BacMap

Definition	Streptococcus pyogenes MGAS5005 chromosome, complete genome.
Accession	NC_007297
Length	1,838,554

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The map label for this gene is butA [H]

Identifier: 71910347

GI number: 71910347

Start: 521927

End: 522541

Strand: Direct

Name: butA [H]

Synonym: M5005_Spy_0534

Alternate gene names: 71910347

Gene position: 521927-522541 (Clockwise)

Preceding gene: 71910345

Following gene: 71910348

Centisome position: 28.39

GC content: 40.0

Gene sequence:

>615_bases
ATGTCAAAAGTTGCTATTGTTACTGGTGCTGGTCAAGGAATTGGATTTGCTATTGCGAAACGTCTTCATGCAGACGGCTT
TAAAATAGGCATTTTAGACTATAATGAAGAGACTGCTCAGGCTGCGGTTGATAAACTATCACCTGAGGATGCTGTTGCAG
TTGTAGCAGATGTTTCAAAACGTGACCAAGTTTTTGATGCTTTCCAAAAAGTTGTAGATACTTTTGGTGATTTGAATGTT
GTTGTTAACAATGCAGGCGTTGCCCCAACAACCCCTCTTGACACGATTACTGAAGAGCAGTTTGAAAAGGCTTTTGCAAT
CAATGTCGGAGGAACGATTTGGGGAAGCCAAGCAGCTCAAAAACATTTTAGAGAATTAGGTCATGGCGGAAAAATTATAA
ATGCAACATCACAAGCAGGATGTGAAGGAAATCCTAATTTGACTGTTTATGGTGGTACAAAATTTGCAGTTCGTGGTATT
ACACAGACTTTGGCAAAGGATTTGGCATCAGAAGGAATCACAGTCAATGCTTACGCACCAGGTATTGTTAAGACACCTAT
GATGTTTGCTATTGCCCATGAAGTTGGTAAAAATGCAGGCAAAGATGATGAATGA

Upstream 100 bases:

>100_bases
AAGTAATCAATAAGCCAAGCCTAAAGCTGAACTTAGTTTAAGAACACTGACTTTTTGAGAGCAACCTAATCGGTTGACTA
AAAAATATGAGGTGGAAGAT

Downstream 100 bases:

>100_bases
GGTATGGAGCAATTTGCAAAAGATATCACTTTGAAACGCTTGTCTGAACCAGAAGATATTGCTAATGCAGTAGGCTTCTT
AGCGGGAGATGATTCAAATT

Product: acetoin reductase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNV
VVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGI
TQTLAKDLASEGITVNAYAPGIVKTPMMFAIAHEVGKNAGKDDE

Sequences:

>Translated_204_residues
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNV
VVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGI
TQTLAKDLASEGITVNAYAPGIVKTPMMFAIAHEVGKNAGKDDE
>Mature_203_residues
SKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVVDTFGDLNVV
VNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGIT
QTLAKDLASEGITVNAYAPGIVKTPMMFAIAHEVGKNAGKDDE

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=37, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI15277342, Length=204, Percent_Identity=34.3137254901961, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=36.1581920903955, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI40254992, Length=187, Percent_Identity=32.620320855615, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI32483357, Length=188, Percent_Identity=33.5106382978723, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI7705925, Length=182, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI210032110, Length=195, Percent_Identity=33.8461538461538, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4758504, Length=203, Percent_Identity=31.5270935960591, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI142976729, Length=190, Percent_Identity=33.1578947368421, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI19923817, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI5031737, Length=187, Percent_Identity=32.620320855615, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=32.7956989247312, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI59889578, Length=170, Percent_Identity=31.1764705882353, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=31.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4504503, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI83715985, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=186, Percent_Identity=29.5698924731183, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI109715829, Length=199, Percent_Identity=27.6381909547739, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=25.9067357512953, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI25282469, Length=215, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790717, Length=191, Percent_Identity=34.0314136125654, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788459, Length=192, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=32.2916666666667, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=183, Percent_Identity=32.2404371584699, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=33.8461538461538, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789057, Length=193, Percent_Identity=27.4611398963731, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=208, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786812, Length=183, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789378, Length=194, Percent_Identity=32.9896907216495, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787905, Length=185, Percent_Identity=31.3513513513514, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI2367365, Length=186, Percent_Identity=29.5698924731183, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=29.2817679558011, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=28.4974093264249, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=195, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=190, Percent_Identity=34.2105263157895, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17531453, Length=193, Percent_Identity=34.7150259067358, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=187, Percent_Identity=33.6898395721925, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17567345, Length=192, Percent_Identity=31.25, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=34.1968911917098, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=191, Percent_Identity=32.9842931937173, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=186, Percent_Identity=32.258064516129, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=34.1968911917098, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=29.5566502463054, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=193, Percent_Identity=31.6062176165803, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=193, Percent_Identity=31.6062176165803, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=198, Percent_Identity=32.8282828282828, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=193, Percent_Identity=32.1243523316062, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=31.0160427807487, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=32.6424870466321, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=194, Percent_Identity=30.4123711340206, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=198, Percent_Identity=31.3131313131313, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=196, Percent_Identity=31.6326530612245, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=197, Percent_Identity=30.9644670050761, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=199, Percent_Identity=26.1306532663317, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=196, Percent_Identity=34.1836734693878, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=196, Percent_Identity=31.1224489795918, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=201, Percent_Identity=30.3482587064677, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=216, Percent_Identity=26.8518518518519, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=197, Percent_Identity=27.9187817258883, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=188, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=30.3664921465969, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=212, Percent_Identity=30.188679245283, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640492, Length=168, Percent_Identity=36.9047619047619, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281364892, Length=170, Percent_Identity=33.5294117647059, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=32.8125, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639444, Length=195, Percent_Identity=32.3076923076923, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=203, Percent_Identity=32.512315270936, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737361, Length=204, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281364494, Length=196, Percent_Identity=31.1224489795918, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=188, Percent_Identity=28.1914893617021, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=205, Percent_Identity=29.7560975609756, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643142, Length=185, Percent_Identity=32.4324324324324, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24581726, Length=173, Percent_Identity=26.5895953757225, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221331218, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665243, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357041, Length=206, Percent_Identity=29.126213592233, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007236, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=28.042328042328, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=28.042328042328, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221331216, Length=192, Percent_Identity=28.125, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24665247, Length=192, Percent_Identity=28.125, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584744, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574402, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28571387, Length=198, Percent_Identity=26.2626262626263, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641232, Length=196, Percent_Identity=28.0612244897959, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644337, Length=186, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641388, Length=203, Percent_Identity=30.0492610837438, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649181, Length=189, Percent_Identity=29.1005291005291, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221510726, Length=193, Percent_Identity=29.0155440414508, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 21350; Mature: 21219

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSK
CCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCHHEEEEHHCHH
RDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQ
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHH
KHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGITQTLAKDLASEGITVNAYAP
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECC
GIVKTPMMFAIAHEVGKNAGKDDE
CHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSK
CCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCHHEEEEHHCHH
RDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQ
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHH
KHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGITQTLAKDLASEGITVNAYAP
HHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECC
GIVKTPMMFAIAHEVGKNAGKDDE
CHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA