Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 66047361

GI number: 66047361

Start: 4925266

End: 4925901

Strand: Reverse

Name: hisG [H]

Synonym: Psyr_4134

Alternate gene names: 66047361

Gene position: 4925901-4925266 (Counterclockwise)

Preceding gene: 66047362

Following gene: 66047360

Centisome position: 80.84

GC content: 60.85

Gene sequence:

>636_bases
ATGTTGACCATCGCACTGTCCAAGGGCCGCATTCTTGACGACACCCTGCCGCTTCTCGCTGAAGCGGGCATCGTGCCGAC
CGAGAATCCGGACAAGAGCCGCAAGCTCATCATCCCCACGACTCAGGCCGATGTGCGCCTGCTGATCGTACGCGCCACCG
ACGTGCCGACCTATGTCGAGCATGGTGCCGCCGATCTGGGCGTCGCAGGCAAGGATGTGTTGATGGAATACACCGGTCAG
GGCCTGTATGAGCCGCTGGACCTGCAGATTGCCAAATGCAGGCTGATGACTGCGGGTGCCATTGGGGCGGTCGAGCCCAA
GGGCCGTCTGCGCGTAGCGACCAAGTTTGTCAACGTTGCCAAGCGTTACTACGCCGAGCAGGGGCGTCAGGTCGATATCA
TCAAGTTGTATGGCTCCATGGAGCTGGCGCCTCTGATTGGTCTGGCAGACAAGATCATCGACGTGGTCGACACCGGTAAC
ACCTTGCGCGCCAACGGCCTCGAGCCTCAGGAACTGATCGCGACCATCAGCTCGCGTCTGGTGGTGAACAAGGCCTCCAT
GAAGATGCAGCACGCACGCATTCAGGCCCTCATCGACACCCTGCGCAAGGCAGTGGAGTCGCGACACCGTAGCTGA

Upstream 100 bases:

>100_bases
GTGATTTCTGATTCGTTTCACTTCAGGTCAACAGGCCTGAGGGTTGTCATGCGCCGCTTGCGTCGTGACAAAAGTTTCCT
GATAAGGACTTACGTTTCCC

Downstream 100 bases:

>100_bases
TTCATTCACGCAACGTTGAGTTGCGTCCAGCTATCCGTGTCATAGCCAGATTTCTCAGGTGCCTGCGCGGATAGCTTGGT
AGCTTTAGGCTCCTGAGCAT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQADVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAKCRLMTAGAIGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRS

Sequences:

>Translated_211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQADVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAKCRLMTAGAIGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRS
>Mature_211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQADVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAKCRLMTAGAIGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=214, Percent_Identity=35.0467289719626, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=211, Percent_Identity=28.9099526066351, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 22995; Mature: 22995

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQADVRLLIVRATDVPTYVE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCHHHH
HGAADLGVAGKDVLMEYTGQGLYEPLDLQIAKCRLMTAGAIGAVEPKGRLRVATKFVNVA
CCCCCCCCCCHHHHHHHCCCCCCCCHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGNTLRANGLEPQELIATISSRL
HHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
VVNKASMKMQHARIQALIDTLRKAVESRHRS
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQADVRLLIVRATDVPTYVE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCHHHH
HGAADLGVAGKDVLMEYTGQGLYEPLDLQIAKCRLMTAGAIGAVEPKGRLRVATKFVNVA
CCCCCCCCCCHHHHHHHCCCCCCCCHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGNTLRANGLEPQELIATISSRL
HHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
VVNKASMKMQHARIQALIDTLRKAVESRHRS
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA