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The map label for this gene is hutH [H]

Identifier: 66048057

GI number: 66048057

Start: 5736159

End: 5737706

Strand: Direct

Name: hutH [H]

Synonym: Psyr_4833

Alternate gene names: 66048057

Gene position: 5736159-5737706 (Clockwise)

Preceding gene: 66048056

Following gene: 66048058

Centisome position: 94.13

GC content: 63.37

Gene sequence:

>1548_bases
GTGACCACCTTATCTGCCAAGACGCTGAACCTGATCCCCAGCCAACTGACCCTGGCGCAACTGCGCGGCATTTATCTGCA
GCCGGTCAGCCTGACGCTGGACAGCAGCGCGAACCAGCAGATCGACGACAGCGTCGCCTGTGTCGAGCGCATTCTGGCCG
AGAACCGCACCGCCTACGGCATCAACACCGGCTTCGGCCTGCTCGCTTCGACGCGGATTGCCAGCGAAGACCTGGAAAAC
CTGCAGCGTTCGCTGGTGTTGTCGCATGCGGCCGGTGTCGGTCAGCCGATCAGCGATGAGCTGGTGCGTCTGATCATGGT
GCTCAAGGTCAACAGCCTGAGCCGCGGCTCCTCGGGCATTCGGCGCGTGGTCATCGACGCCCTGATTGCGCTGATCAATG
CCGAGGTCTACCCGCATATTCCGCTCAAGGGCTCGGTCGGTGCTTCCGGTGACCTGGCGCCGCTGGCGCACATGTCGCTG
GTGCTGCTGGGCGAAGGTAAGGCGCGCTACAAGGGCGAATGGCTGAACGGCGTCGACGCGCTGGCGGCTGCCGGGCTGCA
ACCGCTGACCCTCGCCGCCAAGGAAGGGCTGGCACTGCTCAACGGCACGCAAGTTTCCACCGCGTATGCACTGCGCGGCT
TGTTCGAGGGCGAAGACCTGTTCGCTGCGGCTCTGACTTGCGGCTCGTTGACTGTGGAAGCAGTACTCGGTTCGCGCTCG
CCCTTCGACGCGCGCATTCATGCCGCACGCGGGCAGCGCGGGCAGATCGACGCGGCGGCCTGCTACCGCGACCTGCTGGG
CGAAAGCAGCGGCGTGTCCGAGTCGCACCGCAATTGCGACAAGGTTCAGGACCCCTACTCGTTGCGCTGCCAGCCACAGG
TCATGGGCGCATGCCTGACACAGCTGCGTCAGGCCGCCGAGGTGCTGGAAATCGAAGCCAACGCGGTGTCCGACAACCCG
CTGGTGTTTGCCGCCGAGAACGACGTCATATCCGGTGGCAATTTTCACGCCGAGCCGGTCGCCATGGCAGCGGACAACCT
CGCGCTGGCCATCGCCGAGATCGGCTCGCTCAGCGAACGACGCATTTCGCTGATGATGGACAAGCACATGTCGCAGTTGC
CGCCCTTCCTGGTGGCCAACGGCGGCGTCAATTCCGGGTTCATGATCGCGCAGGTGACCGCCGCCGCACTGGCCAGTGAA
AACAAGGCATTGGCCCATCCACACAGTGTCGACAGCCTGCCAACCTCGGCCAATCAGGAAGACCATGTGTCGATGGCCCC
GGCCGCCGGCAAGCGCTTATGGGAAATGGCAGAAAACGTTCGCGGGATTCTTGCCGTAGAATGGTTGGCTGCCTGCCAGG
GTCTGGACTTGCGTGAAGGTCTGAAAACCTCTCCGAAGCTGGAGCAAGCCCGCAGCCTGTTGCGCAGCAAGGTCCCGTTC
TATGAAAAGGACCGCTTTTTTGCACCGGACATCGAAGCTGCCAGTCAGCTGCTGTCCTCCACTTGCCTGAACCCGCTGGT
TCCTGCACGTCTGCTACCGAGTCTGTGA

Upstream 100 bases:

>100_bases
GGAAAGGGTTTTCCAGCACTGCCGTGACAACGCGGCAGGCCTATAAAAGCAGCGTACGGCCACACGCCGTCGCTGACACT
TATCAAGGAGTAGCAGCATC

Downstream 100 bases:

>100_bases
TGCACCGCGAGCCTGGCAGGGCTCGCTTTGGTCATCGCTGCGGGAGGCCGGATGCAGGCGTTCTCGCGGCTTTTGCCATA
CCTGTAATGAAATGGACCTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTTLSAKTLNLIPSQLTLAQLRGIYLQPVSLTLDSSANQQIDDSVACVERILAENRTAYGINTGFGLLASTRIASEDLEN
LQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGSSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSL
VLLGEGKARYKGEWLNGVDALAAAGLQPLTLAAKEGLALLNGTQVSTAYALRGLFEGEDLFAAALTCGSLTVEAVLGSRS
PFDARIHAARGQRGQIDAAACYRDLLGESSGVSESHRNCDKVQDPYSLRCQPQVMGACLTQLRQAAEVLEIEANAVSDNP
LVFAAENDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASE
NKALAHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENVRGILAVEWLAACQGLDLREGLKTSPKLEQARSLLRSKVPF
YEKDRFFAPDIEAASQLLSSTCLNPLVPARLLPSL

Sequences:

>Translated_515_residues
MTTLSAKTLNLIPSQLTLAQLRGIYLQPVSLTLDSSANQQIDDSVACVERILAENRTAYGINTGFGLLASTRIASEDLEN
LQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGSSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSL
VLLGEGKARYKGEWLNGVDALAAAGLQPLTLAAKEGLALLNGTQVSTAYALRGLFEGEDLFAAALTCGSLTVEAVLGSRS
PFDARIHAARGQRGQIDAAACYRDLLGESSGVSESHRNCDKVQDPYSLRCQPQVMGACLTQLRQAAEVLEIEANAVSDNP
LVFAAENDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASE
NKALAHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENVRGILAVEWLAACQGLDLREGLKTSPKLEQARSLLRSKVPF
YEKDRFFAPDIEAASQLLSSTCLNPLVPARLLPSL
>Mature_514_residues
TTLSAKTLNLIPSQLTLAQLRGIYLQPVSLTLDSSANQQIDDSVACVERILAENRTAYGINTGFGLLASTRIASEDLENL
QRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGSSGIRRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLV
LLGEGKARYKGEWLNGVDALAAAGLQPLTLAAKEGLALLNGTQVSTAYALRGLFEGEDLFAAALTCGSLTVEAVLGSRSP
FDARIHAARGQRGQIDAAACYRDLLGESSGVSESHRNCDKVQDPYSLRCQPQVMGACLTQLRQAAEVLEIEANAVSDNPL
VFAAENDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASEN
KALAHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENVRGILAVEWLAACQGLDLREGLKTSPKLEQARSLLRSKVPFY
EKDRFFAPDIEAASQLLSSTCLNPLVPARLLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=45.3629032258064, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=473, Percent_Identity=42.2832980972516, Blast_Score=357, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54608; Mature: 54477

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLSAKTLNLIPSQLTLAQLRGIYLQPVSLTLDSSANQQIDDSVACVERILAENRTAYG
CCCCCCHHHHHCCHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
INTGFGLLASTRIASEDLENLQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGSSGI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
RRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYKGEWLNGVDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCHHHHHHH
LAAAGLQPLTLAAKEGLALLNGTQVSTAYALRGLFEGEDLFAAALTCGSLTVEAVLGSRS
HHHCCCCCEEHHHHCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCC
PFDARIHAARGQRGQIDAAACYRDLLGESSGVSESHRNCDKVQDPYSLRCQPQVMGACLT
CCCHHEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHCHHHCCCCCCCCCCHHHHHHHHH
QLRQAAEVLEIEANAVSDNPLVFAAENDVISGGNFHAEPVAMAADNLALAIAEIGSLSER
HHHHHHHHHHHCCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHH
RISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQE
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DHVSMAPAAGKRLWEMAENVRGILAVEWLAACQGLDLREGLKTSPKLEQARSLLRSKVPF
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCC
YEKDRFFAPDIEAASQLLSSTCLNPLVPARLLPSL
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
TTLSAKTLNLIPSQLTLAQLRGIYLQPVSLTLDSSANQQIDDSVACVERILAENRTAYG
CCCCCHHHHHCCHHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
INTGFGLLASTRIASEDLENLQRSLVLSHAAGVGQPISDELVRLIMVLKVNSLSRGSSGI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
RRVVIDALIALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYKGEWLNGVDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCHHHHHHH
LAAAGLQPLTLAAKEGLALLNGTQVSTAYALRGLFEGEDLFAAALTCGSLTVEAVLGSRS
HHHCCCCCEEHHHHCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCC
PFDARIHAARGQRGQIDAAACYRDLLGESSGVSESHRNCDKVQDPYSLRCQPQVMGACLT
CCCHHEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHCHHHCCCCCCCCCCHHHHHHHHH
QLRQAAEVLEIEANAVSDNPLVFAAENDVISGGNFHAEPVAMAADNLALAIAEIGSLSER
HHHHHHHHHHHCCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHH
RISLMMDKHMSQLPPFLVANGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQE
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DHVSMAPAAGKRLWEMAENVRGILAVEWLAACQGLDLREGLKTSPKLEQARSLLRSKVPF
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCC
YEKDRFFAPDIEAASQLLSSTCLNPLVPARLLPSL
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]