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The map label for this gene is proC [H]

Identifier: 66767683

GI number: 66767683

Start: 1640591

End: 1641523

Strand: Reverse

Name: proC [H]

Synonym: XC_1356

Alternate gene names: 66767683

Gene position: 1641523-1640591 (Counterclockwise)

Preceding gene: 66767684

Following gene: 66767682

Centisome position: 31.88

GC content: 70.42

Gene sequence:

>933_bases
TTGGCCAGCGCAACGCGCCACCGGCCGCCTGACACGTCGGCCGTTTCCTTCCTCCTTCTTGATGGTGCTGCAATGACCCA
GCCTTCCTCCTCCACAGCTGTGGCTGCACACGGCGATGTTCCGGTGGTTGCCTTTGTCGGTGGCGGCAACATGGCGCGCA
GCCTGATCGCCGGGCTGCTGCGCCAGGGCGCGCCGGCCAGCGCCATCCGCGTCGCCGAGCCGGTCGCCGAACTGCGTCAG
GCGCTGTCCGCTGACTTCGGCGTGCAAGTGTTCGACGACGCGCGCAGCGCCGTGGAGGGCGCCGCACTCTGGGTACTGGC
GGTCAAGCCGCAGGTCATGTCCACCGTGTGCACGCAGCTGGCCGATCTCGCGCAGCAACAGCATCCGCTGCTGCTGTCGA
TCGCCGCGGGCATCACCGCAACGCAACTGGAGCGCTGGTGCGGCGGCACGGCCGCCGTGGTGCGCGCCATGCCCAACACG
CCGGCCCTGCTCGGCGCCGGCGTGACCGGCCTGTACGCCAATGCACGCGTCAGCGCGGCGCAGCGCACACAGGCAACCCG
GCTGCTGGAAAGCGCTGGCGTCACCGTCTGGCTCGACGACGAGGCACAGATGGATGCGGTCACCGCGGTGTCCGGCAGCG
GCCCGGCCTATGTCTTTCTGCTGGCCGAAGCGATGGAGGCCGCGGCGCGCGCGCAAGGCCTGCCCGCCGAGACCGCCCGC
ACGCTGGTGCTGCATACCCTGCTCGGCGCTGCACGCATGCTGACCGAATCCGGCGAAGCACCGGAGGTATTGCGCCGGCG
CGTGACCTCCCCCAACGGCACCACGCAGGCCGCGATCGAGGAATTCCAGGCCGGCGGTTTCGAAGCGTTGACCGCCACCG
CGATTGCCGCGGCGACCGAACGCGGCCGCAGTTTGTCGGCAGCGAACGACTGA

Upstream 100 bases:

>100_bases
CAGTATCCGCAGGCAGATACCTTGTCGATGGGCATGAGCGCGGATTTCGCCGATGCCATTGCGGCCGGCGCCACCATGGT
GCGCGTGGGCACGGCGCTAT

Downstream 100 bases:

>100_bases
TCCGCGGGAGCGATGCGTCGTCGCTGGCTGGCTGGATCGCTCGCTTGCCTGGAAACGCGCTATTCGGCGCATCGCTGTCC
GAATGCGGAATGATGCGAGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLLRQGAPASAIRVAEPVAELRQ
ALSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQLADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNT
PALLGAGVTGLYANARVSAAQRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETAR
TLVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATERGRSLSAAND

Sequences:

>Translated_310_residues
MASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLLRQGAPASAIRVAEPVAELRQ
ALSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQLADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNT
PALLGAGVTGLYANARVSAAQRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETAR
TLVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATERGRSLSAAND
>Mature_309_residues
ASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLLRQGAPASAIRVAEPVAELRQA
LSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQLADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNTP
ALLGAGVTGLYANARVSAAQRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETART
LVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATERGRSLSAAND

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.0606060606061, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI24797097, Length=281, Percent_Identity=31.6725978647687, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI21361454, Length=279, Percent_Identity=31.5412186379928, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI24797095, Length=281, Percent_Identity=31.6725978647687, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=34.5864661654135, Blast_Score=144, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=266, Percent_Identity=33.0827067669173, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=30.4964539007092, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=269, Percent_Identity=30.8550185873606, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=36.4661654135338, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24648116, Length=272, Percent_Identity=32.7205882352941, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=40, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 31707; Mature: 31576

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLL
CCCCCCCCCCCHHHHEEHEECCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHH
RQGAPASAIRVAEPVAELRQALSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQL
HCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHEEEEEEECHHHHHHHHHHH
ADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNTPALLGAGVTGLYANARVSAA
HHHHHHCCCEEEEHHCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHCCCHHHHHCCHHHHH
QRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETAR
HHHHHHHHHHHCCCEEEECCCCCHHHEEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHH
TLVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATE
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
RGRSLSAAND
CCCCCCCCCC
>Mature Secondary Structure 
ASATRHRPPDTSAVSFLLLDGAAMTQPSSSTAVAAHGDVPVVAFVGGGNMARSLIAGLL
CCCCCCCCCCHHHHEEHEECCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHH
RQGAPASAIRVAEPVAELRQALSADFGVQVFDDARSAVEGAALWVLAVKPQVMSTVCTQL
HCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHEEEEEEECHHHHHHHHHHH
ADLAQQQHPLLLSIAAGITATQLERWCGGTAAVVRAMPNTPALLGAGVTGLYANARVSAA
HHHHHHCCCEEEEHHCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHCCCHHHHHCCHHHHH
QRTQATRLLESAGVTVWLDDEAQMDAVTAVSGSGPAYVFLLAEAMEAAARAQGLPAETAR
HHHHHHHHHHHCCCEEEECCCCCHHHEEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHH
TLVLHTLLGAARMLTESGEAPEVLRRRVTSPNGTTQAAIEEFQAGGFEALTATAIAAATE
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
RGRSLSAAND
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]