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The map label for this gene is clpP

Identifier: 68535616

GI number: 68535616

Start: 660496

End: 661062

Strand: Direct

Name: clpP

Synonym: jk0544

Alternate gene names: 68535616

Gene position: 660496-661062 (Clockwise)

Preceding gene: 68535615

Following gene: 68535617

Centisome position: 26.82

GC content: 62.26

Gene sequence:

>567_bases
TTGAGTTCGGAAACCCCAAACCATAGAGACTCAGTCTACGAGCGCCTGCTGCGCGAGCGAATCATCTTCCTGGGCAGCCA
GGTGGACGATGAGATCGCCAATGAGCTGTGCGCCCAGATTCTGCTGCTGTCCGCAGAGGATCCGACGCGCGACATCAGCC
TGTACATCAACTCTCCCGGTGGCTCCGTCACCGCGGGTATGGCTATCTACGACACGATGAAGTACGCGCCGTGCGACATC
GCTACCTACGGGATGGGCCTGGCGGCGTCCATGGGCCAGTTCCTGCTTTCCGCAGGCACGAAGGGTAAGCGCTACGCCCT
GCCGCACGCCCGCATCATGATGCACCAGCCTTCCGCAGGCGTGGGCGGCACCGCCGCCGACATCGCCATCCAGGCGGAGC
AGTTCGCTTACACCAAGCGGGAGATGGCGGAGCTGATCGCGGAGTTCACCGGCCAGACCGTTGAGCAGATCACCAAGGAT
TCCGACCGCGACCGTTGGTTCACCGCCCAGCAGGCCAAGGAATACGGTTTCGTCGACCACGTCATCACCTCTGCGAAGGA
GAGCTAA

Upstream 100 bases:

>100_bases
GCGAACAACCCCACCGGAAGGCACGCTTTGCCGACGGGTGTGACTAGGCTGGGGCGCATACAAAAGTGAACTTTCGTAAA
ACTTTCGGCAAGGAGCGAAG

Downstream 100 bases:

>100_bases
GACATGTCAGAGATGCAGATGCCAGAAATGCGATACATCCTGCCGTCGTTCGTGGAGCACTCCAGCTACGGCGCGAAGGA
ATCCAACCCGTACAACAAGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSSETPNHRDSVYERLLRERIIFLGSQVDDEIANELCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMKYAPCDI
ATYGMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSAGVGGTAADIAIQAEQFAYTKREMAELIAEFTGQTVEQITKD
SDRDRWFTAQQAKEYGFVDHVITSAKES

Sequences:

>Translated_188_residues
MSSETPNHRDSVYERLLRERIIFLGSQVDDEIANELCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMKYAPCDI
ATYGMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSAGVGGTAADIAIQAEQFAYTKREMAELIAEFTGQTVEQITKD
SDRDRWFTAQQAKEYGFVDHVITSAKES
>Mature_187_residues
SSETPNHRDSVYERLLRERIIFLGSQVDDEIANELCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMKYAPCDIA
TYGMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSAGVGGTAADIAIQAEQFAYTKREMAELIAEFTGQTVEQITKDS
DRDRWFTAQQAKEYGFVDHVITSAKES

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=176, Percent_Identity=46.5909090909091, Blast_Score=175, Evalue=2e-44,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=55.2325581395349, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17538017, Length=172, Percent_Identity=49.4186046511628, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI20129427, Length=177, Percent_Identity=46.3276836158192, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_CORJK (Q4JWV4)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250321.1
- ProteinModelPortal:   Q4JWV4
- SMR:   Q4JWV4
- STRING:   Q4JWV4
- MEROPS:   S14.008
- GeneID:   3432179
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0544
- NMPDR:   fig|306537.3.peg.540
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   CJEI306537:JK0544-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 20639; Mature: 20507

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 90-90 ACT_SITE 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSETPNHRDSVYERLLRERIIFLGSQVDDEIANELCAQILLLSAEDPTRDISLYINSPG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
GSVTAGMAIYDTMKYAPCDIATYGMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSAG
CCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCC
VGGTAADIAIQAEQFAYTKREMAELIAEFTGQTVEQITKDSDRDRWFTAQQAKEYGFVDH
CCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHH
VITSAKES
HHHHCCCC
>Mature Secondary Structure 
SSETPNHRDSVYERLLRERIIFLGSQVDDEIANELCAQILLLSAEDPTRDISLYINSPG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
GSVTAGMAIYDTMKYAPCDIATYGMGLAASMGQFLLSAGTKGKRYALPHARIMMHQPSAG
CCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCC
VGGTAADIAIQAEQFAYTKREMAELIAEFTGQTVEQITKDSDRDRWFTAQQAKEYGFVDH
CCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHH
VITSAKES
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA