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The map label for this gene is cocE [H]

Identifier: 66768202

GI number: 66768202

Start: 2275170

End: 2277083

Strand: Direct

Name: cocE [H]

Synonym: XC_1881

Alternate gene names: 66768202

Gene position: 2275170-2277083 (Clockwise)

Preceding gene: 66768201

Following gene: 66768207

Centisome position: 44.19

GC content: 65.46

Gene sequence:

>1914_bases
ATGCGTCGTCTTGCCGCCTGCCTGCTCGCTACCGCCGTTGCCGCCGCCACCAGCGCGGCGCTGGCGCAGACCTCGCCGAT
GACCCCGGACATCACCGGCAAGCCGTTCGTGGCAGGCGACGCCGCCAACGACTACGTCAAGCGCGAGGTGATGATCCCCA
TGCGCGACGGGGTCAAGCTGCATACGGTGATCGTGTTGCCCAAGGGCGCGCGCAATGCGCCAATCGTACTCACGCGCACG
CCGTACGACGCCAGCGGCCGCACCGAGCGTCTGGCCTCGCCGCATATGAAGGACCTGTTGTCTGCAGGCGATGACGTGTT
CGTGGAAGGCGGTTATATCCGCGTGTTCCAGGATGTGCGCGGCAAGTACGGCTCGGAAGGCGATTACGTGATGACCCGGC
CGTTGCGCGGGCCGCTTAATCCCAGCGAGGTCGACCATGCCACCGATGCGTGGGACACCATCGATTGGCTGGTCAAGAAC
GTCAAGGAATCCAACGGCAAGGTCGGCATGATCGGCTCGTCCTACGAAGGTTTCACCGTGGTGATGGCGCTGACCAATCC
GCATCCCGCATTGAAGGTGGCCGCGCCGGAGAGCCCGATGATCGATGGCTGGATGGGCGACGACTGGTTCAATTACGGTG
CGTTCCGCCAGGTCAATTTCGACTACTTCACCGGCCAGCTCAGCAAGCGCGGCAAGGGCGCCGGCATCCCGCGTCAGGGG
CACGACGATTACAGCAATTTCCTGCAGGCCGGCTCGGCCGGCGACTTCGCCAAGGCCGCCGGCCTGGAGCAACTGCCGTG
GTGGCACAAGCTCACCGAACACGCCGCCTACGACAGTTTCTGGCAGGAGCAGGCGCTGGACAAGGTGATGGCACGCACGC
CGTTGAAAGTGCCGACCATGTGGTTGCAGGGCCTGTGGGACCAGGAGGATATGTGGGGCGCCATCCACAGTTACGCGGCG
ATGGAGCCGCGCGACAAGAGCAACAAGCTCAACTATCTGGTGATGGGGCCGTGGCGGCACAGCCAGGTCAATAGCGACGC
CAGTTCACTGGGTGCACTGAATTTCGACGGCGATACCGCACGCCAGTTCCGTCGCGATGTGCTGCGCCCGTTCTTCGACC
AGTACCTGGTCGATGGCGCGCCGAAAGCCGCCACGCCGCCCGTGTTCATCTACAACACCGGCGAGAACCATTGGGACCGC
CTGCAGGCCTGGCCACGCAGCTGCGACAAGGGCTGCGCCGCCAAGAGCAAGCCGCTGTATCTGCAGGCGGGCGGCAAGCT
GTCGTTCCAGGCGCCAACGGCTGCGCAACCGGCGTTCGAGGAATACGTGTCCGACCCGGCCAAGCCGGTGCCGTTCGTGC
CACGCCCGGTCGACTTCGGCGACCGCAGCATGTGGACCACCTGGCTGGTGCACGACCAGCGCTTCGTCGATGGCCGCCCG
GACGTCCTCACCTTCGTCACCGAGCCGCTGACCGCACCGCTGCAGATCGCCGGCGCGCCGGATGTGCATCTGCAGGCGTC
CACCAGCGGCAGCGACAGCGATTGGGTGGTCAAGCTGATCGATGTCTACCCGGACGAGATGGCGGCCGACCCGAAGATGG
GCGGCTACGAGCTGCCGGTGTCGATGGCGATCTTCCGCGGCCGCTACCGCGAAAGTTTCAGCACGCCCGCGCCGCTGGCA
GCCAACCAGCCGCTGGCATTCCAGTTCGGCCTGCCCACTGCCAATCACACCTTCCAGCCGGGCCACCGGGTGATGGTGCA
GGTGCAGTCCAGCCTGTTCCCGCTGTACGACCGCAACCCGCAGACCTACGTGCCCAATGTCTTCTTCGCCAAGCCCGGCG
ATTATCAGAAGGCGACCCAGCGCGTGTACGTGGCGCCGGGGCAGGGCAGCTACATCAGTCTGCCGGTGCGTTGA

Upstream 100 bases:

>100_bases
CCAGGCAGCCGGATCACCGCAACCACGACCTTTGACACTCCCCCCGGCGCCGCCGCGCTGCCTACAGTCGACGACTTCCC
CCCAGTTTCCGGAGTCGTCG

Downstream 100 bases:

>100_bases
CGCCACGGGCGCTGCGTGCCGGCGGCGCCCATACGTCTTCCAGCCACTGCGGGCGGCAGGCCACCCAGGCGGCCACCAGC
TGGATCAAGATGCAGGCGGC

Product: glutaryl-7-ACA acylase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MRRLAACLLATAVAAATSAALAQTSPMTPDITGKPFVAGDAANDYVKREVMIPMRDGVKLHTVIVLPKGARNAPIVLTRT
PYDASGRTERLASPHMKDLLSAGDDVFVEGGYIRVFQDVRGKYGSEGDYVMTRPLRGPLNPSEVDHATDAWDTIDWLVKN
VKESNGKVGMIGSSYEGFTVVMALTNPHPALKVAAPESPMIDGWMGDDWFNYGAFRQVNFDYFTGQLSKRGKGAGIPRQG
HDDYSNFLQAGSAGDFAKAAGLEQLPWWHKLTEHAAYDSFWQEQALDKVMARTPLKVPTMWLQGLWDQEDMWGAIHSYAA
MEPRDKSNKLNYLVMGPWRHSQVNSDASSLGALNFDGDTARQFRRDVLRPFFDQYLVDGAPKAATPPVFIYNTGENHWDR
LQAWPRSCDKGCAAKSKPLYLQAGGKLSFQAPTAAQPAFEEYVSDPAKPVPFVPRPVDFGDRSMWTTWLVHDQRFVDGRP
DVLTFVTEPLTAPLQIAGAPDVHLQASTSGSDSDWVVKLIDVYPDEMAADPKMGGYELPVSMAIFRGRYRESFSTPAPLA
ANQPLAFQFGLPTANHTFQPGHRVMVQVQSSLFPLYDRNPQTYVPNVFFAKPGDYQKATQRVYVAPGQGSYISLPVR

Sequences:

>Translated_637_residues
MRRLAACLLATAVAAATSAALAQTSPMTPDITGKPFVAGDAANDYVKREVMIPMRDGVKLHTVIVLPKGARNAPIVLTRT
PYDASGRTERLASPHMKDLLSAGDDVFVEGGYIRVFQDVRGKYGSEGDYVMTRPLRGPLNPSEVDHATDAWDTIDWLVKN
VKESNGKVGMIGSSYEGFTVVMALTNPHPALKVAAPESPMIDGWMGDDWFNYGAFRQVNFDYFTGQLSKRGKGAGIPRQG
HDDYSNFLQAGSAGDFAKAAGLEQLPWWHKLTEHAAYDSFWQEQALDKVMARTPLKVPTMWLQGLWDQEDMWGAIHSYAA
MEPRDKSNKLNYLVMGPWRHSQVNSDASSLGALNFDGDTARQFRRDVLRPFFDQYLVDGAPKAATPPVFIYNTGENHWDR
LQAWPRSCDKGCAAKSKPLYLQAGGKLSFQAPTAAQPAFEEYVSDPAKPVPFVPRPVDFGDRSMWTTWLVHDQRFVDGRP
DVLTFVTEPLTAPLQIAGAPDVHLQASTSGSDSDWVVKLIDVYPDEMAADPKMGGYELPVSMAIFRGRYRESFSTPAPLA
ANQPLAFQFGLPTANHTFQPGHRVMVQVQSSLFPLYDRNPQTYVPNVFFAKPGDYQKATQRVYVAPGQGSYISLPVR
>Mature_637_residues
MRRLAACLLATAVAAATSAALAQTSPMTPDITGKPFVAGDAANDYVKREVMIPMRDGVKLHTVIVLPKGARNAPIVLTRT
PYDASGRTERLASPHMKDLLSAGDDVFVEGGYIRVFQDVRGKYGSEGDYVMTRPLRGPLNPSEVDHATDAWDTIDWLVKN
VKESNGKVGMIGSSYEGFTVVMALTNPHPALKVAAPESPMIDGWMGDDWFNYGAFRQVNFDYFTGQLSKRGKGAGIPRQG
HDDYSNFLQAGSAGDFAKAAGLEQLPWWHKLTEHAAYDSFWQEQALDKVMARTPLKVPTMWLQGLWDQEDMWGAIHSYAA
MEPRDKSNKLNYLVMGPWRHSQVNSDASSLGALNFDGDTARQFRRDVLRPFFDQYLVDGAPKAATPPVFIYNTGENHWDR
LQAWPRSCDKGCAAKSKPLYLQAGGKLSFQAPTAAQPAFEEYVSDPAKPVPFVPRPVDFGDRSMWTTWLVHDQRFVDGRP
DVLTFVTEPLTAPLQIAGAPDVHLQASTSGSDSDWVVKLIDVYPDEMAADPKMGGYELPVSMAIFRGRYRESFSTPAPLA
ANQPLAFQFGLPTANHTFQPGHRVMVQVQSSLFPLYDRNPQTYVPNVFFAKPGDYQKATQRVYVAPGQGSYISLPVR

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 70467; Mature: 70467

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00306 CASEIN_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLAACLLATAVAAATSAALAQTSPMTPDITGKPFVAGDAANDYVKREVMIPMRDGVKL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHEEEEEECCCCCEE
HTVIVLPKGARNAPIVLTRTPYDASGRTERLASPHMKDLLSAGDDVFVEGGYIRVFQDVR
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCHHHHHHHCCCCEEEECCEEEEEHHHH
GKYGSEGDYVMTRPLRGPLNPSEVDHATDAWDTIDWLVKNVKESNGKVGMIGSSYEGFTV
CCCCCCCCEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
VMALTNPHPALKVAAPESPMIDGWMGDDWFNYGAFRQVNFDYFTGQLSKRGKGAGIPRQG
EEEEECCCCCEEEECCCCCCCCCCCCCCHHCCCCEEEECCHHEECHHHCCCCCCCCCCCC
HDDYSNFLQAGSAGDFAKAAGLEQLPWWHKLTEHAAYDSFWQEQALDKVMARTPLKVPTM
CHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WLQGLWDQEDMWGAIHSYAAMEPRDKSNKLNYLVMGPWRHSQVNSDASSLGALNFDGDTA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCEECCCCHHH
RQFRRDVLRPFFDQYLVDGAPKAATPPVFIYNTGENHWDRLQAWPRSCDKGCAAKSKPLY
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEE
LQAGGKLSFQAPTAAQPAFEEYVSDPAKPVPFVPRPVDFGDRSMWTTWLVHDQRFVDGRP
EEECCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCC
DVLTFVTEPLTAPLQIAGAPDVHLQASTSGSDSDWVVKLIDVYPDEMAADPKMGGYELPV
CEEEEECCCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCHHHCCCCCCCCEECCH
SMAIFRGRYRESFSTPAPLAANQPLAFQFGLPTANHTFQPGHRVMVQVQSSLFPLYDRNP
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCCCCCC
QTYVPNVFFAKPGDYQKATQRVYVAPGQGSYISLPVR
CCCCCEEEEECCCCHHHHCCEEEEECCCCCEEEECCC
>Mature Secondary Structure
MRRLAACLLATAVAAATSAALAQTSPMTPDITGKPFVAGDAANDYVKREVMIPMRDGVKL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHEEEEEECCCCCEE
HTVIVLPKGARNAPIVLTRTPYDASGRTERLASPHMKDLLSAGDDVFVEGGYIRVFQDVR
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCCHHHHHHHCCCCEEEECCEEEEEHHHH
GKYGSEGDYVMTRPLRGPLNPSEVDHATDAWDTIDWLVKNVKESNGKVGMIGSSYEGFTV
CCCCCCCCEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
VMALTNPHPALKVAAPESPMIDGWMGDDWFNYGAFRQVNFDYFTGQLSKRGKGAGIPRQG
EEEEECCCCCEEEECCCCCCCCCCCCCCHHCCCCEEEECCHHEECHHHCCCCCCCCCCCC
HDDYSNFLQAGSAGDFAKAAGLEQLPWWHKLTEHAAYDSFWQEQALDKVMARTPLKVPTM
CHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WLQGLWDQEDMWGAIHSYAAMEPRDKSNKLNYLVMGPWRHSQVNSDASSLGALNFDGDTA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCEECCCCHHH
RQFRRDVLRPFFDQYLVDGAPKAATPPVFIYNTGENHWDRLQAWPRSCDKGCAAKSKPLY
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEE
LQAGGKLSFQAPTAAQPAFEEYVSDPAKPVPFVPRPVDFGDRSMWTTWLVHDQRFVDGRP
EEECCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCC
DVLTFVTEPLTAPLQIAGAPDVHLQASTSGSDSDWVVKLIDVYPDEMAADPKMGGYELPV
CEEEEECCCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEECCCHHHCCCCCCCCEECCH
SMAIFRGRYRESFSTPAPLAANQPLAFQFGLPTANHTFQPGHRVMVQVQSSLFPLYDRNP
HHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCCCCCC
QTYVPNVFFAKPGDYQKATQRVYVAPGQGSYISLPVR
CCCCCEEEEECCCCHHHHCCEEEEECCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]