Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 66047360

GI number: 66047360

Start: 4923796

End: 4925142

Strand: Reverse

Name: hisD [H]

Synonym: Psyr_4133

Alternate gene names: 66047360

Gene position: 4925142-4923796 (Counterclockwise)

Preceding gene: 66047361

Following gene: 66047359

Centisome position: 80.82

GC content: 62.36

Gene sequence:

>1347_bases
ATGACCACTCCCACTGCAATTCGCCGACTCGACGCTGCTGACCCGGATTTCGCACGACATCTGGATCATCTGCTGAGCTG
GGAAAGTGTGTCTGACGATTCGGTCAACCAGCGCGTGCTCGACATCATCAAGGCGGTGCGTGAGCGTGGCGACGCGGCGC
TGGTCGAGTTCACCCAGAAGTTCGACGGGCTGCAGGTCGCGTCGATGGCGGACCTGATCCTGCCTCGCGAGCGTCTGGAA
CTTGCGTTGACGCGCATTACCCCGGGTCAGCGCGAAGCCCTGGAAAAGGCCGCCGAGCGTGTGCGCAGCTACCACGAAAA
GCAGAAGCAGGACTCCTGGAGCTACACCGAGGCCGACGGCACGGTGCTGGGCCAGAAGGTTACGCCGCTGGACCGTGCAG
GCCTGTACGTGCCGGGTGGCAAGGCTTCCTACCCGTCGTCGGTTTTGATGAATGCCATACCGGCCAAGGTGGCAGGTGTG
ACCGAGGTGGTGATGGTCGTGCCTACGCCGCGTGGTGAAATCAACGAGCTGGTGCTGGCCGCTGCCTGCATTGCAGGTGT
CGATCGGGTGTTCACCATCGGCGGTGCGCAAGCTGTTGCAGCGCTGGCTTACGGTACTGAAAGCGTGCCGAAAGTCGACA
AGGTGGTCGGCCCTGGCAATATCTATGTGGCGACCGCCAAGCGTCACGTGTTCGGTCAGGTGGGGATCGACATGATCGCC
GGTCCTTCCGAGATTCTGGTGGTGTGTGACGGTCAGACCGATCCTGACTGGATTGCCATGGACCTGTTCTCGCAGGCCGA
ACACGACGAAGATGCCCAGGCCATCCTGGTCAGTCCGGATGCCGAATTTCTCGACAAGGTGGCGGCCAGCATCACCCGTC
TGTTGCCGACCATGGAGCGGGCGGCCATCGTCGAAACGTCGATCAACGGTCGCGGCGCGCTGATAAAGGTGGCTGACATG
GCCCAGGCCATCGAAGTCGCCAATCGCATTGCGCCCGAGCACCTCGAACTGTCGGTCGCCGATCCGGAAGCCTGGCTGCC
GCAGATTCGCCATGCGGGTGCGATCTTCATGGGGCGTCACACCTCCGAAGCACTGGGCGACTATTGCGCAGGTCCCAACC
ACGTGCTGCCGACCTCCGGCACGGCGCGTTTTTCCTCGCCGCTGGGCGTCTACGATTTCCAGAAGCGCTCGTCGATCATC
TATTGCTCGCCGCAAGGTGCGTCCGAGCTGGGCAAGACGGCGTCCGTGCTGGCTCGTGGCGAATCCCTGAGCGGCCACGC
GCGCAGTGCCGAATATCGAATCACTGACCCTGACTGGACAGCAGGCAACAAAGAGGACGGCAAATAA

Upstream 100 bases:

>100_bases
CGTCCAGCTATCCGTGTCATAGCCAGATTTCTCAGGTGCCTGCGCGGATAGCTTGGTAGCTTTAGGCTCCTGAGCATCCG
CCAATTATTGAGGCCCCGCT

Downstream 100 bases:

>100_bases
TGAGCAAATTCTGGAGCCCTTTTGTCAGCGATCTGGTGCCTTATGTGCCGGGCGAACAGCCGAAACTGACCCGACTGGTC
AAGCTCAATACCAATGAAAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPRERLE
LALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGV
TEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIA
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRGALIKVADM
AQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSII
YCSPQGASELGKTASVLARGESLSGHARSAEYRITDPDWTAGNKEDGK

Sequences:

>Translated_448_residues
MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPRERLE
LALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGV
TEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIA
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRGALIKVADM
AQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSII
YCSPQGASELGKTASVLARGESLSGHARSAEYRITDPDWTAGNKEDGK
>Mature_447_residues
TTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPRERLEL
ALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVT
EVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIAG
PSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRGALIKVADMA
QAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIY
CSPQGASELGKTASVLARGESLSGHARSAEYRITDPDWTAGNKEDGK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=39.8104265402844, Blast_Score=292, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=405, Percent_Identity=37.037037037037, Blast_Score=258, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48074; Mature: 47943

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQK
CCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FDGLQVASMADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADG
CCCEEHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
TVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLA
CEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHH
AACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIA
HHHHHCCHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHCCHHEEC
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMER
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AAIVETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRH
HHEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECC
TSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARG
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCHHHHHHHHHHHHCC
ESLSGHARSAEYRITDPDWTAGNKEDGK
CCCCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQK
CCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FDGLQVASMADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADG
CCCEEHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
TVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLA
CEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHH
AACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIA
HHHHHCCHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHCCHHEEC
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMER
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AAIVETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRH
HHEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECC
TSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARG
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCHHHHHHHHHHHHCC
ESLSGHARSAEYRITDPDWTAGNKEDGK
CCCCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA