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The map label for this gene is cpxA [H]

Identifier: 66047020

GI number: 66047020

Start: 4508297

End: 4509547

Strand: Reverse

Name: cpxA [H]

Synonym: Psyr_3792

Alternate gene names: 66047020

Gene position: 4509547-4508297 (Counterclockwise)

Preceding gene: 66047021

Following gene: 66047019

Centisome position: 74.0

GC content: 62.91

Gene sequence:

>1251_bases
ATGAGGCCGAACCGGCTGTTCTGGAAGCTGTTCCTGGCATTCTGGCTAGCGACCAGCCTGACCTTCATGGTCGGTGCCGG
CCTGTTCATGTTCACCCAGTCAGGGCGGGGCGATCCTTCGTTCAGCACGGTGCTCGATAACGAAGTGCGCATTTTGCAGC
GCTCGGGCATTGCCGCAGGGCAGGCGTTGCTCGATGCCTGGCAGCCGGAGGGGCAAGGCAGGGTCGGGCTGTACGACAAC
CAGGGTCTGCTGCTGGCGGGCGAGGCGCTGGAGAATCCTCGCTTCGAACTGGCTGTGCACACACGCGAAGGTGCACTCGT
GCACATCCGCTCTACCCAGCGCCCCAACCATGACGATCAACCTTCTCACCTCAATCCGCTGATCACCGGCACGGTCATGA
GTGCGCTGTTCAGCTGGTTTCTCAGCAGCTATCTGGTGGCGCCGCTGATGAAATTGCGAGAGGCGATGGGCAAGGTCGCC
AGAGGCCGTTTCGACACACGGGTAAAACCCGACATGGGCCGGCGGCGCGATGAAATCGTCGACCTTGCCGAGGATTGCGA
CCGCATGGCCAATCAGCTCAAGGTCATGGCCGACTCCCAGCAACAACTGCTGCATGATATTTCCCATGAGCTGCGTTCGC
CGCTGACGCGCATGAGTGCCGCCATCGGCCTGTTGCGCCAGGAGCCGACCCAACTGGACATGCTCGAACGCATCGAGCGC
GAATCGGAGCGCATGGACTCACTGATCGAAGAATTGCTGACCCTGGCGCGCATGCAGAGCGATGTCGAAAGCCTGACGCG
GGAAAAGGTCGATGTCATCAGCCTGCTGGCGGCCATCGTCGAGGATGCCGAATTCGAGGCCGGACTGAAGCAGTGTTGGG
TCAGGCTGCAGGCTCCCGGGTCTTTCGTCGCGCAGGTCGACAGCGAACTGCTCTACCGGGCCTTCGAAAACGTGATCCGC
AATGCCGTTCGCCACACGGCGGTCGGCACGGATGTGGTGGTTGTCGCCAACGTTCAGGCCCAGCCGCTGTGCCTGATGGT
CAATGTCATCGATCAGGGGCCAGGTGTGGACGAGGCGTGCCTGCAACGGATTTTCCAGCCCTTCGAGCGCGGCCCGGAGA
ATGCCGCGCAGGGCTTTGGCCTGGGCCTGGCCATCGCCCTGCGGGCTATCGAAATGCACGGCGGGCAGATCGCCGCGCGC
AATAGGCCCGGCGGCGGTCTGGTGGTCGATGTGCTGCTGCCGGTGTCGTGA

Upstream 100 bases:

>100_bases
ATGTGCACATCAGCAGCATTCGCCACAAACTCGGGCCGCGCAACGATAACCAGAGCTGGATACAGAGCGTGCGCAATCTG
GGCTATATGTTGCTCACGCC

Downstream 100 bases:

>100_bases
CGGCGCTTGCTGGTTTTGCCGCGTTTCGAATGGCCGTTATCCGCCCGTTGGTAAACAAAATCGGCCTTTGGTGGTAAAGA
AACTCGGCCCCGGCGCTCGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRPNRLFWKLFLAFWLATSLTFMVGAGLFMFTQSGRGDPSFSTVLDNEVRILQRSGIAAGQALLDAWQPEGQGRVGLYDN
QGLLLAGEALENPRFELAVHTREGALVHIRSTQRPNHDDQPSHLNPLITGTVMSALFSWFLSSYLVAPLMKLREAMGKVA
RGRFDTRVKPDMGRRRDEIVDLAEDCDRMANQLKVMADSQQQLLHDISHELRSPLTRMSAAIGLLRQEPTQLDMLERIER
ESERMDSLIEELLTLARMQSDVESLTREKVDVISLLAAIVEDAEFEAGLKQCWVRLQAPGSFVAQVDSELLYRAFENVIR
NAVRHTAVGTDVVVVANVQAQPLCLMVNVIDQGPGVDEACLQRIFQPFERGPENAAQGFGLGLAIALRAIEMHGGQIAAR
NRPGGGLVVDVLLPVS

Sequences:

>Translated_416_residues
MRPNRLFWKLFLAFWLATSLTFMVGAGLFMFTQSGRGDPSFSTVLDNEVRILQRSGIAAGQALLDAWQPEGQGRVGLYDN
QGLLLAGEALENPRFELAVHTREGALVHIRSTQRPNHDDQPSHLNPLITGTVMSALFSWFLSSYLVAPLMKLREAMGKVA
RGRFDTRVKPDMGRRRDEIVDLAEDCDRMANQLKVMADSQQQLLHDISHELRSPLTRMSAAIGLLRQEPTQLDMLERIER
ESERMDSLIEELLTLARMQSDVESLTREKVDVISLLAAIVEDAEFEAGLKQCWVRLQAPGSFVAQVDSELLYRAFENVIR
NAVRHTAVGTDVVVVANVQAQPLCLMVNVIDQGPGVDEACLQRIFQPFERGPENAAQGFGLGLAIALRAIEMHGGQIAAR
NRPGGGLVVDVLLPVS
>Mature_416_residues
MRPNRLFWKLFLAFWLATSLTFMVGAGLFMFTQSGRGDPSFSTVLDNEVRILQRSGIAAGQALLDAWQPEGQGRVGLYDN
QGLLLAGEALENPRFELAVHTREGALVHIRSTQRPNHDDQPSHLNPLITGTVMSALFSWFLSSYLVAPLMKLREAMGKVA
RGRFDTRVKPDMGRRRDEIVDLAEDCDRMANQLKVMADSQQQLLHDISHELRSPLTRMSAAIGLLRQEPTQLDMLERIER
ESERMDSLIEELLTLARMQSDVESLTREKVDVISLLAAIVEDAEFEAGLKQCWVRLQAPGSFVAQVDSELLYRAFENVIR
NAVRHTAVGTDVVVVANVQAQPLCLMVNVIDQGPGVDEACLQRIFQPFERGPENAAQGFGLGLAIALRAIEMHGGQIAAR
NRPGGGLVVDVLLPVS

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=35.1648351648352, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=30.2158273381295, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=26.4957264957265, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=30.9623430962343, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=26.8817204301075, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=26.615969581749, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790861, Length=248, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=331, Percent_Identity=24.4712990936556, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=26.3392857142857, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=27.2, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=318, Percent_Identity=25.7861635220126, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=25.5230125523013, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=25.9911894273128, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=28.8702928870293, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=25.3164556962025, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46131; Mature: 46131

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPNRLFWKLFLAFWLATSLTFMVGAGLFMFTQSGRGDPSFSTVLDNEVRILQRSGIAAG
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHCCCHHH
QALLDAWQPEGQGRVGLYDNQGLLLAGEALENPRFELAVHTREGALVHIRSTQRPNHDDQ
HHHHHHCCCCCCCCEEEECCCCEEEECHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCC
PSHLNPLITGTVMSALFSWFLSSYLVAPLMKLREAMGKVARGRFDTRVKPDMGRRRDEIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
DLAEDCDRMANQLKVMADSQQQLLHDISHELRSPLTRMSAAIGLLRQEPTQLDMLERIER
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ESERMDSLIEELLTLARMQSDVESLTREKVDVISLLAAIVEDAEFEAGLKQCWVRLQAPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SFVAQVDSELLYRAFENVIRNAVRHTAVGTDVVVVANVQAQPLCLMVNVIDQGPGVDEAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHH
LQRIFQPFERGPENAAQGFGLGLAIALRAIEMHGGQIAARNRPGGGLVVDVLLPVS
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRPNRLFWKLFLAFWLATSLTFMVGAGLFMFTQSGRGDPSFSTVLDNEVRILQRSGIAAG
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHCCCHHH
QALLDAWQPEGQGRVGLYDNQGLLLAGEALENPRFELAVHTREGALVHIRSTQRPNHDDQ
HHHHHHCCCCCCCCEEEECCCCEEEECHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCC
PSHLNPLITGTVMSALFSWFLSSYLVAPLMKLREAMGKVARGRFDTRVKPDMGRRRDEIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
DLAEDCDRMANQLKVMADSQQQLLHDISHELRSPLTRMSAAIGLLRQEPTQLDMLERIER
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ESERMDSLIEELLTLARMQSDVESLTREKVDVISLLAAIVEDAEFEAGLKQCWVRLQAPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
SFVAQVDSELLYRAFENVIRNAVRHTAVGTDVVVVANVQAQPLCLMVNVIDQGPGVDEAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHH
LQRIFQPFERGPENAAQGFGLGLAIALRAIEMHGGQIAARNRPGGGLVVDVLLPVS
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]