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The map label for this gene is gyaR [H]

Identifier: 66767892

GI number: 66767892

Start: 1885876

End: 1886934

Strand: Direct

Name: gyaR [H]

Synonym: XC_1568

Alternate gene names: 66767892

Gene position: 1885876-1886934 (Clockwise)

Preceding gene: 66767891

Following gene: 66767893

Centisome position: 36.63

GC content: 68.56

Gene sequence:

>1059_bases
ATGTCTGACACCGCGCGCCCCAAGGTCTGGGTCAGCCAGCCGTTGTTCGACGATGTGGTCGAACAGCTGGGCGCGCATTT
CGAACTGGTCACCACCGCGCAGGTCACGGCGTATTCGTCCGCCGACCTCGCCGCGCGGCTCGCGCCGCTGGATGGCGCGC
TGGTCACGCTCAACGAGCGCATCGGTGCAGCGGAAATCGCCGCAGCACCGCAGCTGCGTGCCATCGCCAATGTCGGGGTG
GGTTACAACAACCTCGACATCGATGCGCTGAGCGCGGCGGGCATCCTGGCCAGCAACACGCCGGATGTGTTGAGCGAAAC
CACCGCCGACCTGGGGTTTGCCCTGCTGATGGCCACCGCACGCCGCGTCACCGAGGCCGAACGCTGGCTACGTGACGGGC
AGTGGGGGCAGTGGTCGTTCAAGACCATGCTCGGCGCCGATATCCATGGCAGCACGCTGGGCATCCTGGGCATGGGCCGG
ATCGGGCAGGGCATCGCCCGGCGTGGCGCGCATGGCTTCGGCATGCGCGTGCTCTATCACAACCGCAGCCAGCTGCCGGC
CGAGACCGAACAGGCGGTGGGTGCGCAGTATGTCGGCCTCGACACCTTGCTGGCGCAGTCCGATCACCTGGTACTGGTGC
TGCCCTACACCCAGGCCTCGCACCACATCATCGATGCCGCCGCGCTGGCGAAGATGCGGCCCACCGCCACGCTGGTGAAC
ATCGCGCGCGGCGGGATCGTCGATGAGATCGCGCTGGCCGATGCGTTGGCCAATGGCCGCCTCGCCGGTGCCGGTCTCGA
TGTCTACGAGGGCGAGCCCCGGGTGCGCCCGGAACTGCTGGCGCAGCACAACGTGGTGCTCACCCCGCATATCGGCAGTG
CCAGCCTGGCCACGCGCCGCGCCATGGTGCAGCTGGCGGTGGACAACCTGATCGCTGCGCTGGGCGTGGGTGCCAACGCT
GGGCATCCGCCGAGCGCACTCAACGCCGATGCGGTGGCGGCTGCCAAACGCGGTGGCGCGACCGTGGGCGCGACCAAAAC
CGCTGCGACCAAACGATAG

Upstream 100 bases:

>100_bases
GAGGCCATGATGGCGCTGGTATTGATGGACCAGGCCTTGCGCCATCGCGCCCAATGCGGCGACGTGGGCGAGGTGTCGCC
GCTGATTCCCGGTCAGGCCG

Downstream 100 bases:

>100_bases
GGAACCTCCGCGGCCAGCTTTGGAGGTTCCCCGAACCCAGCGCGCAGTGCTCCCTTTCTTTCCCCTTTCGATAAAGACAT
TCTCATGAGCAACGAAACCC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSDTARPKVWVSQPLFDDVVEQLGAHFELVTTAQVTAYSSADLAARLAPLDGALVTLNERIGAAEIAAAPQLRAIANVGV
GYNNLDIDALSAAGILASNTPDVLSETTADLGFALLMATARRVTEAERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGR
IGQGIARRGAHGFGMRVLYHNRSQLPAETEQAVGAQYVGLDTLLAQSDHLVLVLPYTQASHHIIDAAALAKMRPTATLVN
IARGGIVDEIALADALANGRLAGAGLDVYEGEPRVRPELLAQHNVVLTPHIGSASLATRRAMVQLAVDNLIAALGVGANA
GHPPSALNADAVAAAKRGGATVGATKTAATKR

