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The map label for this gene is argD [H]

Identifier: 66768056

GI number: 66768056

Start: 2095603

End: 2097099

Strand: Reverse

Name: argD [H]

Synonym: XC_1733

Alternate gene names: 66768056

Gene position: 2097099-2095603 (Counterclockwise)

Preceding gene: 66768063

Following gene: 66768051

Centisome position: 40.73

GC content: 68.54

Gene sequence:

>1497_bases
ATGTCTGTCCTTGCCCCGCTCGCCCCGCTGCGTGCCCACGCCGGCCGCCGCCTGACCGCCGGCCTGGACGATGCCACCAT
CGAACGCCTGGCCACCGACCACCCCACCCTGCGCCAGGCCATCGAGGCCGCCGGCAGCGAATACGCGCTGGTGCAGGCCG
AGGTCGCCGACCTACTGGACCTGGACGAAGACGCACAGATCAGCGCGGTGCAGGACGGCTTCATCAATTTCTACGCCGAC
GATGCGGTAACTCCGTACGTGGCGCTGGCCGCGCGCGGCCCGTGGGTGATCACGCTCAAGGGCGCGGTGCTGTACGACGC
CGGCGGCTACGGCATGCTCGGTTTCGGCCATACGCCCGAGGCGGTGCTCGACGCCATGGCGCGCCCGCAGGTGATGGCCA
ACGTGATGACGCCCAGCCTGGCGCAGCGCAAGCTCGACCGCGCCCTGCGTGCGGAGATCGGCCACACCCGCGGCGGCTGC
CCGTTCGCGCGCTTCATGTGCCTCAACTCCGGCTCCGAAGCGGTGGGCCTGGCCGCGCGCATCGTCGACACCAACGCCAA
GCTGCACACCGATCCGGGTGCGCGCCACGCCGGCGCCACCATCAAGCGCCTGGTGGTCAAGGGCAGCTTCCACGGCCGCA
CCGATCGCCCGGGGCTGTATTCCGATTCCAGCCGCAAGACCTACAGCAAGTACCTGGCCAGCTACCGCGACGAAGACTCG
GTGATTGCGATTGCGCCGTATGACATCGCCGCCCTGCAGCGTGCCTTCGATGAGGCTGCGCGCAACCACTGGTTCATCGA
GGCGGTGTTCCTGGAGCCGGTGATGGGCGAAGGCGACCCGGGCCGTGCGCTGCCGGCGGAGTTCTACGCTGCCGCGCGCA
CGCTGACCCGCAACCACGGCAGCCTGCTGCTGGTGGATTCGATCCAGGCCGGCCTGCGTGCGCACGGCGTGCTGTCGGTG
GTGGATTACCCCGGTTTCGAACAGCTCGATCCGCCGGATCTGGAAACCTATTCCAAGGCGCTCAATGCCGCGCAATATCC
GCTCTCGGTGCTCGCGGTGACCGAGCAGGCCGCGCAGGTGTACCGCAAGGGCACCTACGGCAACACCATGACTACCAACC
CGCGCGCGCTGGATGTGGCTTGCGCCACCCTGGCGCTGTTCACCCCGCAGATCCGCGACAACATCCGCCTGCGCGGTGCA
CAGGCGCTGCGCAAGCTGGAAGCGCTGCAGGCCGAGCTCGGCGGCCTGATCACCAAGGTGCAGGGCACCGGCTTGCTGTT
CTCCTGCGAACTGGCACCGCAGTACAAGTGCTACGGTGCCGGCTCTACCGAGGAGTGGCTGCGCCACCACGGCGTCAACG
TGATCCACGGCGGCGAGAATTCGCTGCGCTTCACCCCGCACTTCGGCATGGACGAAGCCGAACTCGACCTGCTGGTGGGC
CTGATCGCCAAAGCGCTCAAGGAAGGCCCGCGTCAGGCGCAGGCCGAGGCGGCTTGA

Upstream 100 bases:

>100_bases
AATCGACGAAAATACCTCAATTCCTGCCCGGATCGGCGCTGCCAAACGACGATCCACTGCCGTTAATGTGACGGGAACGC
CACCGCTTCAGGAGATGCGC

Downstream 100 bases:

>100_bases
GGGCTGGTGAATAGGTTGAGTGCTGGCGAGGTGACTTGCCGCCAGCACGGTGCAACTGGTGCTGGCGGCGTCTGACACGC
GCCGGGCAGTGGATCTGGCA

Product: L-lysine 6-aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSVLAPLAPLRAHAGRRLTAGLDDATIERLATDHPTLRQAIEAAGSEYALVQAEVADLLDLDEDAQISAVQDGFINFYAD
DAVTPYVALAARGPWVITLKGAVLYDAGGYGMLGFGHTPEAVLDAMARPQVMANVMTPSLAQRKLDRALRAEIGHTRGGC
PFARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYSKYLASYRDEDS
VIAIAPYDIAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARTLTRNHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEQAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQIRDNIRLRGA
QALRKLEALQAELGGLITKVQGTGLLFSCELAPQYKCYGAGSTEEWLRHHGVNVIHGGENSLRFTPHFGMDEAELDLLVG
LIAKALKEGPRQAQAEAA

Sequences:

>Translated_498_residues
MSVLAPLAPLRAHAGRRLTAGLDDATIERLATDHPTLRQAIEAAGSEYALVQAEVADLLDLDEDAQISAVQDGFINFYAD
DAVTPYVALAARGPWVITLKGAVLYDAGGYGMLGFGHTPEAVLDAMARPQVMANVMTPSLAQRKLDRALRAEIGHTRGGC
PFARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYSKYLASYRDEDS
VIAIAPYDIAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARTLTRNHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEQAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQIRDNIRLRGA
QALRKLEALQAELGGLITKVQGTGLLFSCELAPQYKCYGAGSTEEWLRHHGVNVIHGGENSLRFTPHFGMDEAELDLLVG
LIAKALKEGPRQAQAEAA
>Mature_497_residues
SVLAPLAPLRAHAGRRLTAGLDDATIERLATDHPTLRQAIEAAGSEYALVQAEVADLLDLDEDAQISAVQDGFINFYADD
AVTPYVALAARGPWVITLKGAVLYDAGGYGMLGFGHTPEAVLDAMARPQVMANVMTPSLAQRKLDRALRAEIGHTRGGCP
FARFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYSKYLASYRDEDSV
IAIAPYDIAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARTLTRNHGSLLLVDSIQAGLRAHGVLSVV
DYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEQAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQIRDNIRLRGAQ
ALRKLEALQAELGGLITKVQGTGLLFSCELAPQYKCYGAGSTEEWLRHHGVNVIHGGENSLRFTPHFGMDEAELDLLVGL
IAKALKEGPRQAQAEAA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=25.1870324189526, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI284507298, Length=336, Percent_Identity=26.4880952380952, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=27.4752475247525, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788044, Length=317, Percent_Identity=31.2302839116719, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=25.3164556962025, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=244, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=26.0975609756098, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357415, Length=332, Percent_Identity=23.7951807228916, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 53605; Mature: 53474

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAPLAPLRAHAGRRLTAGLDDATIERLATDHPTLRQAIEAAGSEYALVQAEVADLLD
CCCCCCCHHHHHHCCCEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHC
LDEDAQISAVQDGFINFYADDAVTPYVALAARGPWVITLKGAVLYDAGGYGMLGFGHTPE
CCCCCCHHHHHCCCEEEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCEECCCCCCHH
AVLDAMARPQVMANVMTPSLAQRKLDRALRAEIGHTRGGCPFARFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYSKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDIAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARTLTRNHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEQAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQIRDNIRLRGAQALRKLEALQAELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCEECHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELAPQYKCYGAGSTEEWLRHHGVNVIHGGENSLRFTPHFGMDEAELDLLVG
ECCCEEEEEECCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHH
LIAKALKEGPRQAQAEAA
HHHHHHHCCCCHHCCCCC
>Mature Secondary Structure 
SVLAPLAPLRAHAGRRLTAGLDDATIERLATDHPTLRQAIEAAGSEYALVQAEVADLLD
CCCCCCHHHHHHCCCEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHC
LDEDAQISAVQDGFINFYADDAVTPYVALAARGPWVITLKGAVLYDAGGYGMLGFGHTPE
CCCCCCHHHHHCCCEEEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCEECCCCCCHH
AVLDAMARPQVMANVMTPSLAQRKLDRALRAEIGHTRGGCPFARFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYSKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDIAALQRAFDEAARNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARTLTRNHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVTEQAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQIRDNIRLRGAQALRKLEALQAELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCEECHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELAPQYKCYGAGSTEEWLRHHGVNVIHGGENSLRFTPHFGMDEAELDLLVG
ECCCEEEEEECCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHH
LIAKALKEGPRQAQAEAA
HHHHHHHCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]