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The map label for this gene is trxC [H]

Identifier: 68537189

GI number: 68537189

Start: 2452847

End: 2453170

Strand: Direct

Name: trxC [H]

Synonym: jk2094

Alternate gene names: 68537189

Gene position: 2452847-2453170 (Clockwise)

Preceding gene: 68537188

Following gene: 68537190

Centisome position: 99.61

GC content: 56.48

Gene sequence:

>324_bases
ATGTCCGACATTGTGAACGTCACCCAGACTACCTTTAGGTCCGAGGTCGTCGAGTCTACTCAGCCTGTTCTTGTCGACTT
CTGGGCCGAATGGTGCCGCCCTTGCCTAGCAATGACGCCCATTCTCGACGAGCTGGCGGCGGAGTTCGATGGCAAGGCGA
AGATCGCCAAGGTGAACGTCGATGAGGAGCGCATGCTGGGGGCAATGTTCCAGGTCATGTCTATTCCCGCTCTTATGGTT
TTCAAGGACGGGGAGAAGGTAGCAGAGTTCACCGGTGCTCAGGATCGGGATACGCTACGGTCCGCAATTGAAGCGCAGCT
TTAG

Upstream 100 bases:

>100_bases
CGTTAGGTAACTATGGCCGGTCGGACATAGGATATTTAAACGTTGAAGGGTAACCTCCAACCTAAAGGAAAAGCCCCCAA
CCAGAAGGTTTATCGCCGCC

Downstream 100 bases:

>100_bases
GATCCGTCTGATCTAACACGCCTGACCTGCAAGTAAAGCAAATCGGCGGATTTGTCCCTAGAATTGCACCTATGACTCGC
CACTGTCGGCGATAGACCCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSDIVNVTQTTFRSEVVESTQPVLVDFWAEWCRPCLAMTPILDELAAEFDGKAKIAKVNVDEERMLGAMFQVMSIPALMV
FKDGEKVAEFTGAQDRDTLRSAIEAQL

Sequences:

>Translated_107_residues
MSDIVNVTQTTFRSEVVESTQPVLVDFWAEWCRPCLAMTPILDELAAEFDGKAKIAKVNVDEERMLGAMFQVMSIPALMV
FKDGEKVAEFTGAQDRDTLRSAIEAQL
>Mature_106_residues
SDIVNVTQTTFRSEVVESTQPVLVDFWAEWCRPCLAMTPILDELAAEFDGKAKIAKVNVDEERMLGAMFQVMSIPALMVF
KDGEKVAEFTGAQDRDTLRSAIEAQL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=36.5591397849462, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI42794771, Length=106, Percent_Identity=32.0754716981132, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI224493972, Length=106, Percent_Identity=32.0754716981132, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=40.7407407407407, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=103, Percent_Identity=35.9223300970874, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=35.8490566037736, Blast_Score=82, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=39.7849462365591, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=78, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=37.6344086021505, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358065, Length=94, Percent_Identity=39.3617021276596, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=34.4086021505376, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859803, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=35.9550561797753, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=35.9550561797753, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=32.8947368421053, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11944; Mature: 11813

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVNVTQTTFRSEVVESTQPVLVDFWAEWCRPCLAMTPILDELAAEFDGKAKIAKVNV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DEERMLGAMFQVMSIPALMVFKDGEKVAEFTGAQDRDTLRSAIEAQL
CHHHHHHHHHHHHHCCHHEEEECCHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDIVNVTQTTFRSEVVESTQPVLVDFWAEWCRPCLAMTPILDELAAEFDGKAKIAKVNV
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DEERMLGAMFQVMSIPALMVFKDGEKVAEFTGAQDRDTLRSAIEAQL
CHHHHHHHHHHHHHCCHHEEEECCHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]