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The map label for this gene is recQ [H]

Identifier: 66047032

GI number: 66047032

Start: 4522205

End: 4524301

Strand: Direct

Name: recQ [H]

Synonym: Psyr_3804

Alternate gene names: 66047032

Gene position: 4522205-4524301 (Clockwise)

Preceding gene: 66047031

Following gene: 66047033

Centisome position: 74.21

GC content: 52.89

Gene sequence:

>2097_bases
ATGCAACGGAACGATGCAGAGAAACTACTGAAAGTCGCCATCAACAACGGAGCCGCTACGTTTAGGGATGGGCAATGGGA
GGCGATTGATGCTCTGGTCAACCATCGCAAGAAACTGTTAGTCGTTCAACGCACTGGTTGGGGCAAGAGCTCTGTTTACT
TTATCAGCACGCGAATTCTGCGTGATCGAGGGCAAGGCCCAACCATAATCATATCGCCCCTACTAGCCCTGATGCGCAAT
CAGGTCGACGCAGCTCAGCGACTAGGGATCAATGCCGTTACCATTAACTCTACCAATACTGACGAATGGGAAAAGGCCCG
TCAGGATGTGCACGCCAACCGAGTAGATTGCTTGTTGATCTCACCAGAGCGGCTAGCAAATGACGGCTTCATGGAAACCT
TTCTGCAGCCCATCGCAGATCGCATCGGCTTGATGGTAATAGATGAGGCGCACTGCATTTCCGACTGGGGGCATGATTTC
CGGCCCGATTATCGCCGTATCGTCAACATTCTGCGCTTCCTTCCCCCCAACACACCCGTTTTGGGTACGACTGCGACTGC
AAATACTCGGGTGGTGAACGATATTCAGGCTCAGTTTGGAGATATAAACATCGTCCGTGGCCCTCTGGCCCGAGAAAGTT
TGGCGTTACAAAATTTGATCATGCCCGATCAAGCCAGCCGTCTGGCATGGCTGGCGCAGACCATTCCAACCTTACCTGGG
ACGGGCATCGTTTATGCGCTCACCCAGCGCGATAGTGAGCAGGTCGCCCGCTGGCTTCGCGCTAACGGAATCGATGCTGC
TTCCTATCACAGTGATGTCGCCCACTCTGACTTTGGCAATAGCGATCAATATCGCCAACATCTAGAAGATGAACTGCTGG
CAAACAAGCTCAAGGTGCTCGTCGCGACCACTGCGTTAGGTATGGGCTATGACAAGCCCGACCTTGGCTTCGTCATTCAC
TATCAAGCGCCTAGCTCGCTTGTTGCCTACTACCAGCAGGTCGGTCGGGCAGGACGGGCAATCGATTACTCACTCGGCTT
GCTCATGTCTGGGGAAGAGGACGAGAAAATTCATGCGTTTTTTAGACGCGCAGCTTTTCCTCCCGCAGGGCAGGTCAATC
ATTTGCTGAGTGTCCTAGCGAAATCCAATGGGCTGACGATTCGTGAACTAGAAGAGCACAGCAACCTCTCACATGGGCAG
ATTGAGAAAATTCTCAAGCTCCTGAGCGTGGAAAGCCCAGCGCCACTCATCAAGCACCAAAGCAAATGGCTACGCACCCC
AATCCATTACGAGCTGGATCAGAATCGTGTTAGCAGGCTTACCGAGCTACGAGAGCATGAATGGCAGCAGGTTCTGGCAT
ACTTGAATGAACCAAGGTGCCTTATGGCGTTCCTACGACATGCATTGGATGACGCGGAGAATGATGCTTGCGGGAAATGC
GTGCGCTGCCTAGAGAGGGAGTTGGTATCAAGTAAAGTAGACGGTAGATTGGTGCATCAAGCCGCTACCTTTATTCGCCA
TGCCGAGCTTCCAATCAAGCCCAAGAAGCAAATCGCCAAGGGAGGCTTTGAGTATTACGGCTTCCCGACCAACCTCCCTC
TCAACATACAGGCGGCTGAAGGTAGAGTCCTTTCACAATGGCGTGATGGAAGCTGGGGAGAATTAGCTGCCAACGGCAAG
GAGCTCGGCCATTTTGACGATGCTCTGGTTTCAGCCATGGCAGAAATGATCCAATCGCGCTGGCAACCGAATCCTAAACC
CACGTGGTTGTGCTGCGTGCCTTCTCTAGGGCATCCAATGTTAGTACCTGACTTTGCTCAGCGCTTGGCGAATGCATTGG
GGATCCCCTTCGTCAACTGTGTGACCAAGGTAAGGCAAAACGAGCCGCAAAAGTGGCAAAACAATCGCTTCCACCAGTGT
CGGAATCTAGATGGTGTGTTCGCCGTTAGTGCACATATTCCTCCTGGCCCGGTGCTGCTGGTTGATGACATGATCGATTC
AGGCTGGACAATGACCGTCATTGCCGCACTGCTCAAACAAGCGGGCAGCGAACACGTCTACCCGCTGGCAATCTCATCTA
CGGCAAGCAACGCATGA

Upstream 100 bases:

>100_bases
GCGCTGCCAGACTCCATCCAAACCTCTTCGAGGGCTAACCCTCGCCCTTAGGAAATCTTGACCCGATACTTGTGAAGGGT
TGATCAAAAGGACTTATGTT

Downstream 100 bases:

>100_bases
TAAATACCAATACTCAGTCGATCCTCCTACTAACGTCTTATTTTTCAAAATCTGTAGGTGGTGCCAAACCGCTATCTCCG
ACGGAATGGGGACGATTTGC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MQRNDAEKLLKVAINNGAATFRDGQWEAIDALVNHRKKLLVVQRTGWGKSSVYFISTRILRDRGQGPTIIISPLLALMRN
QVDAAQRLGINAVTINSTNTDEWEKARQDVHANRVDCLLISPERLANDGFMETFLQPIADRIGLMVIDEAHCISDWGHDF
RPDYRRIVNILRFLPPNTPVLGTTATANTRVVNDIQAQFGDINIVRGPLARESLALQNLIMPDQASRLAWLAQTIPTLPG
TGIVYALTQRDSEQVARWLRANGIDAASYHSDVAHSDFGNSDQYRQHLEDELLANKLKVLVATTALGMGYDKPDLGFVIH
YQAPSSLVAYYQQVGRAGRAIDYSLGLLMSGEEDEKIHAFFRRAAFPPAGQVNHLLSVLAKSNGLTIRELEEHSNLSHGQ
IEKILKLLSVESPAPLIKHQSKWLRTPIHYELDQNRVSRLTELREHEWQQVLAYLNEPRCLMAFLRHALDDAENDACGKC
VRCLERELVSSKVDGRLVHQAATFIRHAELPIKPKKQIAKGGFEYYGFPTNLPLNIQAAEGRVLSQWRDGSWGELAANGK
ELGHFDDALVSAMAEMIQSRWQPNPKPTWLCCVPSLGHPMLVPDFAQRLANALGIPFVNCVTKVRQNEPQKWQNNRFHQC
RNLDGVFAVSAHIPPGPVLLVDDMIDSGWTMTVIAALLKQAGSEHVYPLAISSTASNA

Sequences:

>Translated_698_residues
MQRNDAEKLLKVAINNGAATFRDGQWEAIDALVNHRKKLLVVQRTGWGKSSVYFISTRILRDRGQGPTIIISPLLALMRN
QVDAAQRLGINAVTINSTNTDEWEKARQDVHANRVDCLLISPERLANDGFMETFLQPIADRIGLMVIDEAHCISDWGHDF
RPDYRRIVNILRFLPPNTPVLGTTATANTRVVNDIQAQFGDINIVRGPLARESLALQNLIMPDQASRLAWLAQTIPTLPG
TGIVYALTQRDSEQVARWLRANGIDAASYHSDVAHSDFGNSDQYRQHLEDELLANKLKVLVATTALGMGYDKPDLGFVIH
YQAPSSLVAYYQQVGRAGRAIDYSLGLLMSGEEDEKIHAFFRRAAFPPAGQVNHLLSVLAKSNGLTIRELEEHSNLSHGQ
IEKILKLLSVESPAPLIKHQSKWLRTPIHYELDQNRVSRLTELREHEWQQVLAYLNEPRCLMAFLRHALDDAENDACGKC
VRCLERELVSSKVDGRLVHQAATFIRHAELPIKPKKQIAKGGFEYYGFPTNLPLNIQAAEGRVLSQWRDGSWGELAANGK
ELGHFDDALVSAMAEMIQSRWQPNPKPTWLCCVPSLGHPMLVPDFAQRLANALGIPFVNCVTKVRQNEPQKWQNNRFHQC
RNLDGVFAVSAHIPPGPVLLVDDMIDSGWTMTVIAALLKQAGSEHVYPLAISSTASNA
>Mature_698_residues
MQRNDAEKLLKVAINNGAATFRDGQWEAIDALVNHRKKLLVVQRTGWGKSSVYFISTRILRDRGQGPTIIISPLLALMRN
QVDAAQRLGINAVTINSTNTDEWEKARQDVHANRVDCLLISPERLANDGFMETFLQPIADRIGLMVIDEAHCISDWGHDF
RPDYRRIVNILRFLPPNTPVLGTTATANTRVVNDIQAQFGDINIVRGPLARESLALQNLIMPDQASRLAWLAQTIPTLPG
TGIVYALTQRDSEQVARWLRANGIDAASYHSDVAHSDFGNSDQYRQHLEDELLANKLKVLVATTALGMGYDKPDLGFVIH
YQAPSSLVAYYQQVGRAGRAIDYSLGLLMSGEEDEKIHAFFRRAAFPPAGQVNHLLSVLAKSNGLTIRELEEHSNLSHGQ
IEKILKLLSVESPAPLIKHQSKWLRTPIHYELDQNRVSRLTELREHEWQQVLAYLNEPRCLMAFLRHALDDAENDACGKC
VRCLERELVSSKVDGRLVHQAATFIRHAELPIKPKKQIAKGGFEYYGFPTNLPLNIQAAEGRVLSQWRDGSWGELAANGK
ELGHFDDALVSAMAEMIQSRWQPNPKPTWLCCVPSLGHPMLVPDFAQRLANALGIPFVNCVTKVRQNEPQKWQNNRFHQC
RNLDGVFAVSAHIPPGPVLLVDDMIDSGWTMTVIAALLKQAGSEHVYPLAISSTASNA

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=348, Percent_Identity=34.4827586206897, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI14591902, Length=331, Percent_Identity=32.6283987915408, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI14591904, Length=331, Percent_Identity=32.6283987915408, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI51242943, Length=332, Percent_Identity=32.8313253012048, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI51242947, Length=332, Percent_Identity=32.8313253012048, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI148612816, Length=332, Percent_Identity=32.8313253012048, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI110735439, Length=346, Percent_Identity=28.9017341040462, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI169218196, Length=346, Percent_Identity=28.9017341040462, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI284005309, Length=340, Percent_Identity=31.4705882352941, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI48994977, Length=330, Percent_Identity=35.7575757575758, Blast_Score=179, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71987993, Length=346, Percent_Identity=33.5260115606936, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71987997, Length=346, Percent_Identity=33.5260115606936, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI32564293, Length=335, Percent_Identity=33.4328358208955, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25145561, Length=338, Percent_Identity=33.4319526627219, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17552866, Length=368, Percent_Identity=32.3369565217391, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI115533224, Length=382, Percent_Identity=22.2513089005236, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=335, Percent_Identity=32.8358208955224, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24646066, Length=355, Percent_Identity=32.6760563380282, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI62472181, Length=333, Percent_Identity=32.7327327327327, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24664230, Length=333, Percent_Identity=32.7327327327327, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24664226, Length=333, Percent_Identity=32.7327327327327, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21358123, Length=353, Percent_Identity=31.4447592067989, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574962, Length=324, Percent_Identity=25.6172839506173, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644487, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551833, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644485, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24644483, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281361218, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24644481, Length=316, Percent_Identity=24.0506329113924, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24644479, Length=316, Percent_Identity=24.3670886075949, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18857967, Length=242, Percent_Identity=28.5123966942149, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77937; Mature: 77937

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00690 DEAH_ATP_HELICASE ; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRNDAEKLLKVAINNGAATFRDGQWEAIDALVNHRKKLLVVQRTGWGKSSVYFISTRIL
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEHHHH
RDRGQGPTIIISPLLALMRNQVDAAQRLGINAVTINSTNTDEWEKARQDVHANRVDCLLI
HHCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
SPERLANDGFMETFLQPIADRIGLMVIDEAHCISDWGHDFRPDYRRIVNILRFLPPNTPV
CHHHHCCCHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCE
LGTTATANTRVVNDIQAQFGDINIVRGPLARESLALQNLIMPDQASRLAWLAQTIPTLPG
EECCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
TGIVYALTQRDSEQVARWLRANGIDAASYHSDVAHSDFGNSDQYRQHLEDELLANKLKVL
CCEEEEEECCCHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VATTALGMGYDKPDLGFVIHYQAPSSLVAYYQQVGRAGRAIDYSLGLLMSGEEDEKIHAF
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECEEECCCCCHHHHHH
FRRAAFPPAGQVNHLLSVLAKSNGLTIRELEEHSNLSHGQIEKILKLLSVESPAPLIKHQ
HHHHCCCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHH
SKWLRTPIHYELDQNRVSRLTELREHEWQQVLAYLNEPRCLMAFLRHALDDAENDACGKC
HHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
VRCLERELVSSKVDGRLVHQAATFIRHAELPIKPKKQIAKGGFEYYGFPTNLPLNIQAAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEECCCCCCCEEEECCC
GRVLSQWRDGSWGELAANGKELGHFDDALVSAMAEMIQSRWQPNPKPTWLCCVPSLGHPM
CHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
LVPDFAQRLANALGIPFVNCVTKVRQNEPQKWQNNRFHQCRNLDGVFAVSAHIPPGPVLL
CCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCEEEEEECCCCCCEEE
VDDMIDSGWTMTVIAALLKQAGSEHVYPLAISSTASNA
EECHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MQRNDAEKLLKVAINNGAATFRDGQWEAIDALVNHRKKLLVVQRTGWGKSSVYFISTRIL
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEHHHH
RDRGQGPTIIISPLLALMRNQVDAAQRLGINAVTINSTNTDEWEKARQDVHANRVDCLLI
HHCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEE
SPERLANDGFMETFLQPIADRIGLMVIDEAHCISDWGHDFRPDYRRIVNILRFLPPNTPV
CHHHHCCCHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCE
LGTTATANTRVVNDIQAQFGDINIVRGPLARESLALQNLIMPDQASRLAWLAQTIPTLPG
EECCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
TGIVYALTQRDSEQVARWLRANGIDAASYHSDVAHSDFGNSDQYRQHLEDELLANKLKVL
CCEEEEEECCCHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VATTALGMGYDKPDLGFVIHYQAPSSLVAYYQQVGRAGRAIDYSLGLLMSGEEDEKIHAF
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECEEECCCCCHHHHHH
FRRAAFPPAGQVNHLLSVLAKSNGLTIRELEEHSNLSHGQIEKILKLLSVESPAPLIKHQ
HHHHCCCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHH
SKWLRTPIHYELDQNRVSRLTELREHEWQQVLAYLNEPRCLMAFLRHALDDAENDACGKC
HHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
VRCLERELVSSKVDGRLVHQAATFIRHAELPIKPKKQIAKGGFEYYGFPTNLPLNIQAAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEECCCCCCCEEEECCC
GRVLSQWRDGSWGELAANGKELGHFDDALVSAMAEMIQSRWQPNPKPTWLCCVPSLGHPM
CHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
LVPDFAQRLANALGIPFVNCVTKVRQNEPQKWQNNRFHQCRNLDGVFAVSAHIPPGPVLL
CCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCEEEEEECCCCCCEEE
VDDMIDSGWTMTVIAALLKQAGSEHVYPLAISSTASNA
EECHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]