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The map label for this gene is hmgA [H]

Identifier: 66046555

GI number: 66046555

Start: 3977795

End: 3979099

Strand: Reverse

Name: hmgA [H]

Synonym: Psyr_3326

Alternate gene names: 66046555

Gene position: 3979099-3977795 (Counterclockwise)

Preceding gene: 66046557

Following gene: 66046554

Centisome position: 65.3

GC content: 60.46

Gene sequence:

>1305_bases
ATGGCTATCCACTCCAGTTCCGACGCATTGGTTTATCAGTCGGGCTTTGGCAACCAGTTCAGCAGCGAGGCGCTGCCCGA
CGCGCTGCCCGTTGGCCAGAATTCGCCGCAAAAGCATCCTCTGGGTCTGTATGCCGAGCAGTTTTCGGGCACCGCATTTA
CGGTCGCGCGCAGCGAAGCCCGACGTACCTGGCTGTATCGGATCAAGCCATCGGCAGCCCATTCGCGTTACCAGCGCATG
GATCGGCAGATGGCCGGTCAGGAGCCGGGGCCGATCAACCCCAACCGGTTGCGCTGGAATGCCTTCGATATCCCCGCGGC
ACCGACCGATTTCATTGACGGTCTCATCCCCCTCGCCAGCACCTCGGCGGCAGAGCAGGCTGAGGGTGTCAGCGTTTACC
TGTACACCGCCAACACCTCCATGCAGCGAGCGTTCTTTAGTGCGGATGGAGAATGGCTGGTGGTGCCGCAGCAGGGCCGA
CTCAGAATCGTCACCGAACTGGGCTTGCTGGACATCGAACCCCTGGAAATCGCCGTCTTGCCGCGAGGTTTGAAGTTCTG
CGTCCAACTGCTCGACAGCAGCGCCCGTGGGTACCTCTGCGAGAATCACGGTTGCGCCTTGCGCCTCCCGGAACTGGGCC
CGATCGGCAGCAACGGGCTGGCCAACTCACGTGATTTTCTGACCCCGGTTGCCTGGTTTGAAGACAGTCGCCAGCCGATG
CAACTGGTGCAGAAGTTCCTCGGTGAGCTGTGGTCGACGCAACTGGAGCACTCACCCTTTGACGTGGTGGGCTGGCACGG
CAACAACGTTCCGTACAAGTACGACCTGCGGCGTTTCAACACGATCGGTACGGTCAGCTACGATCACCCGGACCCATCGA
TTTTCACCGTACTCACCTCACCGGGGGCTATTCATGGCCAGGCTAATATCGATTTCGTGATCTTCCCGCCGCGCTGGATG
GTGGCGGAAAACACCTTCCGTCCGCCGTGGTTCCACCGCAACCTGATGAACGAATTCATGGGCCTGATCGACGGCGCGTA
CGACGCCAAGGCCGAAGGTTTCATGCCCGGTGGCGCTTCGCTGCACAACTGCATGAGTGCGCACGGCCCCGACAATGTTA
CCGCCGAAAAAGCCATTGCTGCCGAGCTGAAACCGCACAGGATCGACAACACCATGGCCTTCATGTTCGAAACCGGCAAG
GTATTGCGCCCCAGTCGTCACGCGCTCGACTGTCCGCAACTGCAAACCGATTACGATGCCTGCTGGAAGGATATGGCCAG
GACGTTCACCCAGGAGCCACGCTGA

Upstream 100 bases:

>100_bases
TGACCGGCTGGCAAACTCAAATTACGTTATGCGTAATCGCTTTACGTAAAATAATGTTTCGTCCTGTCTCTGCCCGACCC
CATGACAACAAGAGGTCCAG

Downstream 100 bases:

>100_bases
TGACTACCGCGCTCAATCGTCGTAGCTGGGTCGAATCTGCCAACGGGCATGCCGATTTCCCGCTGCAGAACCTGCCGTTG
GGCGTGTTCAGCCATGGCCA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEARRTWLYRIKPSAAHSRYQRM
DRQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLASTSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGR
LRIVTELGLLDIEPLEIAVLPRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPM
QLVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTSPGAIHGQANIDFVIFPPRWM
VAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGASLHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGK
VLRPSRHALDCPQLQTDYDACWKDMARTFTQEPR

Sequences:

>Translated_434_residues
MAIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEARRTWLYRIKPSAAHSRYQRM
DRQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLASTSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGR
LRIVTELGLLDIEPLEIAVLPRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPM
QLVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTSPGAIHGQANIDFVIFPPRWM
VAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGASLHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGK
VLRPSRHALDCPQLQTDYDACWKDMARTFTQEPR
>Mature_433_residues
AIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEARRTWLYRIKPSAAHSRYQRMD
RQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLASTSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGRL
RIVTELGLLDIEPLEIAVLPRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPMQ
LVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTSPGAIHGQANIDFVIFPPRWMV
AENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGASLHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGKV
LRPSRHALDCPQLQTDYDACWKDMARTFTQEPR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=437, Percent_Identity=47.5972540045767, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17507969, Length=435, Percent_Identity=49.6551724137931, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24583650, Length=430, Percent_Identity=49.3023255813954, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 48391; Mature: 48260

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEA
CCEECCCCEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEEHHCC
RRTWLYRIKPSAAHSRYQRMDRQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLAS
CCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
TSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGRLRIVTELGLLDIEPLEIAVL
CCHHHHCCCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCEEEEEECCCEECCCEEEEEC
PRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPM
CCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCHHCCHHHHHCCCCCHH
QLVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECEEEEEEECCCCCCEEEEEEC
PGAIHGQANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGAS
CCEEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
LHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGKVLRPSRHALDCPQLQTDYDA
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCHHH
CWKDMARTFTQEPR
HHHHHHHHHHCCCC
>Mature Secondary Structure 
AIHSSSDALVYQSGFGNQFSSEALPDALPVGQNSPQKHPLGLYAEQFSGTAFTVARSEA
CEECCCCEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEEHHCC
RRTWLYRIKPSAAHSRYQRMDRQMAGQEPGPINPNRLRWNAFDIPAAPTDFIDGLIPLAS
CCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
TSAAEQAEGVSVYLYTANTSMQRAFFSADGEWLVVPQQGRLRIVTELGLLDIEPLEIAVL
CCHHHHCCCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCEEEEEECCCEECCCEEEEEC
PRGLKFCVQLLDSSARGYLCENHGCALRLPELGPIGSNGLANSRDFLTPVAWFEDSRQPM
CCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCHHCCHHHHHCCCCCHH
QLVQKFLGELWSTQLEHSPFDVVGWHGNNVPYKYDLRRFNTIGTVSYDHPDPSIFTVLTS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECEEEEEEECCCCCCEEEEEEC
PGAIHGQANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGAS
CCEEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
LHNCMSAHGPDNVTAEKAIAAELKPHRIDNTMAFMFETGKVLRPSRHALDCPQLQTDYDA
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCHHH
CWKDMARTFTQEPR
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA