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The map label for this gene is cpxR [H]

Identifier: 66047021

GI number: 66047021

Start: 4509544

End: 4510233

Strand: Reverse

Name: cpxR [H]

Synonym: Psyr_3793

Alternate gene names: 66047021

Gene position: 4510233-4509544 (Counterclockwise)

Preceding gene: 66047024

Following gene: 66047020

Centisome position: 74.01

GC content: 61.59

Gene sequence:

>690_bases
ATGACTTCCGTATTGCTTGTCGACGATGACCGGGAACTGACGGAAATGCTCAGCCAGTACCTGACCCGTGAAAGCTTCGA
CGTGACCTGCACCAACAGCGCTGAAGAGGGCGAGATTGAAGCCTTGTCCGGGCGTCACGACATCGTTGTGCTGGACATCA
TGATGCCGCGCATCTCCGGGATCGAAGTGCTGCGGCGGATCCGTGCGCAAAGCCAGGTGCCGGTGATTCTGCTGACCGCC
CGCGGCGACAATATCGACCGTATTTCCGGGCTGGAACTGGGCGCCGACGATTACGTGCCCAAGCCCAGCTCGCCGGGTGA
ACTGGTGGCGCGTCTGCGGGCGATCATGCGCCGGGTGCGTGCGGTGTCGGTAGTCGATGCGGTCAGGGATGTGATTCAGG
CCGGAGAGCTGATGCTCTGGCCAGGCAAGCGTGAAGCGCGCTGGCAGGGCGTGACGCTTGAACTGACCGGCAACGAGTTC
TGCCTGCTCGAAGAGCTGGCGCGGCATGCCGGGCAACTGGTCAGCAAACAGAACCTGTCGATGAACGCGCTGGGACGGCC
GCTGGCGCGCTACGATCGCAGTATCGATGTGCACATCAGCAGCATTCGCCACAAACTCGGGCCGCGCAACGATAACCAGA
GCTGGATACAGAGCGTGCGCAATCTGGGCTATATGTTGCTCACGCCATGA

Upstream 100 bases:

>100_bases
GACGGTTAACGCCGTGTAAGGTTAGGTAAAGATCATCGAGCCCGGCTGACACGCCGCAGCAGCGTCGGGATAATCGGCAA
CCACCAATCAAGGGCCTGCC

Downstream 100 bases:

>100_bases
GGCCGAACCGGCTGTTCTGGAAGCTGTTCCTGGCATTCTGGCTAGCGACCAGCCTGACCTTCATGGTCGGTGCCGGCCTG
TTCATGTTCACCCAGTCAGG

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTSVLLVDDDRELTEMLSQYLTRESFDVTCTNSAEEGEIEALSGRHDIVVLDIMMPRISGIEVLRRIRAQSQVPVILLTA
RGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRVRAVSVVDAVRDVIQAGELMLWPGKREARWQGVTLELTGNEF
CLLEELARHAGQLVSKQNLSMNALGRPLARYDRSIDVHISSIRHKLGPRNDNQSWIQSVRNLGYMLLTP

Sequences:

>Translated_229_residues
MTSVLLVDDDRELTEMLSQYLTRESFDVTCTNSAEEGEIEALSGRHDIVVLDIMMPRISGIEVLRRIRAQSQVPVILLTA
RGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRVRAVSVVDAVRDVIQAGELMLWPGKREARWQGVTLELTGNEF
CLLEELARHAGQLVSKQNLSMNALGRPLARYDRSIDVHISSIRHKLGPRNDNQSWIQSVRNLGYMLLTP
>Mature_228_residues
TSVLLVDDDRELTEMLSQYLTRESFDVTCTNSAEEGEIEALSGRHDIVVLDIMMPRISGIEVLRRIRAQSQVPVILLTAR
GDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRVRAVSVVDAVRDVIQAGELMLWPGKREARWQGVTLELTGNEFC
LLEELARHAGQLVSKQNLSMNALGRPLARYDRSIDVHISSIRHKLGPRNDNQSWIQSVRNLGYMLLTP

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=45.8874458874459, Blast_Score=196, Evalue=8e-52,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=38.4279475982533, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.8214285714286, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=36.4444444444444, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.9344978165939, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=34.2105263157895, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=33.9285714285714, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=32.1888412017167, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=33.1858407079646, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786911, Length=206, Percent_Identity=31.5533980582524, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=29.0178571428571, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=207, Percent_Identity=32.3671497584541, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=29.4642857142857, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25683; Mature: 25552

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVLLVDDDRELTEMLSQYLTRESFDVTCTNSAEEGEIEALSGRHDIVVLDIMMPRISG
CCEEEEEECCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCEEEEEECCCCCHH
IEVLRRIRAQSQVPVILLTARGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRVR
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
AVSVVDAVRDVIQAGELMLWPGKREARWQGVTLELTGNEFCLLEELARHAGQLVSKQNLS
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
MNALGRPLARYDRSIDVHISSIRHKLGPRNDNQSWIQSVRNLGYMLLTP
HHHHCCHHHHHCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCEEEECC
>Mature Secondary Structure 
TSVLLVDDDRELTEMLSQYLTRESFDVTCTNSAEEGEIEALSGRHDIVVLDIMMPRISG
CEEEEEECCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCEEEEEECCCCCHH
IEVLRRIRAQSQVPVILLTARGDNIDRISGLELGADDYVPKPSSPGELVARLRAIMRRVR
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
AVSVVDAVRDVIQAGELMLWPGKREARWQGVTLELTGNEFCLLEELARHAGQLVSKQNLS
HHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
MNALGRPLARYDRSIDVHISSIRHKLGPRNDNQSWIQSVRNLGYMLLTP
HHHHCCHHHHHCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]