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The map label for this gene is pepQ [H]

Identifier: 66046448

GI number: 66046448

Start: 3854727

End: 3856535

Strand: Reverse

Name: pepQ [H]

Synonym: Psyr_3219

Alternate gene names: 66046448

Gene position: 3856535-3854727 (Counterclockwise)

Preceding gene: 66046449

Following gene: 66046443

Centisome position: 63.29

GC content: 61.8

Gene sequence:

>1809_bases
ATGAGCACGCAATCCAATGCCAGTTCAGACGTGGCAGAACGTTTGGCGCAAACCCGCGCCTTGATGAGCAGGGAGCGCAT
CGATGCCTATCTGGTGCCGTCAGCGGATCCGCACCTCTCCGAATACCTGCCCGGCTATTGGCAGGGGCGCCAGTGGCTGT
CGGGTTTTCACGGCTCGGTCGGTACACTGATCATCACCCAGGATTTTGCCGGCATATGGGCTGACAGCCGCTACTGGGAA
CAGGCCACCAAAGAGCTGGCCGGCAGTGGCATCGAGCTGGTGAAACTGGTGCCCGGCCAGCAAGGTCCGCTCGAATGGCT
GGCAGACGAGGCCAAGGCCGAGAGCGTGGTGGCCGTTGATGGGGCGGTTCTCGCCGTTGCTTCTTCGCGAACCCTGGCAA
GCAAGCTCTATGAACGTGGCGCGCGGCTGCGAACCGACATCGACCTGCTCACCGAGCTGTGGCAGGACCGCCCCGCGTTG
CCGTCTCACCCGATTTACGAGCATTTGCCTCCCCAGGCGTCACTGGACCGTAGCGCAAAACTTGCGCGGGTTCGTCAGAT
CATCGCCGAGCGAAAGGCTGACTGGCACTTCATTGCAACGCTGGACGACATCGCCTGGCTGTTCAATCTGCGTGGCGCAG
ACGTTTCCTACAATCCGGTGTTCATCGCATTTGCCTTGATCGGTCCGCAAAGCGTCACGCTGTTCGTGGACTCGAAGAAA
GTGCCGGACCCGGTACGTGCGCGCCTGGAGCGCGACGGCATCAACCTCATGGAGTACACGCAGATTGGCGCCGCCTTGCG
CGAGCTGCCGAAGGATGCGCGACTGCTGGTCGATCCGGCCCGGGTTACCTGCGGGCTGCTCGATTACCTGGACAGCGAGG
TCACGCTGGTTGAAGGGCTTAACCCGAGCACGTTACTGAAGTCGCAAAAAACCGAAGCTGATACGGCCCACATCCGTCAG
GCAATGGAGCAGGACGGCGCAGCGCTTTGCGAGTTCTTCGCCTGGCTGGACAGTGCGCTGGGGCGAGAGCCTGTCAGCGA
ACTGACCATCGATGAAAAGCTCACTCAGGCACGCGAGCGGCGTCCGGGCTATGTCTCGCCGAGCTTTGCCACCATTGCGG
GCTTCAACGCCAATGGCGCGATGCCACATTACCGCGCGACCGAGGCGGAGCATGCACGGATAGAAGGTGATGGTCTGCTG
CTGATCGATTCGGGCGGCCAGTACCTTGGTGGTACCACCGACATCACGCGCATGGTGGCGATCGGAACACCGAGTGCCGA
ACAGAAGCAGGACTGTACGCGCGTCCTCAAGGGTGTGATCGCGCTGTCGCGTGCTCATTTTCCCAAGGGCATTCTGTCGC
CGCTGCTGGACGCAATTGCCCGAGCGCCTATCTGGAGTGAGGGTGTCAATTACGGCCACGGCACCGGGCATGGTGTGGGG
TATTTCCTGAATGTGCACGAGGGGCCGCAGGTCATTGCCTATCAGGCGCCGGCAACGCCGCAGACGGCCATGCTGCCGGG
CATGATCACGTCCATCGAGCCGGGTACGTACCGTCCTGGACGCTGGGGGGTGCGTATCGAAAACCTGGTGATCAACCAGG
AAGCCGGCAAAACCGAGTTCGGCGAGTTTCTGCGCTTTGAAACTCTGACGCTGTGCCCGATCGACACCCGTTGCCTCGAG
GTGTCGATGTTGAACGCAGAAGAGCGCGCCTGGCTGAACGACTACCATGTGCAGGTTCTGAAGCGGTTGAGCCCACTGCT
GCAGGGCACTGCGCTGTTGTGGCTGCAGGCCCGCACGATCCCCGTCTGA

Upstream 100 bases:

>100_bases
TTTGATTGAGCCAGCGTTCTGGGCGGTTGCTCAGGCTCGGTGAGTGCTCCATTATCTGAACCAATGAAAGCAGTCAATTT
CCGGGTCAGCAGGAGAGTCA

Downstream 100 bases:

>100_bases
TCAAGGCTCTGCGTTGCCGCGGGCTTAGTCCTGCGGCGACGGATCGGCCAGAGGTGCAGCTTTCCTGCACACGATGATCA
TGCTGCGGCTGGTGTAGCCC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MSTQSNASSDVAERLAQTRALMSRERIDAYLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIITQDFAGIWADSRYWE
QATKELAGSGIELVKLVPGQQGPLEWLADEAKAESVVAVDGAVLAVASSRTLASKLYERGARLRTDIDLLTELWQDRPAL
PSHPIYEHLPPQASLDRSAKLARVRQIIAERKADWHFIATLDDIAWLFNLRGADVSYNPVFIAFALIGPQSVTLFVDSKK
VPDPVRARLERDGINLMEYTQIGAALRELPKDARLLVDPARVTCGLLDYLDSEVTLVEGLNPSTLLKSQKTEADTAHIRQ
AMEQDGAALCEFFAWLDSALGREPVSELTIDEKLTQARERRPGYVSPSFATIAGFNANGAMPHYRATEAEHARIEGDGLL
LIDSGGQYLGGTTDITRMVAIGTPSAEQKQDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWSEGVNYGHGTGHGVG
YFLNVHEGPQVIAYQAPATPQTAMLPGMITSIEPGTYRPGRWGVRIENLVINQEAGKTEFGEFLRFETLTLCPIDTRCLE
VSMLNAEERAWLNDYHVQVLKRLSPLLQGTALLWLQARTIPV

Sequences:

>Translated_602_residues
MSTQSNASSDVAERLAQTRALMSRERIDAYLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIITQDFAGIWADSRYWE
QATKELAGSGIELVKLVPGQQGPLEWLADEAKAESVVAVDGAVLAVASSRTLASKLYERGARLRTDIDLLTELWQDRPAL
PSHPIYEHLPPQASLDRSAKLARVRQIIAERKADWHFIATLDDIAWLFNLRGADVSYNPVFIAFALIGPQSVTLFVDSKK
VPDPVRARLERDGINLMEYTQIGAALRELPKDARLLVDPARVTCGLLDYLDSEVTLVEGLNPSTLLKSQKTEADTAHIRQ
AMEQDGAALCEFFAWLDSALGREPVSELTIDEKLTQARERRPGYVSPSFATIAGFNANGAMPHYRATEAEHARIEGDGLL
LIDSGGQYLGGTTDITRMVAIGTPSAEQKQDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWSEGVNYGHGTGHGVG
YFLNVHEGPQVIAYQAPATPQTAMLPGMITSIEPGTYRPGRWGVRIENLVINQEAGKTEFGEFLRFETLTLCPIDTRCLE
VSMLNAEERAWLNDYHVQVLKRLSPLLQGTALLWLQARTIPV
>Mature_601_residues
STQSNASSDVAERLAQTRALMSRERIDAYLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIITQDFAGIWADSRYWEQ
ATKELAGSGIELVKLVPGQQGPLEWLADEAKAESVVAVDGAVLAVASSRTLASKLYERGARLRTDIDLLTELWQDRPALP
SHPIYEHLPPQASLDRSAKLARVRQIIAERKADWHFIATLDDIAWLFNLRGADVSYNPVFIAFALIGPQSVTLFVDSKKV
PDPVRARLERDGINLMEYTQIGAALRELPKDARLLVDPARVTCGLLDYLDSEVTLVEGLNPSTLLKSQKTEADTAHIRQA
MEQDGAALCEFFAWLDSALGREPVSELTIDEKLTQARERRPGYVSPSFATIAGFNANGAMPHYRATEAEHARIEGDGLLL
IDSGGQYLGGTTDITRMVAIGTPSAEQKQDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWSEGVNYGHGTGHGVGY
FLNVHEGPQVIAYQAPATPQTAMLPGMITSIEPGTYRPGRWGVRIENLVINQEAGKTEFGEFLRFETLTLCPIDTRCLEV
SMLNAEERAWLNDYHVQVLKRLSPLLQGTALLWLQARTIPV

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=621, Percent_Identity=36.231884057971, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI93141226, Length=602, Percent_Identity=32.3920265780731, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI264681565, Length=621, Percent_Identity=34.9436392914654, Blast_Score=326, Evalue=3e-89,
Organism=Escherichia coli, GI1788728, Length=181, Percent_Identity=32.0441988950276, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=614, Percent_Identity=31.9218241042345, Blast_Score=317, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI25149105, Length=591, Percent_Identity=27.4111675126904, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322999, Length=658, Percent_Identity=30.2431610942249, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17137632, Length=609, Percent_Identity=33.8259441707718, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI161078230, Length=625, Percent_Identity=27.36, Blast_Score=246, Evalue=5e-65,
Organism=Drosophila melanogaster, GI21357287, Length=625, Percent_Identity=27.36, Blast_Score=246, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66265; Mature: 66134

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSNASSDVAERLAQTRALMSRERIDAYLVPSADPHLSEYLPGYWQGRQWLSGFHGSV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCHHCCHHHHHHCCCCC
GTLIITQDFAGIWADSRYWEQATKELAGSGIELVKLVPGQQGPLEWLADEAKAESVVAVD
EEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEC
GAVLAVASSRTLASKLYERGARLRTDIDLLTELWQDRPALPSHPIYEHLPPQASLDRSAK
CEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHH
LARVRQIIAERKADWHFIATLDDIAWLFNLRGADVSYNPVFIAFALIGPQSVTLFVDSKK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCC
VPDPVRARLERDGINLMEYTQIGAALRELPKDARLLVDPARVTCGLLDYLDSEVTLVEGL
CCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCEEEEECC
NPSTLLKSQKTEADTAHIRQAMEQDGAALCEFFAWLDSALGREPVSELTIDEKLTQARER
CHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
RPGYVSPSFATIAGFNANGAMPHYRATEAEHARIEGDGLLLIDSGGQYLGGTTDITRMVA
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCHHHHEEEE
IGTPSAEQKQDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWSEGVNYGHGTGHGVG
ECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
YFLNVHEGPQVIAYQAPATPQTAMLPGMITSIEPGTYRPGRWGVRIENLVINQEAGKTEF
EEEEECCCCEEEEEECCCCCCHHHCCCHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCHH
GEFLRFETLTLCPIDTRCLEVSMLNAEERAWLNDYHVQVLKRLSPLLQGTALLWLQARTI
HHHHHHCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
PV
CC
>Mature Secondary Structure 
STQSNASSDVAERLAQTRALMSRERIDAYLVPSADPHLSEYLPGYWQGRQWLSGFHGSV
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCHHCCHHHHHHCCCCC
GTLIITQDFAGIWADSRYWEQATKELAGSGIELVKLVPGQQGPLEWLADEAKAESVVAVD
EEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEC
GAVLAVASSRTLASKLYERGARLRTDIDLLTELWQDRPALPSHPIYEHLPPQASLDRSAK
CEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHH
LARVRQIIAERKADWHFIATLDDIAWLFNLRGADVSYNPVFIAFALIGPQSVTLFVDSKK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCC
VPDPVRARLERDGINLMEYTQIGAALRELPKDARLLVDPARVTCGLLDYLDSEVTLVEGL
CCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCEEEEECC
NPSTLLKSQKTEADTAHIRQAMEQDGAALCEFFAWLDSALGREPVSELTIDEKLTQARER
CHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
RPGYVSPSFATIAGFNANGAMPHYRATEAEHARIEGDGLLLIDSGGQYLGGTTDITRMVA
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCCEEEECCCCCCCCCCHHHHEEEE
IGTPSAEQKQDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWSEGVNYGHGTGHGVG
ECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
YFLNVHEGPQVIAYQAPATPQTAMLPGMITSIEPGTYRPGRWGVRIENLVINQEAGKTEF
EEEEECCCCEEEEEECCCCCCHHHCCCHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCHH
GEFLRFETLTLCPIDTRCLEVSMLNAEERAWLNDYHVQVLKRLSPLLQGTALLWLQARTI
HHHHHHCEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
PV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]