTGATCGACAACTTCACCGTGCCGATGATGCATGATGCCGTACGCATCAACGCC
GGCCGTGCACTGCTCGAGGTGTCGGGTGGTGTCAATGCCGACACCATTCGCACATTTGCCGAGACCGGCGTGGATCGTAT
TTCGGTGGGAGCACTGACCAAGGACGTGCGCGCCACCGACTACTCGCTGCGGATCATCGGCTGA

Upstream 100 bases:

>100_bases
TCAATCGCATGCTCGACTTCGCTGCGCAGCAGAAGGCCAATGTCCGGCCGGCGGCTGACCTTGCGAAGGAACAGGCCTTG
TTCCAGGGAATCGGTCCGGC

Downstream 100 bases:

>100_bases
TCGTCAGCTACGTCAGAACAAAAACGGCCCGCTTTATGTGGGCCGTTTTGCTTTCTGCGTGCAGGGACTTCTCTTTAGCG
CTTGCGGGCCGGCTGCATCA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSVNSVFDSYGPALKSALEANVSAAIAEDVGSGDLTGLLVPADKQAHARVIVREQAVLCGQPWFSACMKAVDERLTVTWK
QEEGARMAPDSVVCEITGPARALLTAERPALNFLQLLSGVATVTRRYADLIAGTNARVLDTRKTLPGLRLAQKYAVRIGG
GENQRLALYDGILIKENHIAAAGSITAAMQAALALGANASIQIEVESLAELEEALAAGATSILIDNFTVPMMHDAVRINA
GRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLRIIG

Sequences:

>Translated_287_residues
MSVNSVFDSYGPALKSALEANVSAAIAEDVGSGDLTGLLVPADKQAHARVIVREQAVLCGQPWFSACMKAVDERLTVTWK
QEEGARMAPDSVVCEITGPARALLTAERPALNFLQLLSGVATVTRRYADLIAGTNARVLDTRKTLPGLRLAQKYAVRIGG
GENQRLALYDGILIKENHIAAAGSITAAMQAALALGANASIQIEVESLAELEEALAAGATSILIDNFTVPMMHDAVRINA
GRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLRIIG
>Mature_286_residues
SVNSVFDSYGPALKSALEANVSAAIAEDVGSGDLTGLLVPADKQAHARVIVREQAVLCGQPWFSACMKAVDERLTVTWKQ
EEGARMAPDSVVCEITGPARALLTAERPALNFLQLLSGVATVTRRYADLIAGTNARVLDTRKTLPGLRLAQKYAVRIGGG
ENQRLALYDGILIKENHIAAAGSITAAMQAALALGANASIQIEVESLAELEEALAAGATSILIDNFTVPMMHDAVRINAG
RALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLRIIG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=264, Percent_Identity=34.469696969697, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50, Blast_Score=241, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=35.9861591695502, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30226; Mature: 30095

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNSVFDSYGPALKSALEANVSAAIAEDVGSGDLTGLLVPADKQAHARVIVREQAVLCG
CCCHHHHHHCCHHHHHHHHHCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEHHHHHCC
QPWFSACMKAVDERLTVTWKQEEGARMAPDSVVCEITGPARALLTAERPALNFLQLLSGV
CHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCHHEEEECCCCHHHHHHHHHHH
ATVTRRYADLIAGTNARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGILIKENHIA
HHHHHHHHHHHCCCCCEEEECHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEE
AAGSITAAMQAALALGANASIQIEVESLAELEEALAAGATSILIDNFTVPMMHDAVRINA
CCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCHHHCEEEEEC
GRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLRIIG
CEEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
SVNSVFDSYGPALKSALEANVSAAIAEDVGSGDLTGLLVPADKQAHARVIVREQAVLCG
CCHHHHHHCCHHHHHHHHHCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEHHHHHCC
QPWFSACMKAVDERLTVTWKQEEGARMAPDSVVCEITGPARALLTAERPALNFLQLLSGV
CHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCHHEEEECCCCHHHHHHHHHHH
ATVTRRYADLIAGTNARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGILIKENHIA
HHHHHHHHHHHCCCCCEEEECHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEE
AAGSITAAMQAALALGANASIQIEVESLAELEEALAAGATSILIDNFTVPMMHDAVRINA
CCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCHHHCEEEEEC
GRALLEVSGGVNADTIRTFAETGVDRISVGALTKDVRATDYSLRIIG
CEEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]