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The map label for this gene is iscS [H]

Identifier: 66046449

GI number: 66046449

Start: 3856593

End: 3857783

Strand: Reverse

Name: iscS [H]

Synonym: Psyr_3220

Alternate gene names: 66046449

Gene position: 3857783-3856593 (Counterclockwise)

Preceding gene: 66046463

Following gene: 66046448

Centisome position: 63.31

GC content: 62.22

Gene sequence:

>1191_bases
ATGAACGAGCCAGTGCTGTATTTTGATTACGCCGCCACCACGCCTGTGGACGAGCGCGTTATCAGCGTGATGGTCGATTG
CCTGGGGGCGTCAGGCAACTTCGGCAACCCTGCCTCCAGCTCCCATTCGTTCGGCCAAAAGGCCCGCCTTGCAGTGGAAC
TTGCCCGTGAGCAGGTTGCGCATCTGGTGGGTGCGCAAGCCTCGCAGATCATCTGGACTTCCGGCGCGACCGAGTCCAGC
AATCTGGCACTCAAGGGGGTGGCTCAGGAACGTGCCAAGCGGCAAGCCGCCGCCGGAGGCAGACCTGGTCATATCATCAC
CAGCCTGATCGAGCACAAGGCTACCCTCGACACTGCTCGTCAACTTGAGGAACAGGGCGTCGATGTCACCTGGCTGGCGC
CGGACAGCGAGGGTCTGATCAGTGCCGATGCAGTCAGTGCAGCCTTGCGTGACGATACCTTTCTGGTCTCGCTGATGCTG
GTCAATAACGAGCTGGGTACCGTCAACGACATCGCCGAAATCGGCAGGCGCGTACGTGGGCACGGGGCGCTGCTGCATGT
CGACGCTGCACAGGGCGCTGGCAAGCTGCCGATCGACCTCAGCCAGCTCGCGGTGGATTTGATGTCGCTCTCGGCACACA
AGATCTACGGGCCCAAAGGCATTGGCGCCTTGTATGTCGGCCCGCGTGCGCAGCAGCGTGTTCTCGCCCAGATTCACGGG
GGAGGGCACGAATGCGGCCTGCGCTCCGGGACGCTGGCGACGCATCAGATCGCCGGAATGGGCGCGGCTTTTGCCCTGGC
GGCAGAAGTGCTTGAAGAGGAGGCGGTTGAAATACAGCGCTTGAGCGATCTTCTTTGTGATCGCCTGGCCGAGATCCCCG
GCGTGTGTATAAACGGCAGTCCCACGCAGCGGATTGCCCACACACTCAGTTTTACTTTTACCCATAACGATCTGGACGTC
GCCGCGCTGGGTGAGAGCCTCGCCTTTTCGTCCACCTCCGCCTGCAACTCGGCGAAAAACCTGCCGTCGCATGTCCTGCT
CGCCCTGGGACTGAGCCCGCAGGCCGCCAGCCAGACCATACGCCTGAGTCTGGGGCGCTTCACTCGCGAGCAGGACATAG
CGCGCGCAGCTGACTTGATTCGCGCCTCTTTGATTGAGCCAGCGTTCTGGGCGGTTGCTCAGGCTCGGTGA

Upstream 100 bases:

>100_bases
ATATATTCTATTTTTGTCTATATAAATTCTAATTGATAATTTTTGGTTCTATTTGATTTCGTGCATGATCCTCTTCATGG
TCTGTGAACGAGGAACGCGC

Downstream 100 bases:

>100_bases
GTGCTCCATTATCTGAACCAATGAAAGCAGTCAATTTCCGGGTCAGCAGGAGAGTCAATGAGCACGCAATCCAATGCCAG
TTCAGACGTGGCAGAACGTT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNEPVLYFDYAATTPVDERVISVMVDCLGASGNFGNPASSSHSFGQKARLAVELAREQVAHLVGAQASQIIWTSGATESS
NLALKGVAQERAKRQAAAGGRPGHIITSLIEHKATLDTARQLEEQGVDVTWLAPDSEGLISADAVSAALRDDTFLVSLML
VNNELGTVNDIAEIGRRVRGHGALLHVDAAQGAGKLPIDLSQLAVDLMSLSAHKIYGPKGIGALYVGPRAQQRVLAQIHG
GGHECGLRSGTLATHQIAGMGAAFALAAEVLEEEAVEIQRLSDLLCDRLAEIPGVCINGSPTQRIAHTLSFTFTHNDLDV
AALGESLAFSSTSACNSAKNLPSHVLLALGLSPQAASQTIRLSLGRFTREQDIARAADLIRASLIEPAFWAVAQAR

Sequences:

