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The map label for this gene is cyp18 [H]

Identifier: 73540821

GI number: 73540821

Start: 1211899

End: 1212399

Strand: Reverse

Name: cyp18 [H]

Synonym: Reut_A1119

Alternate gene names: 73540821

Gene position: 1212399-1211899 (Counterclockwise)

Preceding gene: 73540822

Following gene: 73540820

Centisome position: 31.85

GC content: 59.68

Gene sequence:

>501_bases
ATGTCCAAGGTCCAGCTCCAAACCAACCAGGGTGTCATCACCATCGAACTCGACGCCGAGAAGGCTCCGAAGTCGGTCGA
GAACTTCCTGTCGTATGTCCGCAAAGGCCACTATGACAACACCATCTTCCACCGCGTGATCAAGAACTTCATGATCCAGG
GCGGCGGCTTCGAGCCGGGCATGAAGCAAAAGGGCACCGATGCCCCGATCGAAAACGAGGCCGGCAACGGCCTGAAGAAC
GACAAGTACACCGTGGCCATGGCGCGCACCAACGCACCGCATTCCGCCACGGCCCAGTTCTTCATCAACGTGGTCGACAA
CGACTTCCTGAACTTCAGCTCGCCGACGCCGCAAGGTTTCGGCTACGCCGTGTTCGGCAAGGTCGTTGAAGGCACCGACG
TGGTCGACCAGATCAAGGGCGTGCGCACCGGCAGCTCGGGCTTCCATCAGGACGTGCCGCTGGAAGACGTCGTGATCGAA
AAGGCTGTGGTCGTCGAGTAA

Upstream 100 bases:

>100_bases
GACCACGGCCTACGGCCCCATGCGCAATGTGCCGGCTGCGCCCATTGTGATCGAGTCGGCCAGCGTCATTCAATAAACAC
CACCGTACAGAGGAAAGCCC

Downstream 100 bases:

>100_bases
GAACGCGATCCATGCTTCACGATTGCGGCTTCATGCACGCTTCCCTGCCGACAACTACATCGACCTGGCCGCGCGCATGA
CCGCAATCCCCACCACGCCG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSKVQLQTNQGVITIELDAEKAPKSVENFLSYVRKGHYDNTIFHRVIKNFMIQGGGFEPGMKQKGTDAPIENEAGNGLKN
DKYTVAMARTNAPHSATAQFFINVVDNDFLNFSSPTPQGFGYAVFGKVVEGTDVVDQIKGVRTGSSGFHQDVPLEDVVIE
KAVVVE

Sequences:

>Translated_166_residues
MSKVQLQTNQGVITIELDAEKAPKSVENFLSYVRKGHYDNTIFHRVIKNFMIQGGGFEPGMKQKGTDAPIENEAGNGLKN
DKYTVAMARTNAPHSATAQFFINVVDNDFLNFSSPTPQGFGYAVFGKVVEGTDVVDQIKGVRTGSSGFHQDVPLEDVVIE
KAVVVE
>Mature_165_residues
SKVQLQTNQGVITIELDAEKAPKSVENFLSYVRKGHYDNTIFHRVIKNFMIQGGGFEPGMKQKGTDAPIENEAGNGLKND
KYTVAMARTNAPHSATAQFFINVVDNDFLNFSSPTPQGFGYAVFGKVVEGTDVVDQIKGVRTGSSGFHQDVPLEDVVIEK
AVVVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=35.5828220858896, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=31.5151515151515, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=34.5911949685535, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=30.6748466257669, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=30.6748466257669, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=30.6748466257669, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI64276486, Length=132, Percent_Identity=37.1212121212121, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4758950, Length=162, Percent_Identity=34.5679012345679, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=68.7116564417178, Blast_Score=230, Evalue=4e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=56.1728395061728, Blast_Score=168, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=35.6643356643357, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=35.6643356643357, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=34.5454545454545, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=37.0629370629371, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=34.8101265822785, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=28.7425149700599, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=154, Percent_Identity=33.7662337662338, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=156, Percent_Identity=34.6153846153846, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=33.1325301204819, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=28.4848484848485, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=35.1851851851852, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652460, Length=164, Percent_Identity=28.6585365853659, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20130249, Length=154, Percent_Identity=33.7662337662338, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18139; Mature: 18007

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVQLQTNQGVITIELDAEKAPKSVENFLSYVRKGHYDNTIFHRVIKNFMIQGGGFEPG
CCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
MKQKGTDAPIENEAGNGLKNDKYTVAMARTNAPHSATAQFFINVVDNDFLNFSSPTPQGF
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHEEEHHCCCCCCCCCCCCCCC
GYAVFGKVVEGTDVVDQIKGVRTGSSGFHQDVPLEDVVIEKAVVVE
CHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECC
>Mature Secondary Structure 
SKVQLQTNQGVITIELDAEKAPKSVENFLSYVRKGHYDNTIFHRVIKNFMIQGGGFEPG
CCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
MKQKGTDAPIENEAGNGLKNDKYTVAMARTNAPHSATAQFFINVVDNDFLNFSSPTPQGF
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHEEEHHCCCCCCCCCCCCCCC
GYAVFGKVVEGTDVVDQIKGVRTGSSGFHQDVPLEDVVIEKAVVVE
CHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]