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The map label for this gene is purC [H]

Identifier: 68535415

GI number: 68535415

Start: 420629

End: 421552

Strand: Direct

Name: purC [H]

Synonym: jk0350

Alternate gene names: 68535415

Gene position: 420629-421552 (Clockwise)

Preceding gene: 68535414

Following gene: 68535416

Centisome position: 17.08

GC content: 63.74

Gene sequence:

>924_bases
ATGCCTGGTACAGGGCTACACTGTCTACTCATGCGTCCAGAATTGTGCGAGTACGAGCACCATTCCGCAGGTAAAGTGCG
GGAGATCTATGAGGTCGACGAAGACAACCTGCTGATGGTTGTCAGCGACCGGATCAGTGCCTACGACTACGTCCTTGATA
CCGAGATCCCAGACAAGGGTCGGGTGCTCACTGCCGTGAGCGCTTTTTTCTTTGACGAGATTGATTTCCCCAACCACCTA
GCCGGTGCGATGGATGACGAGCGGATCCCCGAGTACGTCCTCGGCCGCGCCATGCTGTGCAAGAAGCTGGATATGATCCC
CTTCGAGTGCGTGGCCCGCGGCTACCTGACCGGCTCTGGCCTGAAGGAGTACCAGGAAACCGGCAGCGTGTGCGGCGTGG
AGCTGCCCGAGGGGCTCGTGGAGGCTTCCCGCCTGCCGGAGCCGATCTTCACCCCGGCCACTAAGGCGGAACTGGGCGAC
CACGACGAGAACGTGAGCTTCGACGTGGTCGTCGAGGCGCTGGGGGAGGAGCGCGCCAACGAGCTGCGCGAGGCGACCCT
CTCGATCTACAAGAAGGCTGCCGCCATCGCCGAGGAGCGCGGCCTGATTCTGGCCGACACCAAGTTCGAGTTCGGCCTGG
ATGCCGACGGCACCCTGGTGCTGGCCGACGAGGTGCTGACCCCGGACTCCTCCCGCTACTGGCCCGCCGAGGGCTACGAA
GAGGGCAAGGTGCAGCCCAGCTTCGATAAGCAGTATGTGCGCAACTGGCTAACCGGTCCGAAGTCCGGCTGGGACAAGTC
CGAGGGCACGCCCCCGCCGCCGCTGCCGGGCTCCGTGGTGGAAGCCACCCGCTCGCGCTACATCGAGGCCTACGAGAAGC
TATCCGGCAAGCGCTTCTCCGACTGGATTGGCCAGTGCGTCTAG

Upstream 100 bases:

>100_bases
GCCGGGCGAGATTCTTTAGCTGCGTACTGGTGCAGCTACTAGTGCGCTTTTAGCTGCGCAAACGCCGAAGATTCGCACAG
TTCCGGCCACAAATAGTCAA

Downstream 100 bases:

>100_bases
GCGACTGCAGTCCCAACCAATTCGGCTCCCAGTAGTCCTGTCTGAGTAGCATGGCGCGTATGCCTAATAACGACGCGCCC
CAGACAGCTAACAACCCAAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPGTGLHCLLMRPELCEYEHHSAGKVREIYEVDEDNLLMVVSDRISAYDYVLDTEIPDKGRVLTAVSAFFFDEIDFPNHL
AGAMDDERIPEYVLGRAMLCKKLDMIPFECVARGYLTGSGLKEYQETGSVCGVELPEGLVEASRLPEPIFTPATKAELGD
HDENVSFDVVVEALGEERANELREATLSIYKKAAAIAEERGLILADTKFEFGLDADGTLVLADEVLTPDSSRYWPAEGYE
EGKVQPSFDKQYVRNWLTGPKSGWDKSEGTPPPPLPGSVVEATRSRYIEAYEKLSGKRFSDWIGQCV

Sequences:

>Translated_307_residues
MPGTGLHCLLMRPELCEYEHHSAGKVREIYEVDEDNLLMVVSDRISAYDYVLDTEIPDKGRVLTAVSAFFFDEIDFPNHL
AGAMDDERIPEYVLGRAMLCKKLDMIPFECVARGYLTGSGLKEYQETGSVCGVELPEGLVEASRLPEPIFTPATKAELGD
HDENVSFDVVVEALGEERANELREATLSIYKKAAAIAEERGLILADTKFEFGLDADGTLVLADEVLTPDSSRYWPAEGYE
EGKVQPSFDKQYVRNWLTGPKSGWDKSEGTPPPPLPGSVVEATRSRYIEAYEKLSGKRFSDWIGQCV
>Mature_306_residues
PGTGLHCLLMRPELCEYEHHSAGKVREIYEVDEDNLLMVVSDRISAYDYVLDTEIPDKGRVLTAVSAFFFDEIDFPNHLA
GAMDDERIPEYVLGRAMLCKKLDMIPFECVARGYLTGSGLKEYQETGSVCGVELPEGLVEASRLPEPIFTPATKAELGDH
DENVSFDVVVEALGEERANELREATLSIYKKAAAIAEERGLILADTKFEFGLDADGTLVLADEVLTPDSSRYWPAEGYEE
GKVQPSFDKQYVRNWLTGPKSGWDKSEGTPPPPLPGSVVEATRSRYIEAYEKLSGKRFSDWIGQCV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=241, Percent_Identity=28.2157676348548, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319326, Length=293, Percent_Identity=44.7098976109215, Blast_Score=253, Evalue=2e-68,
Organism=Drosophila melanogaster, GI18860083, Length=242, Percent_Identity=26.8595041322314, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 34144; Mature: 34013

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTGLHCLLMRPELCEYEHHSAGKVREIYEVDEDNLLMVVSDRISAYDYVLDTEIPDKG
CCCCCEEEEEECCHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCHHHEEEECCCCCCC
RVLTAVSAFFFDEIDFPNHLAGAMDDERIPEYVLGRAMLCKKLDMIPFECVARGYLTGSG
CHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCH
LKEYQETGSVCGVELPEGLVEASRLPEPIFTPATKAELGDHDENVSFDVVVEALGEERAN
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHH
ELREATLSIYKKAAAIAEERGLILADTKFEFGLDADGTLVLADEVLTPDSSRYWPAEGYE
HHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCC
EGKVQPSFDKQYVRNWLTGPKSGWDKSEGTPPPPLPGSVVEATRSRYIEAYEKLSGKRFS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
DWIGQCV
HHHHHCC
>Mature Secondary Structure 
PGTGLHCLLMRPELCEYEHHSAGKVREIYEVDEDNLLMVVSDRISAYDYVLDTEIPDKG
CCCCEEEEEECCHHHCCCCCCCCCHHHHHHCCCCCEEEEECCCCCHHHEEEECCCCCCC
RVLTAVSAFFFDEIDFPNHLAGAMDDERIPEYVLGRAMLCKKLDMIPFECVARGYLTGSG
CHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCH
LKEYQETGSVCGVELPEGLVEASRLPEPIFTPATKAELGDHDENVSFDVVVEALGEERAN
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHH
ELREATLSIYKKAAAIAEERGLILADTKFEFGLDADGTLVLADEVLTPDSSRYWPAEGYE
HHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCC
EGKVQPSFDKQYVRNWLTGPKSGWDKSEGTPPPPLPGSVVEATRSRYIEAYEKLSGKRFS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
DWIGQCV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA