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The map label for this gene is proY [H]

Identifier: 66048058

GI number: 66048058

Start: 5737809

End: 5739185

Strand: Direct

Name: proY [H]

Synonym: Psyr_4834

Alternate gene names: 66048058

Gene position: 5737809-5739185 (Clockwise)

Preceding gene: 66048057

Following gene: 66048059

Centisome position: 94.16

GC content: 62.45

Gene sequence:

>1377_bases
ATGACGTCACAAGATGGTTTGAAACGCGGGTTATCCGCCCGCCACATCCGCTTCATGGCCCTGGGCTCTGCCATCGGTAC
AGGGTTGTTCTACGGCTCGGCCTCGGCGATTCAACAGGCCGGGCCTGCCGTACTGCTGGCTTACCTGATCGGCGGCGCGG
CGGTGTACATGGTGATGCGCGCGCTCGGCGAAATGGCGGTCCACGACCCGGTGTCCGGTTCGTTCAGCCATTACGCCACG
CGCTACATGGGCCCGCTGGCCGGCTTCGTGCTCGGCTGGACCTATGCGTTCGAGATGATCATCGTCTGCCTCGCCGACGT
GACCGCATTCGGCATCTACATGGGCTTCTGGTTTCCGGAAGTGCCGCGCTGGATCTGGGTGCTGGGCATCGTCTTTCTGA
TCGGCGCGCTCAACCTGTGCAACGTGAAAGTCTTTGGTGAAACCGAGTTCTGGCTGTCGATCCTCAAGGTCAGCGCCATC
GTGGCGATGATCGTCGCAGGCTTCGGCATCATGATCTTCGGTATCGGCAGCTCGGCCAGCGGCAGCGAAATCGGCATCAG
CAACCTGTGGGCGCATGGCGGCTTCATGCCCAACGGTGTCACCGGCCTGATCGCCTCGTTCGCGGTGGTGATGTTTGCCT
TCGGCGGCATCGAAATCATCGGCATTACCGCAGGCGAAGCGAAGGACCCGCGACGCAGCCTGCCGCAAGCGATCAATGCC
GTGCCGCTGCGCATTCTGCTGTTCTACGTGCTGACTCTGTTCGTGCTGATGTGCATCTACCCGTGGCCGCAGATCGGCAC
GCAGGGCAGCCCGTTCGTGCAGATTTTCGACAACCTGGGTATCGCCTCGGCGGCGACCATCCTCAACATCGTGGTGATCT
CGGCGGCCGTCTCGGCGATCAACAGCGACATCTTCGGCGCAGGCCGCATGATGTATGGCCTGGCCCGTGAAGGTCAGGCG
CCCGCCAGTTTTGCCCGCGTGTCGCGCCATGGCGTGCCGTGGATGACCGTGCTGGTCATGGGCATCGCGCTGCTGGGCGG
CGTGCTGCTCAACTACCTGATCCCCAAGGACGTGTTCCTGCTGATCGCTTCGCTGGCCACCTTCGCCACCGTGTGGGTCT
GGCTGATGATTCTGCTGACGCAGGTCTCCATGCGCCGCTCGATGAGCCGCGAGGAAGCGGCACAGCTGAAATTCGCCGTG
CCGTTCTGGCCTTACGGGCCGGCGGCTGCCATTGCCTTCATGCTGTTCATCTTCGGCGTGCTGGGTTACTTCCCGGACAA
CCGTGCAGCCTTGATCGTCGGCGCAATCTGGATCGTGCTGCTGCTCATTGCCTACGCTGTGTGGGTCAAGCCCAAGGCGC
TCAACACCACTCATTGA

Upstream 100 bases:

>100_bases
CACCGCGAGCCTGGCAGGGCTCGCTTTGGTCATCGCTGCGGGAGGCCGGATGCAGGCGTTCTCGCGGCTTTTGCCATACC
TGTAATGAAATGGACCTGAA

Downstream 100 bases:

>100_bases
TCAACGAGGCCTCGAATGAAAACGCTCTGGAAAAACTGTCACATCGCAAGCATGGCGCACGGCAAATACTCGATCATCGA
GGATGCCGCCATCGTGACCT

Product: amino acid permease-associated region

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTSQDGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQQAGPAVLLAYLIGGAAVYMVMRALGEMAVHDPVSGSFSHYAT
RYMGPLAGFVLGWTYAFEMIIVCLADVTAFGIYMGFWFPEVPRWIWVLGIVFLIGALNLCNVKVFGETEFWLSILKVSAI
VAMIVAGFGIMIFGIGSSASGSEIGISNLWAHGGFMPNGVTGLIASFAVVMFAFGGIEIIGITAGEAKDPRRSLPQAINA
VPLRILLFYVLTLFVLMCIYPWPQIGTQGSPFVQIFDNLGIASAATILNIVVISAAVSAINSDIFGAGRMMYGLAREGQA
PASFARVSRHGVPWMTVLVMGIALLGGVLLNYLIPKDVFLLIASLATFATVWVWLMILLTQVSMRRSMSREEAAQLKFAV
PFWPYGPAAAIAFMLFIFGVLGYFPDNRAALIVGAIWIVLLLIAYAVWVKPKALNTTH

Sequences:

>Translated_458_residues
MTSQDGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQQAGPAVLLAYLIGGAAVYMVMRALGEMAVHDPVSGSFSHYAT
RYMGPLAGFVLGWTYAFEMIIVCLADVTAFGIYMGFWFPEVPRWIWVLGIVFLIGALNLCNVKVFGETEFWLSILKVSAI
VAMIVAGFGIMIFGIGSSASGSEIGISNLWAHGGFMPNGVTGLIASFAVVMFAFGGIEIIGITAGEAKDPRRSLPQAINA
VPLRILLFYVLTLFVLMCIYPWPQIGTQGSPFVQIFDNLGIASAATILNIVVISAAVSAINSDIFGAGRMMYGLAREGQA
PASFARVSRHGVPWMTVLVMGIALLGGVLLNYLIPKDVFLLIASLATFATVWVWLMILLTQVSMRRSMSREEAAQLKFAV
PFWPYGPAAAIAFMLFIFGVLGYFPDNRAALIVGAIWIVLLLIAYAVWVKPKALNTTH
>Mature_457_residues
TSQDGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQQAGPAVLLAYLIGGAAVYMVMRALGEMAVHDPVSGSFSHYATR
YMGPLAGFVLGWTYAFEMIIVCLADVTAFGIYMGFWFPEVPRWIWVLGIVFLIGALNLCNVKVFGETEFWLSILKVSAIV
AMIVAGFGIMIFGIGSSASGSEIGISNLWAHGGFMPNGVTGLIASFAVVMFAFGGIEIIGITAGEAKDPRRSLPQAINAV
PLRILLFYVLTLFVLMCIYPWPQIGTQGSPFVQIFDNLGIASAATILNIVVISAAVSAINSDIFGAGRMMYGLAREGQAP
ASFARVSRHGVPWMTVLVMGIALLGGVLLNYLIPKDVFLLIASLATFATVWVWLMILLTQVSMRRSMSREEAAQLKFAVP
FWPYGPAAAIAFMLFIFGVLGYFPDNRAALIVGAIWIVLLLIAYAVWVKPKALNTTH

