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The map label for this gene is nuoI

Identifier: 66767921

GI number: 66767921

Start: 1916673

End: 1917164

Strand: Direct

Name: nuoI

Synonym: XC_1597

Alternate gene names: 66767921

Gene position: 1916673-1917164 (Clockwise)

Preceding gene: 162017103

Following gene: 66767922

Centisome position: 37.23

GC content: 60.16

Gene sequence:

>492_bases
TTGATGAACAAGATCACCCATTACTTCAAGAGCCTGCTGCTGCTCGAACTGCTCGGAGGGCTGTGGCTGACGTTGAAATA
CACGTTCAAGCCCAAGTACACCGTGCTGTATCCGATGGAGAAGTTCCCGCAGTCGCCGCGCTTCCGTGGGTTGCACGCGC
TGCGTCGCTACCCCAATGGCGAAGAGCGCTGCATTGCCTGCAAGCTGTGCGAAGCGGTTTGCCCGGCACTGGCGATCACC
ATCGACTCGGCCAAGCGCGAGGACGGCACCCGTCGCACCACGCGCTACGACATCGACCTGTTCAAGTGCATCTTCTGCGG
CTTCTGCGAAGAAAGCTGCCCGGTGGACTCGATCGTCGAAACGCACATCCTCGAGTACCACTTCGAGAAGCGTGGCGAGA
ATATTGTCAACAAGCCGCAGCTGCTGGCGATCGGAGACCGGCTTGAAGCCGAGATCGCCGAGCGTCGCGCTGCCGATGCC
GCCTTCCGTTGA

Upstream 100 bases:

>100_bases
CATGCGTCTGGGCTGGAAGGTGTTCATTCCGCTCACGATCGTGTGGATCGCGGTGACGGCATTGATGGTGTTTTACGGCG
TGATCCAGAAGGGCGTGTAA

Downstream 100 bases:

>100_bases
GGTCATGATGGACTGGGTCACTATTGCTTTCTACGCCTTCTCCGCCGTCGCGGTCGTCTCCGCCGGTGCGGTGATCAGCG
TGCGCAACCCGGTGTATGCC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVETHILEYHFEKRGENIVNKPQLLAIGDRLEAEIAERRAADA
AFR

Sequences:

>Translated_163_residues
MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVETHILEYHFEKRGENIVNKPQLLAIGDRLEAEIAERRAADA
AFR
>Mature_163_residues
MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVETHILEYHFEKRGENIVNKPQLLAIGDRLEAEIAERRAADA
AFR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=154, Percent_Identity=60.3896103896104, Blast_Score=191, Evalue=3e-49,
Organism=Escherichia coli, GI1788617, Length=141, Percent_Identity=37.5886524822695, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555194, Length=163, Percent_Identity=52.1472392638037, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17864306, Length=154, Percent_Identity=58.4415584415584, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_XANC8 (Q4UWB0)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242683.1
- HSSP:   P00198
- ProteinModelPortal:   Q4UWB0
- SMR:   Q4UWB0
- STRING:   Q4UWB0
- GeneID:   3380052
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1597
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   NKAADAP
- PhylomeDB:   Q4UWB0
- ProtClustDB:   PRK05888
- BioCyc:   XCAM314565:XC_1597-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18883; Mature: 18883

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2; PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNG
CCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEECHHHCCCCCCHHHHHHHHCCCCC
EERCIACKLCEAVCPALAITIDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVE
CHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHH
THILEYHFEKRGENIVNKPQLLAIGDRLEAEIAERRAADAAFR
HHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMNKITHYFKSLLLLELLGGLWLTLKYTFKPKYTVLYPMEKFPQSPRFRGLHALRRYPNG
CCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEECHHHCCCCCCHHHHHHHHCCCCC
EERCIACKLCEAVCPALAITIDSAKREDGTRRTTRYDIDLFKCIFCGFCEESCPVDSIVE
CHHHHHHHHHHHHHHHHEEEECCHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHH
THILEYHFEKRGENIVNKPQLLAIGDRLEAEIAERRAADAAFR
HHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA