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The map label for this gene is hisC1

Identifier: 73542259

GI number: 73542259

Start: 2818864

End: 2819994

Strand: Reverse

Name: hisC1

Synonym: Reut_A2574

Alternate gene names: 73542259

Gene position: 2819994-2818864 (Counterclockwise)

Preceding gene: 73542260

Following gene: 73542258

Centisome position: 74.08

GC content: 65.52

Gene sequence:

>1131_bases
ATGGCAGAGCAAGGCAAGCAAGGCGGCAAGGTACCGTTCGGCCCGGATTACGTCAGGGCGATTTCGCCTTACATCGCGGG
CAAGCCGATTTCAGAGGTGGCGCGCGAGTTCGGCCTCGACGAGGCCGGCATCGTGAAGCTCGCGTCGAACGAGAACCCGC
TGGGCATGCCGGAGTCTGCGAAACACGCGGCGGCCGCGGCCATTGCCGAACTGGGTCGTTACCCCGATTCGAACGGCTTC
GAACTGAAAGCTGCGCTTTCGACAAAGCTCGGTGTGCCGCAGGACTGGCTTACGCTCGGCAACGGCAGCAACGACATCCT
CGAACTGGCCGCGCATGCGCTGGTCACGCCGGGGCAGTCGATCGTGTACGCCGAGTATTCGTTCGCGGTCTACGCGCTCG
CGACGCAGGAGATCGGCGCGCGCGCAATCGTGGTGAAGGCGCGTGATTATGGCCATGATCTCGACGCCATGGCGGCGGCG
ATCACGTCCGACACGCGTCTGGTGTTCATCGCCAACCCGAACAACCCGACCGGCACGTTCGTGCCCGCGGCGGCGCTGGA
AACGTTCCTGGCCAAGGTGCCGGCCGAGGTAGTCGTGGTACTGGACGAGGCGTACAACGAATATCTCGATGACGACCAGC
AATATGATTCGGTGGCATGGGTTCGCCGCTATCCGAACCTGCTGGTGTCGCGCACGTTCTCGAAGGCCTACGGGCTGGCG
GGCCTGCGCATCGGCTATGCCGTGGCGCAGCCGGAACTGACCGATCTGCTGAACCGCATCCGGCAGCCGTTCAATGTCAA
CAGCGTCGCCCAGGCGGCGGCCGTGGCTGCGCTTGGCGACACGGCATTCCTGCAGCGCAGCGCCGAACTCAACCGGGCGG
GCAAGGCCCAGCTCGTTGAGGCGTTTTCGCGCCTCGGGCTCGAGTTTGTCGCATCGTCCGGCAACTTCGTGCTGGTGCGC
GTCGGCGATGACGATGACGCCGGTGCGCGCGTCAACGTGGCGCTGCTGAGGCAGGGCGTGATCGTGCGGCCCGTGGGCAA
CTACGGCATGCCGCGCTGGCTGCGTGTCACGATCGGCTTGCCCGACGAAAACGCCGCCTTCATCGCGGCGCTGGAGCGCG
CGCTGAAGTAA

Upstream 100 bases:

>100_bases
CGCGATCGAGACGCTGCGGCGCAACGCAGCGTACCTGAAGGTGCTCGGGTCGTACCCGTCGAGCAAGTAAGCACGCGCAG
ATACGAGGCAAGGAGACAAG

Downstream 100 bases:

>100_bases
CCGCGCGCAACGGCCATGCATTTCCTTTTTCGAATTTCCCGTATTGCCCGCCCCCGAGGGCTGAGATTGTGAGCGCTCTG
CATTTTTCCCGTGTTGTGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MAEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESAKHAAAAAIAELGRYPDSNGF
ELKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQSIVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAA
ITSDTRLVFIANPNNPTGTFVPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLA
GLRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVEAFSRLGLEFVASSGNFVLVR
VGDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGLPDENAAFIAALERALK

Sequences:

>Translated_376_residues
MAEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESAKHAAAAAIAELGRYPDSNGF
ELKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQSIVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAA
ITSDTRLVFIANPNNPTGTFVPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLA
GLRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVEAFSRLGLEFVASSGNFVLVR
VGDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGLPDENAAFIAALERALK
>Mature_375_residues
AEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESAKHAAAAAIAELGRYPDSNGFE
LKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQSIVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAAI
TSDTRLVFIANPNNPTGTFVPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLAG
LRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVEAFSRLGLEFVASSGNFVLVRV
GDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGLPDENAAFIAALERALK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=362, Percent_Identity=27.6243093922652, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788627, Length=159, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786816, Length=233, Percent_Identity=26.1802575107296, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=389, Percent_Identity=27.7634961439589, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_CUPPJ (Q46Y48)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296779.1
- ProteinModelPortal:   Q46Y48
- SMR:   Q46Y48
- GeneID:   3609598
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2574
- NMPDR:   fig|264198.3.peg.3328
- HOGENOM:   HBG646350
- OMA:   QWLRISI
- ProtClustDB:   PRK02731
- BioCyc:   REUT264198:REUT_A2574-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40148; Mature: 40017

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCH
KHAAAAAIAELGRYPDSNGFELKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQS
HHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCHHHHEECCCCHHHHHHHHHHHCCCCCE
IVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAAITSDTRLVFIANPNNPTGTF
EEEEEECEEEEEEEHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCE
VPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLA
EHHHHHHHHHHHCCHHEEEEEHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
GLRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVE
HHEEHHEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHH
AFSRLGLEFVASSGNFVLVRVGDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGL
HHHHCCEEEEECCCCEEEEEECCCCCCCCEEEHHHHHCCEEEEECCCCCCCEEEEEEEEC
PDENAAFIAALERALK
CCCCHHHHHHHHHHHC
>Mature Secondary Structure 
AEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCH
KHAAAAAIAELGRYPDSNGFELKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQS
HHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCHHHHEECCCCHHHHHHHHHHHCCCCCE
IVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAAITSDTRLVFIANPNNPTGTF
EEEEEECEEEEEEEHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCE
VPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLA
EHHHHHHHHHHHCCHHEEEEEHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
GLRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVE
HHEEHHEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHH
AFSRLGLEFVASSGNFVLVRVGDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGL
HHHHCCEEEEECCCCEEEEEECCCCCCCCEEEHHHHHCCEEEEECCCCCCCEEEEEEEEC
PDENAAFIAALERALK
CCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA