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The map label for this gene is proA

Identifier: 66768201

GI number: 66768201

Start: 2273540

End: 2274784

Strand: Direct

Name: proA

Synonym: XC_1880

Alternate gene names: 66768201

Gene position: 2273540-2274784 (Clockwise)

Preceding gene: 77761174

Following gene: 66768202

Centisome position: 44.16

GC content: 67.47

Gene sequence:

>1245_bases
ATGACCATCAAATCGCTCGCCCTGCAATGCCGCGACGCCGCGCAGGTGCTGTCGCAATTGTCCGCAGACGCCAAGCAGGC
CTTATTGCTGGCCATGGCCAATGCGCTCGACACCGATGCGACGCAGATTCTGCAGGCCAACCAGCGTGACGTGGATGCGG
CGCGTGAGAAGGGCACCGGTGCGGCGATGCTCGATCGCCTGACGCTGACGCCGGCGCGCTTGTCGGCAGTGGGCGCGGCG
TTGCGTGAGGTAGCCGTGCTGCCGGATCCAGTGGGCCAGGTCACGCGCGACGATGTGCGCCCCAACGGCATCCGCGTGCA
GAAGGTGCGCGTGCCGCTGGGGGTGATCGCGATGATCTACGAAGCCCGCCCCAATGTGACCGCTGATGCGGCAGCGCTGT
GCATCAAGGCCGGCAACGGCGTGATCCTGCGTGGCGGCTCCGAAGCGATTCATTCCAACACCGCGATTGCGCGCGCCCTG
CAGCGCGCCCTGCGCGAGGCCGGCGTGCCCGAAGCGGCGCTGACGCTGGTGGAAGACTTGCGGCGCGAGACCATGCTGGA
GCTGCTGCAGCTCAGCGACATCGTCGACCTGGCGATTCCGCGCGGTGGCGAAGGCCTGATCCGCTTCGTTGCCGAACACG
CGCGCGTGCCGGTGATCAAGCATTACAAGGGTGTCTGCCATCTGTTCGTGGATGCATCGGCCGATGTGGACCTGGCGGTG
CGCCTGCTGGTGGATGGCAAGGCCTCGCGGCCGTCGGCATGCAATTCGCTGGAGACCCTGCTGGTGCATGCAGACATTGC
CGAACGCTTTCTCCCCGCCGCCGCCGCTGCGTTGCGCGCGCGCAACGTCGAGCTGCGTGGCGATGCGGCAACGCGCGCAG
TGCTGCCCGAGATCGCCGCGGCCAGCGACGACGACTACGCCGCCGAATTCCTGGACCTTATCCTGGCCATCCGCGTGGTG
CCGGATCTGGACACCGCGCTGGCGCATATCCGTCAGTACGGCTCGGATCACACCGAGGTGATCGCCACGCAGACGCCCGC
CAACGCCGAAACGTTCGTGCAGTCGCTGCGCTCGGCGGTGGTGATGGTCAATGCGTCTTCGCGATTTTCCGACGGTGGCG
AACTCGGCCTGGGCGCGGAGATCGGCATCTCCACCACGCGCCTGCATTCGTACGGCCCGATGGGCCTGGAGGCGCTGACC
GTGGAGCGCTTCGTGGTGCGCGGTGAGGGGCAGGTGCGGCACTGA

Upstream 100 bases:

>100_bases
GCTTACACCCGTGGTGTTTCCGATGCTCAGACGTGAACGACGCAGTGATGCAGGCCGTTGCCATTCCCGATTCCCCACTC
CCCATTCCCGGTTGCCCCCA

Downstream 100 bases:

>100_bases
CGCCTTGGCCTGGTGCTGTCGCACAGGCCGCCAGCGCAGGCATGGTTGCAGCAGCGGGCTACGCGATGCACCGGGCCGTT
GCTCTGGCGCGGGCGATGGT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTIKSLALQCRDAAQVLSQLSADAKQALLLAMANALDTDATQILQANQRDVDAAREKGTGAAMLDRLTLTPARLSAVGAA
LREVAVLPDPVGQVTRDDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARAL
QRALREAGVPEAALTLVEDLRRETMLELLQLSDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADVDLAV
RLLVDGKASRPSACNSLETLLVHADIAERFLPAAAAALRARNVELRGDAATRAVLPEIAAASDDDYAAEFLDLILAIRVV
PDLDTALAHIRQYGSDHTEVIATQTPANAETFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALT
VERFVVRGEGQVRH

Sequences:

>Translated_414_residues
MTIKSLALQCRDAAQVLSQLSADAKQALLLAMANALDTDATQILQANQRDVDAAREKGTGAAMLDRLTLTPARLSAVGAA
LREVAVLPDPVGQVTRDDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARAL
QRALREAGVPEAALTLVEDLRRETMLELLQLSDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADVDLAV
RLLVDGKASRPSACNSLETLLVHADIAERFLPAAAAALRARNVELRGDAATRAVLPEIAAASDDDYAAEFLDLILAIRVV
PDLDTALAHIRQYGSDHTEVIATQTPANAETFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALT
VERFVVRGEGQVRH
>Mature_413_residues
TIKSLALQCRDAAQVLSQLSADAKQALLLAMANALDTDATQILQANQRDVDAAREKGTGAAMLDRLTLTPARLSAVGAAL
REVAVLPDPVGQVTRDDVRPNGIRVQKVRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQ
RALREAGVPEAALTLVEDLRRETMLELLQLSDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADVDLAVR
LLVDGKASRPSACNSLETLLVHADIAERFLPAAAAALRARNVELRGDAATRAVLPEIAAASDDDYAAEFLDLILAIRVVP
DLDTALAHIRQYGSDHTEVIATQTPANAETFVQSLRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTV
ERFVVRGEGQVRH

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=37.6811594202899, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=37.6811594202899, Blast_Score=270, Evalue=2e-72,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=44.0963855421687, Blast_Score=352, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=36.7149758454106, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=36.7149758454106, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=436, Percent_Identity=32.5688073394495, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=35.8353510895884, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_XANC8 (Q4UVI0)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242963.1
- ProteinModelPortal:   Q4UVI0
- SMR:   Q4UVI0
- STRING:   Q4UVI0
- GeneID:   3380427
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1880
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q4UVI0
- ProtClustDB:   PRK00197
- BioCyc:   XCAM314565:XC_1880-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 43957; Mature: 43826

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKSLALQCRDAAQVLSQLSADAKQALLLAMANALDTDATQILQANQRDVDAAREKGTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCC
AAMLDRLTLTPARLSAVGAALREVAVLPDPVGQVTRDDVRPNGIRVQKVRVPLGVIAMIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEEECCHHHHHHHH
EARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQRALREAGVPEAALTLVEDL
HCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RRETMLELLQLSDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADVDLAV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCEEE
RLLVDGKASRPSACNSLETLLVHADIAERFLPAAAAALRARNVELRGDAATRAVLPEIAA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHC
ASDDDYAAEFLDLILAIRVVPDLDTALAHIRQYGSDHTEVIATQTPANAETFVQSLRSAV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHE
VMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
EEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
TIKSLALQCRDAAQVLSQLSADAKQALLLAMANALDTDATQILQANQRDVDAAREKGTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCC
AAMLDRLTLTPARLSAVGAALREVAVLPDPVGQVTRDDVRPNGIRVQKVRVPLGVIAMIY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEEECCHHHHHHHH
EARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQRALREAGVPEAALTLVEDL
HCCCCCCHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RRETMLELLQLSDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADVDLAV
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCEEE
RLLVDGKASRPSACNSLETLLVHADIAERFLPAAAAALRARNVELRGDAATRAVLPEIAA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHC
ASDDDYAAEFLDLILAIRVVPDLDTALAHIRQYGSDHTEVIATQTPANAETFVQSLRSAV
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHE
VMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
EEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA