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The map label for this gene is clpP2

Identifier: 68535617

GI number: 68535617

Start: 661066

End: 661695

Strand: Direct

Name: clpP2

Synonym: jk0545

Alternate gene names: 68535617

Gene position: 661066-661695 (Clockwise)

Preceding gene: 68535616

Following gene: 68535618

Centisome position: 26.85

GC content: 63.65

Gene sequence:

>630_bases
ATGTCAGAGATGCAGATGCCAGAAATGCGATACATCCTGCCGTCGTTCGTGGAGCACTCCAGCTACGGCGCGAAGGAATC
CAACCCGTACAACAAGCTGTTCGAGGAGCGCATCATCTTCCTGGGTACCCAGGTGGACGACGCTTCCGCCAACGACATCA
TGGCGCAGCTGCTGGTGCTGGAGGGGTTGGACCCGGACCGGGACATCACGATGTACATCAACTCTCCCGGCGGTTCCTTC
ACCAGCCTGATGGCTATCTACGACACGATGCAGTACGTCCGCCCGGACGTGCAGACCGTCTGCCTCGGCCAGGCCGCCAG
CGCGGCTGCTGTGCTGCTGGCCGCCGGTACCCCGGGCAAGCGCGCTGCCCTGCCGAACGCCCGCGTGCTGATTCACCAGC
CCGCCACCGGCGGTGTGCAGGGCCAGGTTTCCGACCTGGAGATCCAGGCCAAGGAGATCGAGCGCATGCGCAAGCTGATG
GAAGAGACCCTGGCACGCCACACCGGCAAGTCCGCCGAGCAGGTACGCATCGACACCGACCGTGACAAGATCCTAACGGC
CGAGGAGGCCAAGGAGTACGGCATCGTCGACCAGGTCTTCGACTACCGCAAGCTGTCGGCGCAGAACTAG

Upstream 100 bases:

>100_bases
CACCAAGGATTCCGACCGCGACCGTTGGTTCACCGCCCAGCAGGCCAAGGAATACGGTTTCGTCGACCACGTCATCACCT
CTGCGAAGGAGAGCTAAGAC

Downstream 100 bases:

>100_bases
CGCCCGGCAAACACTAGCGACCCGCGGGGCTTTCAGCTTCCGCGGGGTTTTTGGTGTGGCGCAGTAGAATTGAAGGCCTA
CGAGGGTGCTAATCTAGCTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSEMQMPEMRYILPSFVEHSSYGAKESNPYNKLFEERIIFLGTQVDDASANDIMAQLLVLEGLDPDRDITMYINSPGGSF
TSLMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGTPGKRAALPNARVLIHQPATGGVQGQVSDLEIQAKEIERMRKLM
EETLARHTGKSAEQVRIDTDRDKILTAEEAKEYGIVDQVFDYRKLSAQN

Sequences:

>Translated_209_residues
MSEMQMPEMRYILPSFVEHSSYGAKESNPYNKLFEERIIFLGTQVDDASANDIMAQLLVLEGLDPDRDITMYINSPGGSF
TSLMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGTPGKRAALPNARVLIHQPATGGVQGQVSDLEIQAKEIERMRKLM
EETLARHTGKSAEQVRIDTDRDKILTAEEAKEYGIVDQVFDYRKLSAQN
>Mature_208_residues
SEMQMPEMRYILPSFVEHSSYGAKESNPYNKLFEERIIFLGTQVDDASANDIMAQLLVLEGLDPDRDITMYINSPGGSFT
SLMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGTPGKRAALPNARVLIHQPATGGVQGQVSDLEIQAKEIERMRKLME
ETLARHTGKSAEQVRIDTDRDKILTAEEAKEYGIVDQVFDYRKLSAQN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=189, Percent_Identity=43.9153439153439, Blast_Score=175, Evalue=3e-44,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=52.3316062176166, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=42.6315789473684, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=42.4083769633508, Blast_Score=173, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_CORJK (Q4JWV3)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250322.1
- ProteinModelPortal:   Q4JWV3
- SMR:   Q4JWV3
- STRING:   Q4JWV3
- MEROPS:   S14.009
- GeneID:   3432180
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0545
- NMPDR:   fig|306537.3.peg.541
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   QDPYTKL
- ProtClustDB:   PRK12553
- BioCyc:   CJEI306537:JK0545-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23162; Mature: 23030

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMQMPEMRYILPSFVEHSSYGAKESNPYNKLFEERIIFLGTQVDDASANDIMAQLLVL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
EGLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGTPGK
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHEEEEEECCCCCC
RAALPNARVLIHQPATGGVQGQVSDLEIQAKEIERMRKLMEETLARHTGKSAEQVRIDTD
CCCCCCCEEEEECCCCCCCCCCCHHHEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
RDKILTAEEAKEYGIVDQVFDYRKLSAQN
CCCEEEHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEMQMPEMRYILPSFVEHSSYGAKESNPYNKLFEERIIFLGTQVDDASANDIMAQLLVL
CCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
EGLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRPDVQTVCLGQAASAAAVLLAAGTPGK
HCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHEEEEEECCCCCC
RAALPNARVLIHQPATGGVQGQVSDLEIQAKEIERMRKLMEETLARHTGKSAEQVRIDTD
CCCCCCCEEEEECCCCCCCCCCCHHHEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
RDKILTAEEAKEYGIVDQVFDYRKLSAQN
CCCEEEHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA