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The map label for this gene is apt [H]

Identifier: 66046655

GI number: 66046655

Start: 4090266

End: 4090814

Strand: Direct

Name: apt [H]

Synonym: Psyr_3426

Alternate gene names: 66046655

Gene position: 4090266-4090814 (Clockwise)

Preceding gene: 66046654

Following gene: 161486730

Centisome position: 67.12

GC content: 59.2

Gene sequence:

>549_bases
ATGACTTTCGATCAATCGAACTTCAAATCCCTCATCCGCCCGGTCGTGGACTTCCCCAAGCCGGGTGTGGTCTTCCGTGA
TATCACGCCCCTCTTCCAATCGCCCAAGGCCACCCGCCAGGTGATTGACAGCTTCGTGCAGCGCTACATCGATGCCGAAT
TCAGCCACATCGGCGTGATGGACGCGCGGGGTTTTCTGATCGGTTCGGTGGTCGCGTATCAATTGAACAAGCCGCTGGTG
CTGTTCCGCAAACAAGGCAAGCTGCCCGCCGATGTACTGTCCGAGGCGTATCAGACCGAATACGGCGAAGCGTATCTGGA
AGTGCATGCCGACAGTCTGTGCGAAGGCGACTCGGTCGTCATGTTCGATGACCTCATCGCGACCGGAGGCACGCTGATCG
CCGCCGCCAACCTGATCCGCCGTATGGGTGCCGAAGTGTACGAGGCCGCTGCGATTATCGACCTGCCGGAACTGGGCGGC
TCCAAGCGTCTTAACGACCTGAAGATCCCGACGTTCTGCCTGACCGAGTTTGCGCTGGACGAGCAGTAA

Upstream 100 bases:

>100_bases
GAGCTGTGTGCGCTGGCTGGCGGGTCGATGCAAAGCTGAAACGTGCGATCTTTGGCGGGTCGGCTTAAACTGTCGGCCAA
AACTGCCATGGAACCCCCTG

Downstream 100 bases:

>100_bases
CGGCACAGGCACGAGAGTTACAGGTTCCAAACGGTCCAGCGCTCACGGCTATCGTAAATGCGCTTTTTTATCGCGATGGC
ACTGACGACGCAGAGTGCGA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTFDQSNFKSLIRPVVDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIDAEFSHIGVMDARGFLIGSVVAYQLNKPLV
LFRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGAEVYEAAAIIDLPELGG
SKRLNDLKIPTFCLTEFALDEQ

Sequences:

>Translated_182_residues
MTFDQSNFKSLIRPVVDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIDAEFSHIGVMDARGFLIGSVVAYQLNKPLV
LFRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGAEVYEAAAIIDLPELGG
SKRLNDLKIPTFCLTEFALDEQ
>Mature_181_residues
TFDQSNFKSLIRPVVDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIDAEFSHIGVMDARGFLIGSVVAYQLNKPLVL
FRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVVMFDDLIATGGTLIAAANLIRRMGAEVYEAAAIIDLPELGGS
KRLNDLKIPTFCLTEFALDEQ

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=42.3529411764706, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=45.0819672131148, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=46.4705882352941, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17509087, Length=175, Percent_Identity=41.7142857142857, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=32.5153374233129, Blast_Score=88, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=30.8641975308642, Blast_Score=71, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=38.3647798742138, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20154; Mature: 20023

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDQSNFKSLIRPVVDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIDAEFSHIGVM
CCCCHHHHHHHHHHHHCCCCCCEEHHCCHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCC
DARGFLIGSVVAYQLNKPLVLFRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVV
CCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEE
MFDDLIATGGTLIAAANLIRRMGAEVYEAAAIIDLPELGGSKRLNDLKIPTFCLTEFALD
EEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHCC
EQ
CC
>Mature Secondary Structure 
TFDQSNFKSLIRPVVDFPKPGVVFRDITPLFQSPKATRQVIDSFVQRYIDAEFSHIGVM
CCCHHHHHHHHHHHHCCCCCCEEHHCCHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCC
DARGFLIGSVVAYQLNKPLVLFRKQGKLPADVLSEAYQTEYGEAYLEVHADSLCEGDSVV
CCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEE
MFDDLIATGGTLIAAANLIRRMGAEVYEAAAIIDLPELGGSKRLNDLKIPTFCLTEFALD
EEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHCC
EQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA