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The map label for this gene is 66046554

Identifier: 66046554

GI number: 66046554

Start: 3976500

End: 3977795

Strand: Reverse

Name: 66046554

Synonym: Psyr_3325

Alternate gene names: NA

Gene position: 3977795-3976500 (Counterclockwise)

Preceding gene: 66046555

Following gene: 66046552

Centisome position: 65.28

GC content: 61.96

Gene sequence:

>1296_bases
ATGACTACCGCGCTCAATCGTCGTAGCTGGGTCGAATCTGCCAACGGGCATGCCGATTTCCCGCTGCAGAACCTGCCGTT
GGGCGTGTTCAGCCATGGCCAGACCTGCCCGCGTGGCGGAGTGGCCATAGGCGACAGGATTTTCGATCTGCGCGCAGCAA
CAGAGGCCGGGGTGTTTCAGGCACCGGCCGCCGAGGTTGCCGAGGTTGCCAGCCGCGACCAGCTCAATGATTTTCTTGCA
CTGGGTGCCGCTGCCCGCCAGGCATTGCGCGCCGCCTTGTTGCAGTTGCTCGATGAAGACAGCCCGCAGCGCGACAGGCT
GCAGGGCGTTGCCGGTTTGTTGTTGCCGATGAGTGAGTGCACGTTGCACATGCCCGCTCGGGTGGGTGATTACTCGGACT
TCTACGTCGGTATTCATCACGCGCTGAATGTCGGCAAGCTGTTCCGCCCGGACAACCCGCTGCTGCCCAACTACAAATAC
GTGCCGATCGGCTATCACGGCAGAGCGTCGACCTTGTGTCCCTCGGGTACGGCTGTGCGGCGCCCCAGCGGACAAACCCT
GGCGGCAGGTCAGAACGCTCCTGCTTTCGGTCCCTGCCAACGCCTGGATTACGAACTGGAACTGGGGGTCTGGATCGGGC
CGGGGAATGCCCAGGGCGAGTCCATCGGGATCGATCGGGCCGCCGAGCATATTGCCGGGTTCTGCCTGCTCAACGATTGG
TCGGCGCGTGACATACAGGCATGGGAATACCAGCCGTTGGGACCGTTTCTGTCCAAGAGTTTTGCCACGACGATATCGCC
CTGGGTGGTGACTGCCGAAGCGCTTGAACCGTTTCGTCGTGCCCAACCGCCACGTCCGGACGGCGATCCGCAACCGCTGT
CGTATCTGCTCGATGACCACGATCAGCAGGGCGGGGCGCTGGATATCGAGCTGGAAGTGCTATTGCGGACTGCACAGATG
AAAGCCGACGGCCTGGCGCCTCACAGGCTGGGTCTGAGCAACTCGCTGAACATGTACTGGACAGTGGCGCAGATGGTTGC
GCATCACAGCGTTAACGGCTGCAAATTGCAGCCGGGTGACCTGCTCGGCACCGGTACGTTGTCCGGCCCCCAGGAAGGTC
AGTATGGCAGCCTGCTGGAGATGACCGCAGGCGGCAAACAACCGGTCACATTACCCAATGGCGAAGTGCGCATGTTCCTG
CAAAGTGGCGACGAAGTGATTCTGCGTGCCCGTTGTCATCGCGAAGGGCACGTCTCGATTGGCTTTGGTGAGTGCCGGGG
CGTTGTGCTGGACTGA

Upstream 100 bases:

>100_bases
TGCGCCCCAGTCGTCACGCGCTCGACTGTCCGCAACTGCAAACCGATTACGATGCCTGCTGGAAGGATATGGCCAGGACG
TTCACCCAGGAGCCACGCTG

Downstream 100 bases:

>100_bases
CCGCTTCAGCGTCAGCGGGTTATTTCGTACCAGCCGAGAAACATGTCCAGCGTCGACTCGACCACCGTGTGCTGCTCCTC
GGGGGTAAGCAATGCAGCAC

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTTALNRRSWVESANGHADFPLQNLPLGVFSHGQTCPRGGVAIGDRIFDLRAATEAGVFQAPAAEVAEVASRDQLNDFLA
LGAAARQALRAALLQLLDEDSPQRDRLQGVAGLLLPMSECTLHMPARVGDYSDFYVGIHHALNVGKLFRPDNPLLPNYKY
VPIGYHGRASTLCPSGTAVRRPSGQTLAAGQNAPAFGPCQRLDYELELGVWIGPGNAQGESIGIDRAAEHIAGFCLLNDW
SARDIQAWEYQPLGPFLSKSFATTISPWVVTAEALEPFRRAQPPRPDGDPQPLSYLLDDHDQQGGALDIELEVLLRTAQM
KADGLAPHRLGLSNSLNMYWTVAQMVAHHSVNGCKLQPGDLLGTGTLSGPQEGQYGSLLEMTAGGKQPVTLPNGEVRMFL
QSGDEVILRARCHREGHVSIGFGECRGVVLD

Sequences:

>Translated_431_residues
MTTALNRRSWVESANGHADFPLQNLPLGVFSHGQTCPRGGVAIGDRIFDLRAATEAGVFQAPAAEVAEVASRDQLNDFLA
LGAAARQALRAALLQLLDEDSPQRDRLQGVAGLLLPMSECTLHMPARVGDYSDFYVGIHHALNVGKLFRPDNPLLPNYKY
VPIGYHGRASTLCPSGTAVRRPSGQTLAAGQNAPAFGPCQRLDYELELGVWIGPGNAQGESIGIDRAAEHIAGFCLLNDW
SARDIQAWEYQPLGPFLSKSFATTISPWVVTAEALEPFRRAQPPRPDGDPQPLSYLLDDHDQQGGALDIELEVLLRTAQM
KADGLAPHRLGLSNSLNMYWTVAQMVAHHSVNGCKLQPGDLLGTGTLSGPQEGQYGSLLEMTAGGKQPVTLPNGEVRMFL
QSGDEVILRARCHREGHVSIGFGECRGVVLD
>Mature_430_residues
TTALNRRSWVESANGHADFPLQNLPLGVFSHGQTCPRGGVAIGDRIFDLRAATEAGVFQAPAAEVAEVASRDQLNDFLAL
GAAARQALRAALLQLLDEDSPQRDRLQGVAGLLLPMSECTLHMPARVGDYSDFYVGIHHALNVGKLFRPDNPLLPNYKYV
PIGYHGRASTLCPSGTAVRRPSGQTLAAGQNAPAFGPCQRLDYELELGVWIGPGNAQGESIGIDRAAEHIAGFCLLNDWS
ARDIQAWEYQPLGPFLSKSFATTISPWVVTAEALEPFRRAQPPRPDGDPQPLSYLLDDHDQQGGALDIELEVLLRTAQMK
ADGLAPHRLGLSNSLNMYWTVAQMVAHHSVNGCKLQPGDLLGTGTLSGPQEGQYGSLLEMTAGGKQPVTLPNGEVRMFLQ
SGDEVILRARCHREGHVSIGFGECRGVVLD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=417, Percent_Identity=47.0023980815348, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17568863, Length=419, Percent_Identity=48.4486873508353, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24657182, Length=417, Percent_Identity=45.8033573141487, Blast_Score=355, Evalue=5e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46493; Mature: 46362

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTALNRRSWVESANGHADFPLQNLPLGVFSHGQTCPRGGVAIGDRIFDLRAATEAGVFQ
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEHHHHCCCCCCC
APAAEVAEVASRDQLNDFLALGAAARQALRAALLQLLDEDSPQRDRLQGVAGLLLPMSEC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
TLHMPARVGDYSDFYVGIHHALNVGKLFRPDNPLLPNYKYVPIGYHGRASTLCPSGTAVR
CEECCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEEE
RPSGQTLAAGQNAPAFGPCQRLDYELELGVWIGPGNAQGESIGIDRAAEHIAGFCLLNDW
CCCCCEEECCCCCCCCCCHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHEEEEEECCC
SARDIQAWEYQPLGPFLSKSFATTISPWVVTAEALEPFRRAQPPRPDGDPQPLSYLLDDH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
DQQGGALDIELEVLLRTAQMKADGLAPHRLGLSNSLNMYWTVAQMVAHHSVNGCKLQPGD
CCCCCEEEEEHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCEECCCC
LLGTGTLSGPQEGQYGSLLEMTAGGKQPVTLPNGEVRMFLQSGDEVILRARCHREGHVSI
EEECCCCCCCCCCCCCCEEEECCCCCCCEECCCCCEEEEEECCCEEEEEEECCCCCCEEE
GFGECRGVVLD
EHHHCCCEECC
>Mature Secondary Structure 
TTALNRRSWVESANGHADFPLQNLPLGVFSHGQTCPRGGVAIGDRIFDLRAATEAGVFQ
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEHHHHCCCCCCC
APAAEVAEVASRDQLNDFLALGAAARQALRAALLQLLDEDSPQRDRLQGVAGLLLPMSEC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
TLHMPARVGDYSDFYVGIHHALNVGKLFRPDNPLLPNYKYVPIGYHGRASTLCPSGTAVR
CEECCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCCCCCCCCCCEEE
RPSGQTLAAGQNAPAFGPCQRLDYELELGVWIGPGNAQGESIGIDRAAEHIAGFCLLNDW
CCCCCEEECCCCCCCCCCHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHEEEEEECCC
SARDIQAWEYQPLGPFLSKSFATTISPWVVTAEALEPFRRAQPPRPDGDPQPLSYLLDDH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
DQQGGALDIELEVLLRTAQMKADGLAPHRLGLSNSLNMYWTVAQMVAHHSVNGCKLQPGD
CCCCCEEEEEHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCEECCCC
LLGTGTLSGPQEGQYGSLLEMTAGGKQPVTLPNGEVRMFLQSGDEVILRARCHREGHVSI
EEECCCCCCCCCCCCCCEEEECCCCCCCEECCCCCEEEEEECCCEEEEEEECCCCCCEEE
GFGECRGVVLD
EHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA