Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 66046219

GI number: 66046219

Start: 3579407

End: 3580939

Strand: Reverse

Name: zwf [H]

Synonym: Psyr_2988

Alternate gene names: 66046219

Gene position: 3580939-3579407 (Counterclockwise)

Preceding gene: 66046220

Following gene: 66046218

Centisome position: 58.76

GC content: 59.75

Gene sequence:

>1533_bases
ATGGGCCTGTCGCGTGGCAGTGCCGAGCAAAAAACCGAGGTAGCACCACCCACGACGCTGTTTCTGTTCGGTGCCCATGG
CGACCTGGTCAAGCGCCTGTTGATGCCGGCGCTTTACAACCTGTCACGCGACGGTCTGGTGGATGAAGGGCTGCATATCG
TCGGCGTCGATCACAATGCGATCAGCGATGCCGATTTTGCGAAAAAGCTCGAGAACTTCATTCGTGATGAAGCCGCCGGC
AAGGTTGCCGGCGGCGGCAAGGATCCGCTAGATCCTGCGTTGTGGAGCAAGCTGGCCGAGCGCATCAGTTACGTGCAGGG
CGACTTCCTCGACGATTCCACCTATCAGGACATCGCCAGCAAGATCGAGAGCACCGGCACCGCGAACGCGGTGTTTTATC
TGGCCACCGCGCCGCGGTTTTTCAGTGAGGTCGCCCAGCGCCTGGGCTCGTCAGGTTTGCTGCAGGAAACCGAAGAAGGG
TTTCGTCGTGTCGTGATCGAAAAGCCGTTCGGCTCCGATCTGGCCAGTGCGGTCGAGCTCAATGGCTGCCTGCTCAAGGT
CATGAGCGAGAAGCAGATTTATCGGATCGACCATTACCTGGGCAAGGAGACGGTGCAGAACATTCTTGTCAGCCGTTTCT
CCAATGGCCTGTTCGAGTCGTTCTGGAACAATCACTACATCGATCACGTTCAGATCACGGCTGCGGAAACCGTAGGCGTT
GAAACCCGTGGCAGCTTTTACGAGCACACCGGTGCCTTGCGTGACATGGTGCCCAATCACCTGTTCCAGCTGCTGGCGAT
GGTGGCGATGGAGCCGCCTGCCGCTTTCGGTGCCGATGCCGTTCGCGGTGAGAAAGCCAAGGTGGTCGGCGCGATCCGGC
CCTGGAGCCAGGAGGAAGCCCTGGCCAATTCGGTGCGTGGCCAGTACGCGAAGGGCGTGATGGGCGACAGGCAGGTCGTC
GGTTATCGTCAGGAAGATCGCGTGGAGCCGGACAGCAGCACCGAGACCTACGTTGCACTGAAGGTCATGGTCGACAACTG
GCGCTGGGTGGGTGTGCCGTTCTACCTGCGCACCGGCAAGCGTATGAGCGCACGCAGCACCGAAATCGCCATTTGCTTCA
AGCCTGCTCCGTACGCGCAGTTCCGCGATACCGAGGTCGACCGGCTCAAGCCCAACTACCTGCGGATCCAGATCCAGCCT
AACGAAGGCATGTGGTTCGACCTGTTTGCCAAGCGTCCAGGCCCGAAACTGGAGATGGAAGATATCGCGTTGGGCTTCGC
CTACAAGGATTTCTTCGAGATGCAGCCCTCTACCGGGTACGAAACCCTCATTTATGACTGCCTGACCGGTGATCAGACGC
TCTTCCAGCGTGCCGACAACATCGAGAACGGCTGGCGTGCCGTGCAGCCGTTCCTCGATGCCTGGGCCGCGCAGCCGCAA
GTGCAGCTTTACGAGGCTGGCAAGGATGGCCCGCAAGCGGGTGAAGAGCTGCTGAGTCGTGACGGTCGGGAATGGAGAGA
ATTGAATGTCTGA

Upstream 100 bases:

>100_bases
CCCTGTTTGCGCGTTTCCGTTCCCGCCAGACAAGCTCGTACGCAGACAAGATGCTGTCCGCCATGCGCTTTGGATTTGGT
GGCCACAAGGAACCCAAGTA

Downstream 100 bases:

>100_bases
ACTGCCTGTACAGTTCCTGTTGTCCGACATCGACGGCACGTTACTGCGCCGTGATCACAGCCTTAGCCAAGCCAATATCG
ACGCCGTCAAGCGCCTGCGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MGLSRGSAEQKTEVAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLVDEGLHIVGVDHNAISDADFAKKLENFIRDEAAG
KVAGGGKDPLDPALWSKLAERISYVQGDFLDDSTYQDIASKIESTGTANAVFYLATAPRFFSEVAQRLGSSGLLQETEEG
FRRVVIEKPFGSDLASAVELNGCLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNGLFESFWNNHYIDHVQITAAETVGV
ETRGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSQEEALANSVRGQYAKGVMGDRQVV
GYRQEDRVEPDSSTETYVALKVMVDNWRWVGVPFYLRTGKRMSARSTEIAICFKPAPYAQFRDTEVDRLKPNYLRIQIQP
NEGMWFDLFAKRPGPKLEMEDIALGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWAAQPQ
VQLYEAGKDGPQAGEELLSRDGREWRELNV

Sequences:

>Translated_510_residues
MGLSRGSAEQKTEVAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLVDEGLHIVGVDHNAISDADFAKKLENFIRDEAAG
KVAGGGKDPLDPALWSKLAERISYVQGDFLDDSTYQDIASKIESTGTANAVFYLATAPRFFSEVAQRLGSSGLLQETEEG
FRRVVIEKPFGSDLASAVELNGCLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNGLFESFWNNHYIDHVQITAAETVGV
ETRGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSQEEALANSVRGQYAKGVMGDRQVV
GYRQEDRVEPDSSTETYVALKVMVDNWRWVGVPFYLRTGKRMSARSTEIAICFKPAPYAQFRDTEVDRLKPNYLRIQIQP
NEGMWFDLFAKRPGPKLEMEDIALGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWAAQPQ
VQLYEAGKDGPQAGEELLSRDGREWRELNV
>Mature_509_residues
GLSRGSAEQKTEVAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLVDEGLHIVGVDHNAISDADFAKKLENFIRDEAAGK
VAGGGKDPLDPALWSKLAERISYVQGDFLDDSTYQDIASKIESTGTANAVFYLATAPRFFSEVAQRLGSSGLLQETEEGF
RRVVIEKPFGSDLASAVELNGCLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNGLFESFWNNHYIDHVQITAAETVGVE
TRGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSQEEALANSVRGQYAKGVMGDRQVVG
YRQEDRVEPDSSTETYVALKVMVDNWRWVGVPFYLRTGKRMSARSTEIAICFKPAPYAQFRDTEVDRLKPNYLRIQIQPN
EGMWFDLFAKRPGPKLEMEDIALGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWAAQPQV
QLYEAGKDGPQAGEELLSRDGREWRELNV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=496, Percent_Identity=34.8790322580645, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI108773793, Length=496, Percent_Identity=34.8790322580645, Blast_Score=279, Evalue=6e-75,
Organism=Homo sapiens, GI52145310, Length=392, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788158, Length=505, Percent_Identity=37.029702970297, Blast_Score=346, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17538218, Length=508, Percent_Identity=35.4330708661417, Blast_Score=281, Evalue=8e-76,
Organism=Saccharomyces cerevisiae, GI6324088, Length=498, Percent_Identity=33.1325301204819, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24643352, Length=486, Percent_Identity=32.3045267489712, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24643350, Length=486, Percent_Identity=32.3045267489712, Blast_Score=252, Evalue=5e-67,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=26.8595041322314, Blast_Score=183, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57058; Mature: 56927

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSRGSAEQKTEVAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLVDEGLHIVGVDHNA
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
ISDADFAKKLENFIRDEAAGKVAGGGKDPLDPALWSKLAERISYVQGDFLDDSTYQDIAS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KIESTGTANAVFYLATAPRFFSEVAQRLGSSGLLQETEEGFRRVVIEKPFGSDLASAVEL
HHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHH
NGCLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNGLFESFWNNHYIDHVQITAAETVGV
HHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCC
ETRGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSQEEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCHHHH
LANSVRGQYAKGVMGDRQVVGYRQEDRVEPDSSTETYVALKVMVDNWRWVGVPFYLRTGK
HHHHHHHHHHHCCCCCCHHCCCCHHCCCCCCCCCCEEEEEEEEECCCEEEECEEEEECCC
RMSARSTEIAICFKPAPYAQFRDTEVDRLKPNYLRIQIQPNEGMWFDLFAKRPGPKLEME
CCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEEEEECCCCCCCCHH
DIALGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWAAQPQ
HHHHHHHHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
VQLYEAGKDGPQAGEELLSRDGREWRELNV
EEEEECCCCCHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
GLSRGSAEQKTEVAPPTTLFLFGAHGDLVKRLLMPALYNLSRDGLVDEGLHIVGVDHNA
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
ISDADFAKKLENFIRDEAAGKVAGGGKDPLDPALWSKLAERISYVQGDFLDDSTYQDIAS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KIESTGTANAVFYLATAPRFFSEVAQRLGSSGLLQETEEGFRRVVIEKPFGSDLASAVEL
HHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHH
NGCLLKVMSEKQIYRIDHYLGKETVQNILVSRFSNGLFESFWNNHYIDHVQITAAETVGV
HHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCC
ETRGSFYEHTGALRDMVPNHLFQLLAMVAMEPPAAFGADAVRGEKAKVVGAIRPWSQEEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEECCCCCHHHH
LANSVRGQYAKGVMGDRQVVGYRQEDRVEPDSSTETYVALKVMVDNWRWVGVPFYLRTGK
HHHHHHHHHHHCCCCCCHHCCCCHHCCCCCCCCCCEEEEEEEEECCCEEEECEEEEECCC
RMSARSTEIAICFKPAPYAQFRDTEVDRLKPNYLRIQIQPNEGMWFDLFAKRPGPKLEME
CCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEEEEECCCCCCCCHH
DIALGFAYKDFFEMQPSTGYETLIYDCLTGDQTLFQRADNIENGWRAVQPFLDAWAAQPQ
HHHHHHHHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
VQLYEAGKDGPQAGEELLSRDGREWRELNV
EEEEECCCCCHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]