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=361, Percent_Identity=27.7008310249307, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI181337167, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI258645169, Length=369, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI114326544, Length=434, Percent_Identity=22.1198156682028, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI114326550, Length=434, Percent_Identity=22.1198156682028, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI71999149, Length=301, Percent_Identity=22.5913621262458, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=445, Percent_Identity=62.9213483146067, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=45.2702702702703, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786302, Length=441, Percent_Identity=44.671201814059, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI48994972, Length=448, Percent_Identity=43.0803571428571, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1790653, Length=441, Percent_Identity=39.2290249433107, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI87081915, Length=404, Percent_Identity=37.6237623762376, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87081708, Length=452, Percent_Identity=38.2743362831858, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1789017, Length=425, Percent_Identity=36, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1788480, Length=434, Percent_Identity=36.6359447004608, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87081869, Length=240, Percent_Identity=25, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082023, Length=357, Percent_Identity=22.6890756302521, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI2367353, Length=355, Percent_Identity=24.2253521126761, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=421, Percent_Identity=24.2280285035629, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=420, Percent_Identity=26.9047619047619, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=343, Percent_Identity=22.7405247813411, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=472, Percent_Identity=33.0508474576271, Blast_Score=215, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6324990, Length=486, Percent_Identity=32.9218106995885, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320772, Length=467, Percent_Identity=31.2633832976445, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=467, Percent_Identity=30.406852248394, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=478, Percent_Identity=29.9163179916318, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=432, Percent_Identity=31.712962962963, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=27.4752475247525, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=412, Percent_Identity=27.9126213592233, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=435, Percent_Identity=26.8965517241379, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=419, Percent_Identity=29.3556085918854, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=26.4197530864197, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=423, Percent_Identity=27.6595744680851, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=28.1012658227848, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=25.8620689655172, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=401, Percent_Identity=24.9376558603491, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=28.1012658227848, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=457, Percent_Identity=26.2582056892779, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=502, Percent_Identity=24.5019920318725, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24667468, Length=360, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077963, Length=382, Percent_Identity=24.6073298429319, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49280; Mature: 49149

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQDGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQQAGPAVLLAYLIGGAAVYMVMR
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMAVHDPVSGSFSHYATRYMGPLAGFVLGWTYAFEMIIVCLADVTAFGIYMGFWFPE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPRWIWVLGIVFLIGALNLCNVKVFGETEFWLSILKVSAIVAMIVAGFGIMIFGIGSSAS
HHHHHHHHHHHHHHHCHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
GSEIGISNLWAHGGFMPNGVTGLIASFAVVMFAFGGIEIIGITAGEAKDPRRSLPQAINA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHH
VPLRILLFYVLTLFVLMCIYPWPQIGTQGSPFVQIFDNLGIASAATILNIVVISAAVSAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NSDIFGAGRMMYGLAREGQAPASFARVSRHGVPWMTVLVMGIALLGGVLLNYLIPKDVFL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIASLATFATVWVWLMILLTQVSMRRSMSREEAAQLKFAVPFWPYGPAAAIAFMLFIFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
LGYFPDNRAALIVGAIWIVLLLIAYAVWVKPKALNTTH
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSQDGLKRGLSARHIRFMALGSAIGTGLFYGSASAIQQAGPAVLLAYLIGGAAVYMVMR
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMAVHDPVSGSFSHYATRYMGPLAGFVLGWTYAFEMIIVCLADVTAFGIYMGFWFPE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPRWIWVLGIVFLIGALNLCNVKVFGETEFWLSILKVSAIVAMIVAGFGIMIFGIGSSAS
HHHHHHHHHHHHHHHCHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
GSEIGISNLWAHGGFMPNGVTGLIASFAVVMFAFGGIEIIGITAGEAKDPRRSLPQAINA
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHH
VPLRILLFYVLTLFVLMCIYPWPQIGTQGSPFVQIFDNLGIASAATILNIVVISAAVSAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NSDIFGAGRMMYGLAREGQAPASFARVSRHGVPWMTVLVMGIALLGGVLLNYLIPKDVFL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIASLATFATVWVWLMILLTQVSMRRSMSREEAAQLKFAVPFWPYGPAAAIAFMLFIFGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHH
LGYFPDNRAALIVGAIWIVLLLIAYAVWVKPKALNTTH
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]