Definition Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome.
Accession NC_007292
Length 791,654

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The map label for this gene is murB

Identifier: 71891970

GI number: 71891970

Start: 238230

End: 239267

Strand: Direct

Name: murB

Synonym: BPEN_189

Alternate gene names: 71891970

Gene position: 238230-239267 (Clockwise)

Preceding gene: 71891969

Following gene: 71891971

Centisome position: 30.09

GC content: 29.38

Gene sequence:

>1038_bases
ATGTATGAGCATCCTTTTCAATTAAAATCATTAAATACCTTTTCAGTTAACGCATTTGCTAAAAGTGTAGTAACAGCACA
TCATGAACATACGTTATTAAAGTTTTGGAGGAAAGCTTATCGAAAAGGAAAACCTGTTCTTATTTTAGGAGGCGGTAGTA
ATATTTTATTTTTAGAAAACTATTCTGGAACAATATTATTAAATAGGATAAAGGGTATTTTTATTACAGAAAATGAAACG
GCATGGCAACTACATGTTGGAGCTGGAGAAAAATGGGACGAATTAGTAGTTCATACTATCAAAAAAAATATACCGGGGCT
AGAAAATTTAGCATGTATTCCAGGGTATGTGGGGGCTGCTCCAATTCAAAATATTGGGGCTTACGGCGTTGAGTTATCTC
AAATATGTGAGTATGTAGATGCTATAGATTTATATAGTGGAAAAAAAATTCGGTTTACTTGTTCTGAATGTGATTTCAAA
TATAGAGATAGTATTTTTAGAAATTGTTTGGAGAAATATGCTATTGTATCTGTAGGATTAAGATTATGTAAAAAGTGGAA
ACCCATATTAGATTATCATGAATTAGCTCATTTAGAAAAATTTCATATTACCCCCCGTCAAATTTTTAACTTTATTTATA
TAATTAGACATAAAAAATTACCAGATCCTGTTTTAGTGGGAAATGCTGGTAGTTTTTTTAAAAATCCAATAATAGATATT
AAAACAGCACGCTGTTTATTTCAAATTTATCCAAATATGCCTTATTTTTATCAAAAAGATGGTAGAATAAAATTATCAGC
AGGATGGTTAATAGAATATTGTCAACTAAAAGGTTATATTTTTGGGGAAGCAGCAATATATCCTAAACAGGCATTAGTAT
TAATTAATAGCAAAAAAATAGCTACTGGCACTGAAATTGCCGCATTAGCTCTTTACATATATAATAAGGTTGCAGATCAG
TTTAATATTTATTTACAACCTGAAGTTAGATTAATTGGTAATTATGGAGAAATAAATCCAAAAAAATTGTTCATGTAG

Upstream 100 bases:

>100_bases
TATATTTTTAGTATAATTGAAATTATGGATCGATGTGTGAATAAAACTCAATAATTATTATAAAAATAATATATCAAATA
TTTTTGTTTAAAATAAATAA

Downstream 100 bases:

>100_bases
TAAATAATTGATATATAAATTTTATTTAATAAATTTGAAATTAAATATATTTCTAATAATTTTTATCTTAAAATAGAATT
AAAAATATATTTACGTAGTA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MYEHPFQLKSLNTFSVNAFAKSVVTAHHEHTLLKFWRKAYRKGKPVLILGGGSNILFLENYSGTILLNRIKGIFITENET
AWQLHVGAGEKWDELVVHTIKKNIPGLENLACIPGYVGAAPIQNIGAYGVELSQICEYVDAIDLYSGKKIRFTCSECDFK
YRDSIFRNCLEKYAIVSVGLRLCKKWKPILDYHELAHLEKFHITPRQIFNFIYIIRHKKLPDPVLVGNAGSFFKNPIIDI
KTARCLFQIYPNMPYFYQKDGRIKLSAGWLIEYCQLKGYIFGEAAIYPKQALVLINSKKIATGTEIAALALYIYNKVADQ
FNIYLQPEVRLIGNYGEINPKKLFM

Sequences:

>Translated_345_residues
MYEHPFQLKSLNTFSVNAFAKSVVTAHHEHTLLKFWRKAYRKGKPVLILGGGSNILFLENYSGTILLNRIKGIFITENET
AWQLHVGAGEKWDELVVHTIKKNIPGLENLACIPGYVGAAPIQNIGAYGVELSQICEYVDAIDLYSGKKIRFTCSECDFK
YRDSIFRNCLEKYAIVSVGLRLCKKWKPILDYHELAHLEKFHITPRQIFNFIYIIRHKKLPDPVLVGNAGSFFKNPIIDI
KTARCLFQIYPNMPYFYQKDGRIKLSAGWLIEYCQLKGYIFGEAAIYPKQALVLINSKKIATGTEIAALALYIYNKVADQ
FNIYLQPEVRLIGNYGEINPKKLFM
>Mature_345_residues
MYEHPFQLKSLNTFSVNAFAKSVVTAHHEHTLLKFWRKAYRKGKPVLILGGGSNILFLENYSGTILLNRIKGIFITENET
AWQLHVGAGEKWDELVVHTIKKNIPGLENLACIPGYVGAAPIQNIGAYGVELSQICEYVDAIDLYSGKKIRFTCSECDFK
YRDSIFRNCLEKYAIVSVGLRLCKKWKPILDYHELAHLEKFHITPRQIFNFIYIIRHKKLPDPVLVGNAGSFFKNPIIDI
KTARCLFQIYPNMPYFYQKDGRIKLSAGWLIEYCQLKGYIFGEAAIYPKQALVLINSKKIATGTEIAALALYIYNKVADQ
FNIYLQPEVRLIGNYGEINPKKLFM

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=333, Percent_Identity=52.2522522522522, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_BLOPB (Q493L3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277700.1
- ProteinModelPortal:   Q493L3
- SMR:   Q493L3
- STRING:   Q493L3
- GeneID:   3562908
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_189
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK00046
- BioCyc:   CBLO291272:BPEN_189-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 39502; Mature: 39502

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 162-162 ACT_SITE 231-231 ACT_SITE 328-328

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MYEHPFQLKSLNTFSVNAFAKSVVTAHHEHTLLKFWRKAYRKGKPVLILGGGSNILFLEN
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
YSGTILLNRIKGIFITENETAWQLHVGAGEKWDELVVHTIKKNIPGLENLACIPGYVGAA
CCCEEEEEECCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCC
PIQNIGAYGVELSQICEYVDAIDLYSGKKIRFTCSECDFKYRDSIFRNCLEKYAIVSVGL
CHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RLCKKWKPILDYHELAHLEKFHITPRQIFNFIYIIRHKKLPDPVLVGNAGSFFKNPIIDI
HHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCCCCEEECCCCCHHCCCCEEE
KTARCLFQIYPNMPYFYQKDGRIKLSAGWLIEYCQLKGYIFGEAAIYPKQALVLINSKKI
HHHHHHHHHCCCCCEEEECCCEEEEECCHHHEEEHHCCEEEECEEECCCEEEEEEECCCC
ATGTEIAALALYIYNKVADQFNIYLQPEVRLIGNYGEINPKKLFM
CCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MYEHPFQLKSLNTFSVNAFAKSVVTAHHEHTLLKFWRKAYRKGKPVLILGGGSNILFLEN
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEC
YSGTILLNRIKGIFITENETAWQLHVGAGEKWDELVVHTIKKNIPGLENLACIPGYVGAA
CCCEEEEEECCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCC
PIQNIGAYGVELSQICEYVDAIDLYSGKKIRFTCSECDFKYRDSIFRNCLEKYAIVSVGL
CHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RLCKKWKPILDYHELAHLEKFHITPRQIFNFIYIIRHKKLPDPVLVGNAGSFFKNPIIDI
HHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCCCCCEEECCCCCHHCCCCEEE
KTARCLFQIYPNMPYFYQKDGRIKLSAGWLIEYCQLKGYIFGEAAIYPKQALVLINSKKI
HHHHHHHHHCCCCCEEEECCCEEEEECCHHHEEEHHCCEEEECEEECCCEEEEEEECCCC
ATGTEIAALALYIYNKVADQFNIYLQPEVRLIGNYGEINPKKLFM
CCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA