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The map label for this gene is prlC [H]

Identifier: 73540992

GI number: 73540992

Start: 1387353

End: 1389431

Strand: Reverse

Name: prlC [H]

Synonym: Reut_A1298

Alternate gene names: 73540992

Gene position: 1389431-1387353 (Counterclockwise)

Preceding gene: 73540993

Following gene: 73540991

Centisome position: 36.5

GC content: 65.46

Gene sequence:

>2079_bases
ATGGACCAAGCCGTCAACAATCCACTGCTGGACTTCACCGACCTGCCGCGCTTCTCCGAGATCCGCCCCGAGCACATCAG
CCCGGCGCTCGACGTGCTGCTCGAGCGTGCCCAGGCTGCCGTGGCCCGCGCCGAAGACCCCGCCACGCCGGCCGACTGGG
GGAATGCCGTCGAGGCACTGGAAACCGCCACCGAGCCGCTGGGGCGCGCGTGGGGCGTGGTCGGCCATCTGAGCGCGGTC
GCCGACACGCCGGAACTGCGCAAGGCGCACGCCGAAAACCTGCCGCGCATGACCGAGTTCTGGTCGTCGCTCGGACAGAG
CCTGGCGCTCTATGAAAAGTACAAGGCGCTCGCAGCCAGCCCCGAGTTCGCCGGCATGGACGCCGCGCGCCACCAGCTGA
TCGAGAACGAGCTGCGCGGCTTCCGCCTGGGCGGCGCCGAACTGCCCGAAGACAAGAAGCCACGCTTTGCCGAGATCCAG
GAACACCAGGCGCAGCTGTCCAAGGCGTTTTCCGACCACGTGCTCGATGCCACCAATGCGTACGCGCTGATCATCGAAGA
CCCCGCGCGTCTGTCCGGCTTGCCCGAAGACGCGAAGGAAGCCGCGCGCCACGCCGCCGAGAAGGACGGCAAGGCCGGCT
GGAAGTTCACACTGCACTTCCCGTCCTATTTCCCCGTGCTCCAATACGCGGACGACCGCGCGCTGCGCCAGACCCTGTAC
GAAGCCAACGTGACACGTGCGTCGGCGCAGGCCCCGCAGTACGGCAACGGCCAGGCCGATTGGGACAACACGGACAATAT
GCGCGAGCAGCTCGCGCTGCGCCGCGAAGAAGCGCAGATGCTCGGCTACCAGTGCTACGGCGAAGTCTCGCTGGTGCCGA
AGATGGCCGAATCGCCGGCCGAGGTGCTCAAGTTCCTCGATGAACTCGCCGTCAAGGCGCGTCCGTATGCCGAGAAGGAC
TGGGCCGAACTCAGGGCCTTCGCTGCGGCGGAACTGGGACTGGCCGAACTCGCACCGTGGGACGTCGCCTACGCCTCCGA
AAAGCTGCGCGAGCAGCGCTATGCGTTCTCCGAACACGAGGTGAAGCAGTACTTCCCCGAGCACAAGGTGCTGCAGGGCC
TGTTCGGTGCTGTGGAGCGGCTGTTCTCGGTCAAGATCCAGCCCGACCAGTCGCAGACCTGGCACAAGGATGTGCGCTTC
TTCCGCGTGAGCGCGACCGATGGCACGCTGCTCGCCCAGTTCTATATCGACCTCTATGCGCGCGAGGGCAAGCGCGGCGG
TGCGTGGATGGATGATGCGCGTGGGCGCAAGATCCTCGCAGACGGCGAGGTGCAAACACCCGTGGCCTACCTGACCTGCA
ACTTCTCGTCGCCGGTCGGCGACAAGCCCGCGCTGTTCACGCACGACGAAGTCATCACGCTGTTCCATGAGTTCGGCCAT
GGCCTGCACCATATGCTGACGCAGGTTGGCGAGTTGGGCGTGTCTGGCATCAACGGCGTGGAATGGGATGCAGTCGAGCT
GCCGTCCCAGTTCATGGAGAACTTCTGCTGGGAATTCGAAGTGCTCAGCGGCATGACGCAGCATGTCGACAGCGGCGAGC
CGCTGCCGCGCGCGCTGTTTGACCGCATGCTCGCCGCCAAGAATTTCCAGAACGGCATGATGACGCTTCGCCAGATCGTG
TTCTCGTCCTTCGACATGCACCTGCACACCGACTTCGATCCGCAAGGTGCCAAGTCGGTGCTCGACCTGTCGCGCGAGAT
CAACGACCGCGTGCATGTGGTGCCACAGTACCCGCTGTCGCGCTGGCCCAATACCTTCAGCCACATCTTCGCTGGCGGCT
ATGCCGCGGGCTACTACAGCTACAAGTGGGCTGAAGTGCTGTCGGCCGACGTGTATGCCGCGTTCGAAGAAGCCGCGCAA
CTTTCGGGCACCGTGCTCGACAGTGAAACCGGCGCTCGCTACCAGCGCGAGATCCTGTCGGTCGGCGGCAGCCGCCCGGC
CATGGATTCGTTCGTCGCGTTCCGCGGCCGCGCGCCGCAGATCGACGCGCTGCTGCGCCACGGAGGCATGGCAGCATGA

