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The map label for this gene is mntH1 [H]

Identifier: 68535078

GI number: 68535078

Start: 22211

End: 23395

Strand: Direct

Name: mntH1 [H]

Synonym: jk0016

Alternate gene names: 68535078

Gene position: 22211-23395 (Clockwise)

Preceding gene: 68535077

Following gene: 68535079

Centisome position: 0.9

GC content: 66.92

Gene sequence:

>1185_bases
ATGCGTAAGACCTTAATCAGCCTCACCGGCCCCGCCTTCGTTGCTGCAGTGGCTTACGTCGACCCCGGCAACGTAGCCGC
CAACATCAGCGCCGGCTCCCACTACGGCTACCTCCTGGTGTGGGTACTCGTCGTGGCCAACCTCATGGCCATGTTCATCC
AGTACCACTCCGCCAAACTGGGCCTAGTCACCCACCGCTCCCTGCCGGAAATCATGGGCGAGCGTCTCTCCCGCCGCGCG
CGCCTAGGCATGTGGGCCCAGGCCGAGCTCATCGCCGCGGCCACCGACCTCGCCGAAGTCATCGGCGGCGCCATTGCCCT
GCAACTCCTCTTCAACCTCCCCCTGTTCGCGGGCGCGCTCATCATCGGCGCGGTCTCCATCATTCTCCTCATCTTCCAGA
AGAAGAACCAGTGGTTCGAGGGGCTTGTCATCGGCCTGCTCCTGGTCATCTGCATCGGCTTCCTTGCCGGCCTCGCCATC
GCCCCGCCCGACCCCGCCGACGTGGCCGGCGGCCTCATCCCCCGCCTAGAGGGCAAGGACAGCATCCTGCTGGCCGCCTC
CATGTTGGGCGCCACCGTCATGCCGCACGCCATTTACCTACACTCCTCCCTGACCAAGCAGCGCTACCCCGACCTGGAAA
TCCCCCACGTGCTGGCCGGCACCCGCGCGGACATCGCCGTGGCGCTGTCCATCGCCGGGCTCGTCAACGTGGGCCTGCTG
GTCCTGGCGGGCTCGGCCCTCTACGGCGTGGACGGCACAGAGACCATCTCCGGGGCCCACACGGCGATTGCCAGCCACCT
CGGCCCGCTGGCCGGCGTTCTCTTCGCCATCGGCCTGCTGGCCAGCGGCCTCGCCTCGACGTCAGTGGGCGCCTACGCCG
GCTCCGAAATCATGGACGGCCTGCTTCACATCAAGGTCCCCCTACTAGTCCGCCGCCTGGTCACGCTCATCCCGGCGCTG
GTCATCATCGGCTGCGGGGTCGACCCCACTATGGCACTGGTGGTCAGCCAGGCACTTCTTTCCCTGGGCATCCCCTTCGC
CATCATCCCGCTTTTCCGCTATGCCGGCTCCCGGGACGTCATGGGTGAGTTCGCCGCGAAACCCTGGTCTATGGCCGTGG
GCTGGACGCTTGCCGCGCTGGTCATCGCACTCAATCTCGCCCTCGTGCTCCTGCCGCTGCTCTAG

Upstream 100 bases:

>100_bases
AAGCGTGGCGCATCCACCGCTTGATTCCGCCCCCCTGGCTTGAACATATGGCGATGAAAACTAGACTTCAAGTAGTTGAA
CTTTTGGTATGGAGATGCCT

Downstream 100 bases:

>100_bases
GCCGCCTACAATCAGCAGCCATGATTGAAGTAGCAGCCGTCGTCATCCGCAACCCACAAGGCCACGTGCTTACCGTGCGC
AAGAAGTCCTCCACCAAGTA

Product: manganese transporter NRAMP

Products: NA

Alternate protein names: BRAMP [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRKTLISLTGPAFVAAVAYVDPGNVAANISAGSHYGYLLVWVLVVANLMAMFIQYHSAKLGLVTHRSLPEIMGERLSRRA
RLGMWAQAELIAAATDLAEVIGGAIALQLLFNLPLFAGALIIGAVSIILLIFQKKNQWFEGLVIGLLLVICIGFLAGLAI
APPDPADVAGGLIPRLEGKDSILLAASMLGATVMPHAIYLHSSLTKQRYPDLEIPHVLAGTRADIAVALSIAGLVNVGLL
VLAGSALYGVDGTETISGAHTAIASHLGPLAGVLFAIGLLASGLASTSVGAYAGSEIMDGLLHIKVPLLVRRLVTLIPAL
VIIGCGVDPTMALVVSQALLSLGIPFAIIPLFRYAGSRDVMGEFAAKPWSMAVGWTLAALVIALNLALVLLPLL

Sequences:

