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The map label for this gene is nuoH [H]

Identifier: 162017103

GI number: 162017103

Start: 1915581

End: 1916672

Strand: Direct

Name: nuoH [H]

Synonym: XC_1596

Alternate gene names: 162017103

Gene position: 1915581-1916672 (Clockwise)

Preceding gene: 66767919

Following gene: 66767921

Centisome position: 37.21

GC content: 60.81

Gene sequence:

>1092_bases
ATGAACGAGTTGCTGTTGAACGTGGTCGACCCCCTGCACCAGTGGTTCCTCGGACTGGGCGATGGCGGCGTGTTGCTGTG
GACCGTGCTGAAGATCCTGCTGATCGCCGTGCCGGTGATTGTGACGGTGGCCTTCTACGTGGTCTGGGAGCGCAAGCTGA
TCGGCTGGATGCATGTGCGCCACGGGCCAATGTACGTGGGCATGGGCATCTTCCAGGCCTTCGCCGACGTCTTCAAATTG
CTGTTCAAGGAAATCCTGCAGCCCAGCAGCTCGCACAAGGCGATGTTCATCATCGCGCCATTGCTCACCCTGGCGCCGGC
GTTTGCGGCCTGGTCGGTGGTGCCGTTCGATGCGAAGCTGGTGTTGTCCAATGCCAACGTGGGTCTGCTGTACCTGCTGG
CGATGACCTCGCTGGGCGTCTACGGCATCATCCTGGCCGGCTGGGCGTCCAACTCCAAGTACGCGTTCCTGGGTGCGATG
CGCTCAGCCGCGCAGGTGGTCAGCTACGAAATTGCGATGGGCTTTGCACTGGTCGGCGTGATGATCGCCTCGGGCAGCGT
CAACCTCAGCCAGATCGTGTTTGCGCAGGCGGGTAGCTCCGGCTTCTTCGACTGGTTCCTGATTCCGCTGTTCCCGTTGT
TCATCGTGTACTGGGTCTCCGGCGTCGCCGAGACCAACCGCGCGCCGTTCGACGTAGTGGAAGGTGAATCGGAAATCGTC
GCCGGCCACATGGTGGAGTACTCGGGCGGCGCGTTTGCGCTGTTCTTCCTGGCCGAATACGCCAACATGATCCTGGTCAG
CTTCCTGATCTCGATCTTCTTCCTCGGTGGCTGGCTGAGCCCGATCCAGGGCTGGGTCACGGCGGATATCTCGCCGTGGG
TCAATTGGCTGTGGACCGGTGGCTGGCCGTGGCTGCTGATGAAGGTGTTCTTCTTTGCGAGTGCCTACATCTGGTTCCGC
GCAAGCTTCCCGCGTTACCGCTATGACCAGATCATGCGTCTGGGCTGGAAGGTGTTCATTCCGCTCACGATCGTGTGGAT
CGCGGTGACGGCATTGATGGTGTTTTACGGCGTGATCCAGAAGGGCGTGTAA

Upstream 100 bases:

>100_bases
TGGTGCTGGACAAGCGCGTCGCACCGGGCACGGTGTGGATCGAATCCGGCCATGGCGCAACCGCGCCGTTGGGTGCCGGT
CGGGTAACGGTGGTGGCTGC

Downstream 100 bases:

>100_bases
TTGATGAACAAGATCACCCATTACTTCAAGAGCCTGCTGCTGCTCGAACTGCTCGGAGGGCTGTGGCTGACGTTGAAATA
CACGTTCAAGCCCAAGTACA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADISPWVNWLWTGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV

Sequences:

>Translated_363_residues
MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADISPWVNWLWTGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV
>Mature_363_residues
MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVRHGPMYVGMGIFQAFADVFKL
LFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADISPWVNWLWTGGWPWLLMKVFFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQKGV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=304, Percent_Identity=41.7763157894737, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1788618, Length=331, Percent_Identity=38.9728096676737, Blast_Score=234, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 40454; Mature: 40454

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGIFQAFADVFKLLFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKL
CCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCEECCCCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
HHHCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADISPWVNWLWTG
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHEECC
GWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQ
CHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCC
>Mature Secondary Structure
MNELLLNVVDPLHQWFLGLGDGGVLLWTVLKILLIAVPVIVTVAFYVVWERKLIGWMHVR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGIFQAFADVFKLLFKEILQPSSSHKAMFIIAPLLTLAPAFAAWSVVPFDAKL
CCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCEECCCCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIASGSVNLSQIVFAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRAPFDVVEGESEIV
HHHCCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
AGHMVEYSGGAFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVTADISPWVNWLWTG
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHEECC
GWPWLLMKVFFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFYGVIQ
CHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]