Upstream 100 bases:

>100_bases
CGCGCCGTTGCGGCACGTGCCGCAACGGCACTGGAAAAGCACCGGGGCTGCCCCAATCTGCAAGCCATTGCCTCTTCAGG
CCTGATAACCGAGAACCGCC

Downstream 100 bases:

>100_bases
GCGCGGTGCTGCCTACGTCGGGGCCGCTTCGCATTGCGAGCTGGAACGTCAACTCCCTCAAGGTCCGCCTGCCGCAGGTG
CTGCAATGGCTGACGGAACA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MDQAVNNPLLDFTDLPRFSEIRPEHISPALDVLLERAQAAVARAEDPATPADWGNAVEALETATEPLGRAWGVVGHLSAV
ADTPELRKAHAENLPRMTEFWSSLGQSLALYEKYKALAASPEFAGMDAARHQLIENELRGFRLGGAELPEDKKPRFAEIQ
EHQAQLSKAFSDHVLDATNAYALIIEDPARLSGLPEDAKEAARHAAEKDGKAGWKFTLHFPSYFPVLQYADDRALRQTLY
EANVTRASAQAPQYGNGQADWDNTDNMREQLALRREEAQMLGYQCYGEVSLVPKMAESPAEVLKFLDELAVKARPYAEKD
WAELRAFAAAELGLAELAPWDVAYASEKLREQRYAFSEHEVKQYFPEHKVLQGLFGAVERLFSVKIQPDQSQTWHKDVRF
FRVSATDGTLLAQFYIDLYAREGKRGGAWMDDARGRKILADGEVQTPVAYLTCNFSSPVGDKPALFTHDEVITLFHEFGH
GLHHMLTQVGELGVSGINGVEWDAVELPSQFMENFCWEFEVLSGMTQHVDSGEPLPRALFDRMLAAKNFQNGMMTLRQIV
FSSFDMHLHTDFDPQGAKSVLDLSREINDRVHVVPQYPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQ
LSGTVLDSETGARYQREILSVGGSRPAMDSFVAFRGRAPQIDALLRHGGMAA

Sequences:

>Translated_692_residues
MDQAVNNPLLDFTDLPRFSEIRPEHISPALDVLLERAQAAVARAEDPATPADWGNAVEALETATEPLGRAWGVVGHLSAV
ADTPELRKAHAENLPRMTEFWSSLGQSLALYEKYKALAASPEFAGMDAARHQLIENELRGFRLGGAELPEDKKPRFAEIQ
EHQAQLSKAFSDHVLDATNAYALIIEDPARLSGLPEDAKEAARHAAEKDGKAGWKFTLHFPSYFPVLQYADDRALRQTLY
EANVTRASAQAPQYGNGQADWDNTDNMREQLALRREEAQMLGYQCYGEVSLVPKMAESPAEVLKFLDELAVKARPYAEKD
WAELRAFAAAELGLAELAPWDVAYASEKLREQRYAFSEHEVKQYFPEHKVLQGLFGAVERLFSVKIQPDQSQTWHKDVRF
FRVSATDGTLLAQFYIDLYAREGKRGGAWMDDARGRKILADGEVQTPVAYLTCNFSSPVGDKPALFTHDEVITLFHEFGH
GLHHMLTQVGELGVSGINGVEWDAVELPSQFMENFCWEFEVLSGMTQHVDSGEPLPRALFDRMLAAKNFQNGMMTLRQIV
FSSFDMHLHTDFDPQGAKSVLDLSREINDRVHVVPQYPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQ
LSGTVLDSETGARYQREILSVGGSRPAMDSFVAFRGRAPQIDALLRHGGMAA
>Mature_692_residues
MDQAVNNPLLDFTDLPRFSEIRPEHISPALDVLLERAQAAVARAEDPATPADWGNAVEALETATEPLGRAWGVVGHLSAV
ADTPELRKAHAENLPRMTEFWSSLGQSLALYEKYKALAASPEFAGMDAARHQLIENELRGFRLGGAELPEDKKPRFAEIQ
EHQAQLSKAFSDHVLDATNAYALIIEDPARLSGLPEDAKEAARHAAEKDGKAGWKFTLHFPSYFPVLQYADDRALRQTLY
EANVTRASAQAPQYGNGQADWDNTDNMREQLALRREEAQMLGYQCYGEVSLVPKMAESPAEVLKFLDELAVKARPYAEKD
WAELRAFAAAELGLAELAPWDVAYASEKLREQRYAFSEHEVKQYFPEHKVLQGLFGAVERLFSVKIQPDQSQTWHKDVRF
FRVSATDGTLLAQFYIDLYAREGKRGGAWMDDARGRKILADGEVQTPVAYLTCNFSSPVGDKPALFTHDEVITLFHEFGH
GLHHMLTQVGELGVSGINGVEWDAVELPSQFMENFCWEFEVLSGMTQHVDSGEPLPRALFDRMLAAKNFQNGMMTLRQIV
FSSFDMHLHTDFDPQGAKSVLDLSREINDRVHVVPQYPLSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQ
LSGTVLDSETGARYQREILSVGGSRPAMDSFVAFRGRAPQIDALLRHGGMAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=620, Percent_Identity=31.4516129032258, Blast_Score=292, Evalue=7e-79,
Organism=Homo sapiens, GI14149738, Length=622, Percent_Identity=30.064308681672, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI156105687, Length=674, Percent_Identity=23.7388724035608, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1789913, Length=687, Percent_Identity=48.6171761280932, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=694, Percent_Identity=30.6916426512968, Blast_Score=269, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71999758, Length=497, Percent_Identity=24.9496981891348, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32565901, Length=632, Percent_Identity=21.6772151898734, Blast_Score=84, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=690, Percent_Identity=26.6666666666667, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=685, Percent_Identity=22.4817518248175, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21356111, Length=691, Percent_Identity=28.2199710564399, Blast_Score=242, Evalue=7e-64,
Organism=Drosophila melanogaster, GI20129717, Length=407, Percent_Identity=28.5012285012285, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77239; Mature: 77239

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQAVNNPLLDFTDLPRFSEIRPEHISPALDVLLERAQAAVARAEDPATPADWGNAVEAL
CCCCCCCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ETATEPLGRAWGVVGHLSAVADTPELRKAHAENLPRMTEFWSSLGQSLALYEKYKALAAS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PEFAGMDAARHQLIENELRGFRLGGAELPEDKKPRFAEIQEHQAQLSKAFSDHVLDATNA
CCCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YALIIEDPARLSGLPEDAKEAARHAAEKDGKAGWKFTLHFPSYFPVLQYADDRALRQTLY
EEEEEECCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCHHHHHHHHH
EANVTRASAQAPQYGNGQADWDNTDNMREQLALRREEAQMLGYQCYGEVSLVPKMAESPA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCHH
EVLKFLDELAVKARPYAEKDWAELRAFAAAELGLAELAPWDVAYASEKLREQRYAFSEHE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHH
VKQYFPEHKVLQGLFGAVERLFSVKIQPDQSQTWHKDVRFFRVSATDGTLLAQFYIDLYA
HHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHH
REGKRGGAWMDDARGRKILADGEVQTPVAYLTCNFSSPVGDKPALFTHDEVITLFHEFGH
HCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHCH
GLHHMLTQVGELGVSGINGVEWDAVELPSQFMENFCWEFEVLSGMTQHVDSGEPLPRALF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DRMLAAKNFQNGMMTLRQIVFSSFDMHLHTDFDPQGAKSVLDLSREINDRVHVVPQYPLS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQLSGTVLDSETGARYQREILS
HCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
VGGSRPAMDSFVAFRGRAPQIDALLRHGGMAA
CCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MDQAVNNPLLDFTDLPRFSEIRPEHISPALDVLLERAQAAVARAEDPATPADWGNAVEAL
CCCCCCCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ETATEPLGRAWGVVGHLSAVADTPELRKAHAENLPRMTEFWSSLGQSLALYEKYKALAAS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PEFAGMDAARHQLIENELRGFRLGGAELPEDKKPRFAEIQEHQAQLSKAFSDHVLDATNA
CCCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YALIIEDPARLSGLPEDAKEAARHAAEKDGKAGWKFTLHFPSYFPVLQYADDRALRQTLY
EEEEEECCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCHHHHHHHHH
EANVTRASAQAPQYGNGQADWDNTDNMREQLALRREEAQMLGYQCYGEVSLVPKMAESPA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCHH
EVLKFLDELAVKARPYAEKDWAELRAFAAAELGLAELAPWDVAYASEKLREQRYAFSEHE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHH
VKQYFPEHKVLQGLFGAVERLFSVKIQPDQSQTWHKDVRFFRVSATDGTLLAQFYIDLYA
HHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHH
REGKRGGAWMDDARGRKILADGEVQTPVAYLTCNFSSPVGDKPALFTHDEVITLFHEFGH
HCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHCH
GLHHMLTQVGELGVSGINGVEWDAVELPSQFMENFCWEFEVLSGMTQHVDSGEPLPRALF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DRMLAAKNFQNGMMTLRQIVFSSFDMHLHTDFDPQGAKSVLDLSREINDRVHVVPQYPLS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADVYAAFEEAAQLSGTVLDSETGARYQREILS
HCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
VGGSRPAMDSFVAFRGRAPQIDALLRHGGMAA
CCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]