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The map label for this gene is fbaA [H]

Identifier: 71892036

GI number: 71892036

Start: 298347

End: 299429

Strand: Direct

Name: fbaA [H]

Synonym: BPEN_262

Alternate gene names: 71892036

Gene position: 298347-299429 (Clockwise)

Preceding gene: 71892035

Following gene: 71892037

Centisome position: 37.69

GC content: 30.38

Gene sequence:

>1083_bases
ATGACTAAGATCCTCGATTTTACAAAACCAGGTGTAGTTACTGGAAACAATGTACAGAAAATATTTGATTTTGCAAAAAA
AAACAATTTTGCTTTACCAGCGGTAAACTGTATAGGAATGGATTCAATTAATGCTGCATTAGAATCTGCAGCTAATATGC
AGTCTCCTATTATTTTACAGTTTTCTAAAAAAGGATCTGCTTTCATGGCAGGATATGGTTTAAATAGTGATAAAAATGAT
CATAATACAGCAGTATTAGGAGCTGTCTCTGGTAGTCTACATGTACATCATATTTCTAAACATTATGGTATTCCTGTTAT
TTTGCATACTGATCATTGTACTAAAAAAAATTTGCCTTGGATTAATACTCTATTGGATTTAGGTGCAAAGCATTTTTATG
AAACTGGTAGTCCATTATTTTCGTCTCATATGATTGATTTATCTGAAGAATCTTTAAAAGAAAATATAGAAATTAGCTCA
CAGTATTTAAGTCGTATGCACAAATTAAATATGACTTTAGAAATAGAATTAGGTTGCACCGGAGGAGAAGAAGATGGCAT
AGATCACCATCATTTGGATCGTTCACTTTTATATACAAACCCAGAAGATATAACTTATGCTTATGAAAAATTACATATTA
TCAGTCCTCGATTTATTATAGCTGCATCATTTGGCAATGTACATGGTGTATACAAACCAGGCAACATACGATTGGATCCA
AAAATTCTTCAAAAATCACAAAAATACGTTTCGAATAAATTTGGATTACCTGACAATTTTTTAAATTTAGTATTTCACGG
AGGATCTGGATCTACAGAAGAAGAAATTAAAGAAGCTATCAGTTACGGTGTTGTAAAAATGAATATTGATACTGATATAC
AGTGGGCTACTTGGGAAGGTATTTTAAAATACTACCAACATAATAAAAGCTTTCTTCAAACTCAATTAGGTAATCCATAT
GGAAATGATCAACCAAATAAAAAATTTTATGATCCACGTATTTGGATTCGTGCAGGACAAAAATCAATGGTTAAGTATTT
AGAAAAAATATTTTACACCTTAAATGCTGTTAATATTTTGTAA

Upstream 100 bases:

>100_bases
AAATAACATGAATTAACCAGTATTATATATGAAAAATATATACGACTATATTTAAATAGTCTTGTCGATGTATTCTTTCA
TTAACAACAGAAGAAAATAA

Downstream 100 bases:

>100_bases
AATAATTTTTTAATAACAAATTATAATATACTAGATTAGATTCGTGTATCGAATAAAATTCAAATTATATGAAGTTAAAT
TTGATGAATATTATTAATAT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTKILDFTKPGVVTGNNVQKIFDFAKKNNFALPAVNCIGMDSINAALESAANMQSPIILQFSKKGSAFMAGYGLNSDKND
HNTAVLGAVSGSLHVHHISKHYGIPVILHTDHCTKKNLPWINTLLDLGAKHFYETGSPLFSSHMIDLSEESLKENIEISS
QYLSRMHKLNMTLEIELGCTGGEEDGIDHHHLDRSLLYTNPEDITYAYEKLHIISPRFIIAASFGNVHGVYKPGNIRLDP
KILQKSQKYVSNKFGLPDNFLNLVFHGGSGSTEEEIKEAISYGVVKMNIDTDIQWATWEGILKYYQHNKSFLQTQLGNPY
GNDQPNKKFYDPRIWIRAGQKSMVKYLEKIFYTLNAVNIL

Sequences:

>Translated_360_residues
MTKILDFTKPGVVTGNNVQKIFDFAKKNNFALPAVNCIGMDSINAALESAANMQSPIILQFSKKGSAFMAGYGLNSDKND
HNTAVLGAVSGSLHVHHISKHYGIPVILHTDHCTKKNLPWINTLLDLGAKHFYETGSPLFSSHMIDLSEESLKENIEISS
QYLSRMHKLNMTLEIELGCTGGEEDGIDHHHLDRSLLYTNPEDITYAYEKLHIISPRFIIAASFGNVHGVYKPGNIRLDP
KILQKSQKYVSNKFGLPDNFLNLVFHGGSGSTEEEIKEAISYGVVKMNIDTDIQWATWEGILKYYQHNKSFLQTQLGNPY
GNDQPNKKFYDPRIWIRAGQKSMVKYLEKIFYTLNAVNIL
>Mature_359_residues
TKILDFTKPGVVTGNNVQKIFDFAKKNNFALPAVNCIGMDSINAALESAANMQSPIILQFSKKGSAFMAGYGLNSDKNDH
NTAVLGAVSGSLHVHHISKHYGIPVILHTDHCTKKNLPWINTLLDLGAKHFYETGSPLFSSHMIDLSEESLKENIEISSQ
YLSRMHKLNMTLEIELGCTGGEEDGIDHHHLDRSLLYTNPEDITYAYEKLHIISPRFIIAASFGNVHGVYKPGNIRLDPK
ILQKSQKYVSNKFGLPDNFLNLVFHGGSGSTEEEIKEAISYGVVKMNIDTDIQWATWEGILKYYQHNKSFLQTQLGNPYG
NDQPNKKFYDPRIWIRAGQKSMVKYLEKIFYTLNAVNIL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=360, Percent_Identity=68.0555555555556, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI87082041, Length=335, Percent_Identity=25.3731343283582, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788072, Length=272, Percent_Identity=25.3676470588235, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=353, Percent_Identity=45.8923512747875, Blast_Score=333, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 40481; Mature: 40349

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILDFTKPGVVTGNNVQKIFDFAKKNNFALPAVNCIGMDSINAALESAANMQSPIILQ
CCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEE
FSKKGSAFMAGYGLNSDKNDHNTAVLGAVSGSLHVHHISKHYGIPVILHTDHCTKKNLPW
ECCCCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEEHHHCCCEEEEECCCCCCCCCCH
INTLLDLGAKHFYETGSPLFSSHMIDLSEESLKENIEISSQYLSRMHKLNMTLEIELGCT
HHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
GGEEDGIDHHHLDRSLLYTNPEDITYAYEKLHIISPRFIIAASFGNVHGVYKPGNIRLDP
CCCCCCCCHHHCCCEEEEECCCHHHHHHHEEEEECCCEEEEEECCCCCEEECCCCEEECH
KILQKSQKYVSNKFGLPDNFLNLVFHGGSGSTEEEIKEAISYGVVKMNIDTDIQWATWEG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCEEEEECCCCCEEHHHHH
ILKYYQHNKSFLQTQLGNPYGNDQPNKKFYDPRIWIRAGQKSMVKYLEKIFYTLNAVNIL
HHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKILDFTKPGVVTGNNVQKIFDFAKKNNFALPAVNCIGMDSINAALESAANMQSPIILQ
CCCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEE
FSKKGSAFMAGYGLNSDKNDHNTAVLGAVSGSLHVHHISKHYGIPVILHTDHCTKKNLPW
ECCCCCEEEEECCCCCCCCCCCEEEEEEECCCEEEEEEHHHCCCEEEEECCCCCCCCCCH
INTLLDLGAKHFYETGSPLFSSHMIDLSEESLKENIEISSQYLSRMHKLNMTLEIELGCT
HHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
GGEEDGIDHHHLDRSLLYTNPEDITYAYEKLHIISPRFIIAASFGNVHGVYKPGNIRLDP
CCCCCCCCHHHCCCEEEEECCCHHHHHHHEEEEECCCEEEEEECCCCCEEECCCCEEECH
KILQKSQKYVSNKFGLPDNFLNLVFHGGSGSTEEEIKEAISYGVVKMNIDTDIQWATWEG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCEEEEECCCCCEEHHHHH
ILKYYQHNKSFLQTQLGNPYGNDQPNKKFYDPRIWIRAGQKSMVKYLEKIFYTLNAVNIL
HHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]