>Translated_396_residues
MNEPVLYFDYAATTPVDERVISVMVDCLGASGNFGNPASSSHSFGQKARLAVELAREQVAHLVGAQASQIIWTSGATESS
NLALKGVAQERAKRQAAAGGRPGHIITSLIEHKATLDTARQLEEQGVDVTWLAPDSEGLISADAVSAALRDDTFLVSLML
VNNELGTVNDIAEIGRRVRGHGALLHVDAAQGAGKLPIDLSQLAVDLMSLSAHKIYGPKGIGALYVGPRAQQRVLAQIHG
GGHECGLRSGTLATHQIAGMGAAFALAAEVLEEEAVEIQRLSDLLCDRLAEIPGVCINGSPTQRIAHTLSFTFTHNDLDV
AALGESLAFSSTSACNSAKNLPSHVLLALGLSPQAASQTIRLSLGRFTREQDIARAADLIRASLIEPAFWAVAQAR
>Mature_396_residues
MNEPVLYFDYAATTPVDERVISVMVDCLGASGNFGNPASSSHSFGQKARLAVELAREQVAHLVGAQASQIIWTSGATESS
NLALKGVAQERAKRQAAAGGRPGHIITSLIEHKATLDTARQLEEQGVDVTWLAPDSEGLISADAVSAALRDDTFLVSLML
VNNELGTVNDIAEIGRRVRGHGALLHVDAAQGAGKLPIDLSQLAVDLMSLSAHKIYGPKGIGALYVGPRAQQRVLAQIHG
GGHECGLRSGTLATHQIAGMGAAFALAAEVLEEEAVEIQRLSDLLCDRLAEIPGVCINGSPTQRIAHTLSFTFTHNDLDV
AALGESLAFSSTSACNSAKNLPSHVLLALGLSPQAASQTIRLSLGRFTREQDIARAADLIRASLIEPAFWAVAQAR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=371, Percent_Identity=43.3962264150943, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI156713448, Length=407, Percent_Identity=33.6609336609337, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=51.9685039370079, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1789175, Length=308, Percent_Identity=30.8441558441558, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787970, Length=340, Percent_Identity=26.1764705882353, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=379, Percent_Identity=43.7994722955145, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319831, Length=375, Percent_Identity=42.9333333333333, Blast_Score=286, Evalue=5e-78,
Organism=Drosophila melanogaster, GI20129463, Length=376, Percent_Identity=42.5531914893617, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41679; Mature: 41679

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPVLYFDYAATTPVDERVISVMVDCLGASGNFGNPASSSHSFGQKARLAVELAREQVA
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
HLVGAQASQIIWTSGATESSNLALKGVAQERAKRQAAAGGRPGHIITSLIEHKATLDTAR
HHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QLEEQGVDVTWLAPDSEGLISADAVSAALRDDTFLVSLMLVNNELGTVNDIAEIGRRVRG
HHHHCCCCEEEECCCCCCCEEHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
HGALLHVDAAQGAGKLPIDLSQLAVDLMSLSAHKIYGPKGIGALYVGPRAQQRVLAQIHG
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCC
GGHECGLRSGTLATHQIAGMGAAFALAAEVLEEEAVEIQRLSDLLCDRLAEIPGVCINGS
CCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
PTQRIAHTLSFTFTHNDLDVAALGESLAFSSTSACNSAKNLPSHVLLALGLSPQAASQTI
HHHHHHHHEEEEEECCCCCHHHHCCHHHCCCCHHHHHHHCCCHHHHEEECCCCHHHHHHH
RLSLGRFTREQDIARAADLIRASLIEPAFWAVAQAR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MNEPVLYFDYAATTPVDERVISVMVDCLGASGNFGNPASSSHSFGQKARLAVELAREQVA
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
HLVGAQASQIIWTSGATESSNLALKGVAQERAKRQAAAGGRPGHIITSLIEHKATLDTAR
HHHCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QLEEQGVDVTWLAPDSEGLISADAVSAALRDDTFLVSLMLVNNELGTVNDIAEIGRRVRG
HHHHCCCCEEEECCCCCCCEEHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
HGALLHVDAAQGAGKLPIDLSQLAVDLMSLSAHKIYGPKGIGALYVGPRAQQRVLAQIHG
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCC
GGHECGLRSGTLATHQIAGMGAAFALAAEVLEEEAVEIQRLSDLLCDRLAEIPGVCINGS
CCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
PTQRIAHTLSFTFTHNDLDVAALGESLAFSSTSACNSAKNLPSHVLLALGLSPQAASQTI
HHHHHHHHEEEEEECCCCCHHHHCCHHHCCCCHHHHHHHCCCHHHHEEECCCCHHHHHHH
RLSLGRFTREQDIARAADLIRASLIEPAFWAVAQAR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA