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The map label for this gene is clpP

Identifier: 71892027

GI number: 71892027

Start: 287418

End: 288044

Strand: Direct

Name: clpP

Synonym: BPEN_253

Alternate gene names: 71892027

Gene position: 287418-288044 (Clockwise)

Preceding gene: 71892020

Following gene: 71892028

Centisome position: 36.31

GC content: 33.33

Gene sequence:

>627_bases
ATGCAATGTTCACATAACTTTAAAACGCCTTATTGTCATCGTATGGTAGTAGTTCCAACAGTAATAGAGCATACTATTCG
AGGAGATCGTGTATACGATATATTTTCTTTATTATTAAAAGAAAGAATTATTTTTATGACAGGAACTATCGAAGATAGTG
TAGCCAATTTAATTGTTGCTCAAATGATGTTCTTAGAATCAGAGAATTCAGAAAAAGACATCCATTTGTATATTAACTCT
CCAGGAGGAGTAATAACCGCGGGAATGTCAATATACGATACTATACAATTTGTAAGACCTGATGTTAGTACGTTTTGCAT
GGGACAAGCTGCATCCATGAGCGCTTTCCTATTAGCTTCTGGTACCAAAGGTAAACGATTTTGTTTACCGAATGCTCGAA
TAATGATTCACCAACCATTAGGATCTTTCCAAGGACAAGCTACTGATATTGCTATTCATACCAGAGAAATATTAAAAATT
AAAAATAATATCAACAAGCTTATGGCAAAACATACCGGACAATCTATTGATATCATCAATAAAGATACAGAACGAGATTG
TTTTTTATCTGCTGATGAAGCAATGAAGTATGGATTGGTAGATTGTGTGTTATCTCAACGAATATAA

Upstream 100 bases:

>100_bases
TAAATTTAGTTTGAAATTTTTCATAAATTGTATTATATCAAGGTTTAAATAAAACTTTTATATAACAGATATACAATACA
AGAGGATTATAATACATGCT

Downstream 100 bases:

>100_bases
ATTTAAATTATTACTTAATTTACGTTTCATTATCATCATGATCTGTAATAAAATTTATGTCTGAATTTGTTATTTATATC
TCAAGTAATTTATAGATTGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVAQMMFLESENSEKDIHLYINS
PGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLASGTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKI
KNNINKLMAKHTGQSIDIINKDTERDCFLSADEAMKYGLVDCVLSQRI

Sequences:

>Translated_208_residues
MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVAQMMFLESENSEKDIHLYINS
PGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLASGTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKI
KNNINKLMAKHTGQSIDIINKDTERDCFLSADEAMKYGLVDCVLSQRI
>Mature_208_residues
MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVAQMMFLESENSEKDIHLYINS
PGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLASGTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKI
KNNINKLMAKHTGQSIDIINKDTERDCFLSADEAMKYGLVDCVLSQRI

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=203, Percent_Identity=52.2167487684729, Blast_Score=232, Evalue=2e-61,
Organism=Escherichia coli, GI1786641, Length=197, Percent_Identity=71.0659898477157, Blast_Score=308, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=49.468085106383, Blast_Score=205, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=54.7872340425532, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_BLOPB (Q493F8)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277757.1
- ProteinModelPortal:   Q493F8
- SMR:   Q493F8
- STRING:   Q493F8
- MEROPS:   S14.001
- GeneID:   3562802
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_253
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KHDINKI
- BioCyc:   CBLO291272:BPEN_253-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23325; Mature: 23325

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 112-112 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVA
CCCCCCCCCCCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
QMMFLESENSEKDIHLYINSPGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLAS
HHHHHHCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEC
GTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKIKNNINKLMAKHTGQSIDIIN
CCCCCEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEC
KDTERDCFLSADEAMKYGLVDCVLSQRI
CCCCCCEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVA
CCCCCCCCCCCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
QMMFLESENSEKDIHLYINSPGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLAS
HHHHHHCCCCCCEEEEEEECCCCEEEECHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEC
GTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKIKNNINKLMAKHTGQSIDIIN
CCCCCEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEC
KDTERDCFLSADEAMKYGLVDCVLSQRI
CCCCCCEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA