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The map label for this gene is cynR [H]

Identifier: 161486730

GI number: 161486730

Start: 4153884

End: 4154762

Strand: Direct

Name: cynR [H]

Synonym: Psyr_3484

Alternate gene names: 161486730

Gene position: 4153884-4154762 (Clockwise)

Preceding gene: 66046655

Following gene: 66046716

Centisome position: 68.17

GC content: 60.86

Gene sequence:

>879_bases
GTGCTGTTACGCCATATACGTTATTTGCTGGCAGTCGCCGACCATGGCAATTTCACCCGGGCGGCCGAGGCCCTGCATGT
CTCGCAACCGGCGTTGTCGCAACAGATCAGGCAGCTGGAAAGCAGTCTGGGTGTGCAACTGTTCGACCGCACCCGCCGCA
GCGTCGTGCCGACCGATGCCGGCCGCGTGTATCTGGACCACGCGCGTCGCTGCCTGCTTGAGCTGGATGCCGGGAAGCGT
GCGCTCAACGATGTCAGCGACCTGTCACGCGGACAATTGCGCCTCGGCGTCACGCCTACCTTCAGTGAATACCTGATAGC
GCCGCTGATCGACCGCTTCAGCGCGCTGTATCCGGGAGTGGCAATCATCCTCACGGAGCTGCCTCTGGAGCAGATTACCG
AGGCACTGATCAGTGACGCGCTCGATCTGGCCATCGGTTTTGCCGGCAGTCACGCTGTCGAGATAGACAGCCAGCCGCTG
TTCGATGAACAACTGTGCCTGGTCATGGCCAAACCTGCCTCCGAGAAGCAGGCCGCGCTGACACTTGAGGACCTGCAAGC
GCTTCGCTTCGCCTTGCTGGCCCCCGGATTTGCCACTCGCCAGCTGCTGGATGCCTGGTGCCAGATGCAGAACTTCAAGC
CGATCATTGGCCTGGAAGCGAACTCGATTGCCATTTTGCTCAAGGTCGTCGCCCAGGGCCGCATGGCGACCATTCTTCCC
GATGCCATCGTTCGCAAGCAGCCCGGGTTGTGCGAAGTCCAGACGATCCCTGCCCTGCCTGGGCGAACGGTTGCGCTGCT
GCGGCGTAAAAACGGCTACCAGAGCGCCGCCGCCAAGGCTTTTGCAAAACTGGTGAGCGATATCAGAACAAAAATATGA

Upstream 100 bases:

>100_bases
TCCGGAATGAATTCACATCACTCACAGGATCGGCAACTATCACCATAAGATCCAAGACTGATTTATGATCATCGCCATAA
CCCTGACTTATGGTGATGCT

Downstream 100 bases:

>100_bases
ACCCGATGAGCAGACAATCAGAGCTGTTTTCAGCCGCGCACAAAAAAAGAGACCCGAAAGTCTCTTTTTTCATGACAGGC
CACTGACAGATCGTCACTTG

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLLRHIRYLLAVADHGNFTRAAEALHVSQPALSQQIRQLESSLGVQLFDRTRRSVVPTDAGRVYLDHARRCLLELDAGKR
ALNDVSDLSRGQLRLGVTPTFSEYLIAPLIDRFSALYPGVAIILTELPLEQITEALISDALDLAIGFAGSHAVEIDSQPL
FDEQLCLVMAKPASEKQAALTLEDLQALRFALLAPGFATRQLLDAWCQMQNFKPIIGLEANSIAILLKVVAQGRMATILP
DAIVRKQPGLCEVQTIPALPGRTVALLRRKNGYQSAAAKAFAKLVSDIRTKI

Sequences:

