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The map label for this gene is upp [H]

Identifier: 66768051

GI number: 66768051

Start: 2088613

End: 2089245

Strand: Reverse

Name: upp [H]

Synonym: XC_1728

Alternate gene names: 66768051

Gene position: 2089245-2088613 (Counterclockwise)

Preceding gene: 66768056

Following gene: 66768044

Centisome position: 40.58

GC content: 66.19

Gene sequence:

>633_bases
ATGAAAATCGTCGAAGTCCGTCACCCCCTGGTCCAGCACAAGATCGGCCTGCTGCGTGACGCAGCGTTGAGCACCAAGGG
CTTCCGCGAACTGGTGACCGAGCTGGGCACCCTGCTGGCCTACGAGGCCACGGCCAATCTGGACACCGAATCGCACGTGC
AGCCGGGCTGGGCCGGGCCGGTGGAAGTGCAACGCATCGCCGGCGCCAAGATCACCCTGGTACCAATCCTGCGCGCCGGC
TTGGGGATGTTGCCGGGCGTGCTGGCACTGATTCCCGCCGCGCGCGTCAGCGTGGTCGGCCTGCAGCGCGATGAAGAAAC
CCTGCAACCGGTGCCGTATTTCGAGCGCCTCACCGGCCGCCTGGAAGAACGCGATGCGCTGATCCTGGACCCGATGCTGG
CCACCGGCGGCACGCTGATCGCCACCATCGACATGCTCAAGCGCGCTGGCGCACGGCGCATCAAGGGCATCTTCCTGGTC
GCCGCACCCGAAGGGCTGAAAGCGCTGGAAGCGGTACACCCGGACGTGGAAGTCTATACCGCCGCCATCGACGATCACCT
CAACGAAAAAGGCTACATCCTGCCCGGCCTGGGCGATGCCGGCGACCGGATCTTCGGCACGCGGGTGGAGTGA

Upstream 100 bases:

>100_bases
TTTCACCGACATGACATATGCGAGCACCATCACAGGCCCTGTGTGGCGACGCTGCGGCCGGCTGCGGCACACTGTGGGCC
TCTCCCGCATGCTGCCGCCC

Downstream 100 bases:

>100_bases
GCTTTCCAGCTGAAGTGAGTTTCCCGGCTGAGATGAGCGTCCCAAGCGTCCAGATCAAGAACCGACGCGCGCTGCACTAT
CCGACCGCGCTGCAACCGCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHVQPGWAGPVEVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNEKGYILPGLGDAGDRIFGTRVE

Sequences:

>Translated_210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHVQPGWAGPVEVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNEKGYILPGLGDAGDRIFGTRVE
>Mature_210_residues
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHVQPGWAGPVEVQRIAGAKITLVPILRAG
LGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGRLEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLV
AAPEGLKALEAVHPDVEVYTAAIDDHLNEKGYILPGLGDAGDRIFGTRVE

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=144, Percent_Identity=31.25, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI57863312, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=66.3461538461538, Blast_Score=293, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17539892, Length=145, Percent_Identity=28.9655172413793, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=145, Percent_Identity=28.9655172413793, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=39.8550724637681, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550449, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573516, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573514, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573512, Length=148, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22634; Mature: 22634

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHVQPGWAGP
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VEVQRIAGAKITLVPILRAGLGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGR
HHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHHH
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAVHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCHHHHHHHHCCCHHEEH
AAIDDHLNEKGYILPGLGDAGDRIFGTRVE
HHHHHCCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVRHPLVQHKIGLLRDAALSTKGFRELVTELGTLLAYEATANLDTESHVQPGWAGP
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VEVQRIAGAKITLVPILRAGLGMLPGVLALIPAARVSVVGLQRDEETLQPVPYFERLTGR
HHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHCCCCCHHHHHHHH
LEERDALILDPMLATGGTLIATIDMLKRAGARRIKGIFLVAAPEGLKALEAVHPDVEVYT
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHCCEEEEEECCCHHHHHHHHCCCHHEEH
AAIDDHLNEKGYILPGLGDAGDRIFGTRVE
HHHHHCCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]