>Translated_394_residues
MRKTLISLTGPAFVAAVAYVDPGNVAANISAGSHYGYLLVWVLVVANLMAMFIQYHSAKLGLVTHRSLPEIMGERLSRRA
RLGMWAQAELIAAATDLAEVIGGAIALQLLFNLPLFAGALIIGAVSIILLIFQKKNQWFEGLVIGLLLVICIGFLAGLAI
APPDPADVAGGLIPRLEGKDSILLAASMLGATVMPHAIYLHSSLTKQRYPDLEIPHVLAGTRADIAVALSIAGLVNVGLL
VLAGSALYGVDGTETISGAHTAIASHLGPLAGVLFAIGLLASGLASTSVGAYAGSEIMDGLLHIKVPLLVRRLVTLIPAL
VIIGCGVDPTMALVVSQALLSLGIPFAIIPLFRYAGSRDVMGEFAAKPWSMAVGWTLAALVIALNLALVLLPLL
>Mature_394_residues
MRKTLISLTGPAFVAAVAYVDPGNVAANISAGSHYGYLLVWVLVVANLMAMFIQYHSAKLGLVTHRSLPEIMGERLSRRA
RLGMWAQAELIAAATDLAEVIGGAIALQLLFNLPLFAGALIIGAVSIILLIFQKKNQWFEGLVIGLLLVICIGFLAGLAI
APPDPADVAGGLIPRLEGKDSILLAASMLGATVMPHAIYLHSSLTKQRYPDLEIPHVLAGTRADIAVALSIAGLVNVGLL
VLAGSALYGVDGTETISGAHTAIASHLGPLAGVLFAIGLLASGLASTSVGAYAGSEIMDGLLHIKVPLLVRRLVTLIPAL
VIIGCGVDPTMALVVSQALLSLGIPFAIIPLFRYAGSRDVMGEFAAKPWSMAVGWTLAALVIALNLALVLLPLL

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=447, Percent_Identity=28.8590604026846, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI295293167, Length=444, Percent_Identity=27.4774774774775, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI295293178, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI295293171, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI295293169, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI295293175, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI295293173, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI10835169, Length=444, Percent_Identity=27.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1788736, Length=401, Percent_Identity=40.6483790523691, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71999499, Length=434, Percent_Identity=28.3410138248848, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17569473, Length=378, Percent_Identity=29.3650793650794, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI193210616, Length=430, Percent_Identity=26.9767441860465, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71993856, Length=407, Percent_Identity=25.3071253071253, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323062, Length=388, Percent_Identity=31.1855670103093, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6324450, Length=416, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321841, Length=400, Percent_Identity=31, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24648607, Length=439, Percent_Identity=28.246013667426, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI281362176, Length=439, Percent_Identity=28.246013667426, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24648609, Length=439, Percent_Identity=28.246013667426, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45553443, Length=410, Percent_Identity=28.5365853658537, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005025
- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF03358 FMN_red; PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 40938; Mature: 40938

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTLISLTGPAFVAAVAYVDPGNVAANISAGSHYGYLLVWVLVVANLMAMFIQYHSAKL
CCCCEEEECCHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GLVTHRSLPEIMGERLSRRARLGMWAQAELIAAATDLAEVIGGAIALQLLFNLPLFAGAL
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGAVSIILLIFQKKNQWFEGLVIGLLLVICIGFLAGLAIAPPDPADVAGGLIPRLEGKD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCC
SILLAASMLGATVMPHAIYLHSSLTKQRYPDLEIPHVLAGTRADIAVALSIAGLVNVGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
VLAGSALYGVDGTETISGAHTAIASHLGPLAGVLFAIGLLASGLASTSVGAYAGSEIMDG
HHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLHIKVPLLVRRLVTLIPALVIIGCGVDPTMALVVSQALLSLGIPFAIIPLFRYAGSRDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
MGEFAAKPWSMAVGWTLAALVIALNLALVLLPLL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKTLISLTGPAFVAAVAYVDPGNVAANISAGSHYGYLLVWVLVVANLMAMFIQYHSAKL
CCCCEEEECCHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GLVTHRSLPEIMGERLSRRARLGMWAQAELIAAATDLAEVIGGAIALQLLFNLPLFAGAL
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGAVSIILLIFQKKNQWFEGLVIGLLLVICIGFLAGLAIAPPDPADVAGGLIPRLEGKD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCC
SILLAASMLGATVMPHAIYLHSSLTKQRYPDLEIPHVLAGTRADIAVALSIAGLVNVGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
VLAGSALYGVDGTETISGAHTAIASHLGPLAGVLFAIGLLASGLASTSVGAYAGSEIMDG
HHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLHIKVPLLVRRLVTLIPALVIIGCGVDPTMALVVSQALLSLGIPFAIIPLFRYAGSRDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
MGEFAAKPWSMAVGWTLAALVIALNLALVLLPLL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972; 9632246 [H]