>Translated_292_residues
MLLRHIRYLLAVADHGNFTRAAEALHVSQPALSQQIRQLESSLGVQLFDRTRRSVVPTDAGRVYLDHARRCLLELDAGKR
ALNDVSDLSRGQLRLGVTPTFSEYLIAPLIDRFSALYPGVAIILTELPLEQITEALISDALDLAIGFAGSHAVEIDSQPL
FDEQLCLVMAKPASEKQAALTLEDLQALRFALLAPGFATRQLLDAWCQMQNFKPIIGLEANSIAILLKVVAQGRMATILP
DAIVRKQPGLCEVQTIPALPGRTVALLRRKNGYQSAAAKAFAKLVSDIRTKI
>Mature_292_residues
MLLRHIRYLLAVADHGNFTRAAEALHVSQPALSQQIRQLESSLGVQLFDRTRRSVVPTDAGRVYLDHARRCLLELDAGKR
ALNDVSDLSRGQLRLGVTPTFSEYLIAPLIDRFSALYPGVAIILTELPLEQITEALISDALDLAIGFAGSHAVEIDSQPL
FDEQLCLVMAKPASEKQAALTLEDLQALRFALLAPGFATRQLLDAWCQMQNFKPIIGLEANSIAILLKVVAQGRMATILP
DAIVRKQPGLCEVQTIPALPGRTVALLRRKNGYQSAAAKAFAKLVSDIRTKI

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=290, Percent_Identity=49.6551724137931, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1790399, Length=297, Percent_Identity=31.3131313131313, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=31.6, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788887, Length=292, Percent_Identity=31.5068493150685, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693105, Length=292, Percent_Identity=25.6849315068493, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788748, Length=295, Percent_Identity=29.4915254237288, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=30.7167235494881, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787601, Length=293, Percent_Identity=25.5972696245734, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1789204, Length=289, Percent_Identity=30.1038062283737, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87081904, Length=213, Percent_Identity=30.0469483568075, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=31.2883435582822, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789639, Length=144, Percent_Identity=32.6388888888889, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788481, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786401, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790208, Length=258, Percent_Identity=27.1317829457364, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787589, Length=302, Percent_Identity=25.8278145695364, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787806, Length=259, Percent_Identity=22.7799227799228, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786713, Length=168, Percent_Identity=30.952380952381, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082132, Length=260, Percent_Identity=25.7692307692308, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789506, Length=293, Percent_Identity=23.2081911262799, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788706, Length=172, Percent_Identity=31.9767441860465, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787949, Length=136, Percent_Identity=30.1470588235294, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31966; Mature: 31966

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYLLAVADHGNFTRAAEALHVSQPALSQQIRQLESSLGVQLFDRTRRSVVPTDA
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
GRVYLDHARRCLLELDAGKRALNDVSDLSRGQLRLGVTPTFSEYLIAPLIDRFSALYPGV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCH
AIILTELPLEQITEALISDALDLAIGFAGSHAVEIDSQPLFDEQLCLVMAKPASEKQAAL
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEECCCCCHHHHH
TLEDLQALRFALLAPGFATRQLLDAWCQMQNFKPIIGLEANSIAILLKVVAQGRMATILP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHH
DAIVRKQPGLCEVQTIPALPGRTVALLRRKNGYQSAAAKAFAKLVSDIRTKI
HHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLRHIRYLLAVADHGNFTRAAEALHVSQPALSQQIRQLESSLGVQLFDRTRRSVVPTDA
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
GRVYLDHARRCLLELDAGKRALNDVSDLSRGQLRLGVTPTFSEYLIAPLIDRFSALYPGV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCH
AIILTELPLEQITEALISDALDLAIGFAGSHAVEIDSQPLFDEQLCLVMAKPASEKQAAL
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEECCCCCHHHHH
TLEDLQALRFALLAPGFATRQLLDAWCQMQNFKPIIGLEANSIAILLKVVAQGRMATILP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHH
DAIVRKQPGLCEVQTIPALPGRTVALLRRKNGYQSAAAKAFAKLVSDIRTKI
HHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]