Sequences:

>Translated_352_residues
MSDTARPKVWVSQPLFDDVVEQLGAHFELVTTAQVTAYSSADLAARLAPLDGALVTLNERIGAAEIAAAPQLRAIANVGV
GYNNLDIDALSAAGILASNTPDVLSETTADLGFALLMATARRVTEAERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGR
IGQGIARRGAHGFGMRVLYHNRSQLPAETEQAVGAQYVGLDTLLAQSDHLVLVLPYTQASHHIIDAAALAKMRPTATLVN
IARGGIVDEIALADALANGRLAGAGLDVYEGEPRVRPELLAQHNVVLTPHIGSASLATRRAMVQLAVDNLIAALGVGANA
GHPPSALNADAVAAAKRGGATVGATKTAATKR
>Mature_351_residues
SDTARPKVWVSQPLFDDVVEQLGAHFELVTTAQVTAYSSADLAARLAPLDGALVTLNERIGAAEIAAAPQLRAIANVGVG
YNNLDIDALSAAGILASNTPDVLSETTADLGFALLMATARRVTEAERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRI
GQGIARRGAHGFGMRVLYHNRSQLPAETEQAVGAQYVGLDTLLAQSDHLVLVLPYTQASHHIIDAAALAKMRPTATLVNI
ARGGIVDEIALADALANGRLAGAGLDVYEGEPRVRPELLAQHNVVLTPHIGSASLATRRAMVQLAVDNLIAALGVGANAG
HPPSALNADAVAAAKRGGATVGATKTAATKR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=41.2, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI23308577, Length=271, Percent_Identity=33.9483394833948, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=38.0952380952381, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=38.0952380952381, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=35.8108108108108, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=35.8108108108108, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=39.6694214876033, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=43.3021806853583, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=30.0395256916996, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=32.4110671936759, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87081824, Length=168, Percent_Identity=33.9285714285714, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=326, Percent_Identity=31.2883435582822, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=240, Percent_Identity=28.3333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=38.9121338912134, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6320925, Length=319, Percent_Identity=28.5266457680251, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=292, Percent_Identity=29.1095890410959, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=157, Percent_Identity=35.031847133758, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=272, Percent_Identity=25.3676470588235, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=271, Percent_Identity=24.7232472324723, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=38.3870967741935, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=37.1875, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=37.1875, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=40.1515151515151, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19921140, Length=331, Percent_Identity=32.02416918429, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=32.9317269076305, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646446, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646448, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646452, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646450, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=34.0823970037453, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36624; Mature: 36493

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTARPKVWVSQPLFDDVVEQLGAHFELVTTAQVTAYSSADLAARLAPLDGALVTLNER
CCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHCCCCCEEEEECCC
IGAAEIAAAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLSETTADLGFALLMATA
CCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHH
RRVTEAERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIARRGAHGFGMRVLYH
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEE
NRSQLPAETEQAVGAQYVGLDTLLAQSDHLVLVLPYTQASHHIIDAAALAKMRPTATLVN
CCCCCCCHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHH
IARGGIVDEIALADALANGRLAGAGLDVYEGEPRVRPELLAQHNVVLTPHIGSASLATRR
HHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCHHHHHCCCEEEECCCCCHHHHHHH
AMVQLAVDNLIAALGVGANAGHPPSALNADAVAAAKRGGATVGATKTAATKR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDTARPKVWVSQPLFDDVVEQLGAHFELVTTAQVTAYSSADLAARLAPLDGALVTLNER
CCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHCCCCCEEEEECCC
IGAAEIAAAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLSETTADLGFALLMATA
CCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHH
RRVTEAERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIARRGAHGFGMRVLYH
HHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEE
NRSQLPAETEQAVGAQYVGLDTLLAQSDHLVLVLPYTQASHHIIDAAALAKMRPTATLVN
CCCCCCCHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHH
IARGGIVDEIALADALANGRLAGAGLDVYEGEPRVRPELLAQHNVVLTPHIGSASLATRR
HHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCHHHHHCCCEEEECCCCCHHHHHHH
AMVQLAVDNLIAALGVGANAGHPPSALNADAVAAAKRGGATVGATKTAATKR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA