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The map label for this gene is yqeC [H]

Identifier: 66046220

GI number: 66046220

Start: 3580939

End: 3581913

Strand: Reverse

Name: yqeC [H]

Synonym: Psyr_2989

Alternate gene names: 66046220

Gene position: 3581913-3580939 (Counterclockwise)

Preceding gene: 66046222

Following gene: 66046219

Centisome position: 58.78

GC content: 61.03

Gene sequence:

>975_bases
ATGCAACTTGGGATTATTGGACTGGGCCGTATGGGCGGCAACATCGCACGCCGTCTGATGCTGAATGGTCACACGACTGT
GGTGTACGACCGTGATGAAGCATCGCGCAACGCCCTGGCCAATGACGGTTCGACTGCGGTCGCAGACCTGAAGGAACTGG
TCGGTGCGCTCGCCAGGCCCCGTGCTGTCTGGGTGATGCTCCCGGCCGGTGCGCCGACCGAAGAGACCATTCAGACCCTC
AGCCAGTTGCTCGACGCCGATGACGTGATCATCGATGGCGGGAATACCTTCTACAAGGACGACATCCGGCGCGCTCAGGA
ATTGACTGAAAAGGGCCTGCATTACGTCGATGTCGGCACATCAGGCGGCGTTTGGGGTCTCGAACGTGGCTACTGCATGA
TGATCGGAGGCGAGGCCGCCGTCGTCGAGCGCCTCGATCCGCTGTTCGCGACACTGGCTCCAGGCCTCGGCTCGATCGAG
CGCACCCGTGACCGCACCTCGACCGATGATCGTGCCGAACGTGGCTATATCCACTCCGGCCCTGCGGGTTCCGGGCATTT
CGTGAAGATGATCCACAACGGCATCGAATACGGAATGATGCAGGCGTTCGCCGAAGGCTTCGATCTTCTCAAGCAGAAAA
ACTCCGAACTCCTGCCGCCTGAGCAGCGTTTTGACCTGAACACGGCGGATATTGCCGAAGTCTGGCGTCGTGGCAGTGTG
GTGTCGTCCTGGCTGCTGGATCTGACCGCCGACGCCCTGGCCACCGACCCTCACCTGGATGCATTCTCCGGTTCGGTTGC
CGACAGCGGTGAAGGTCGCTGGACCATCGAAGCGGCCATCGAGCAGGCGGTTCCGGTTCCTGTGCTGTCCAGCGCCCTGT
TTGCGCGTTTCCGTTCCCGCCAGACAAGCTCGTACGCAGACAAGATGCTGTCCGCCATGCGCTTTGGATTTGGTGGCCAC
AAGGAACCCAAGTAA

Upstream 100 bases:

>100_bases
GAACCGACGTTCCGCCTCGCTTGACTAATCAGCATGCTCGCAACCGTCGATGCGCTGGACGGCAAACGAGGCACCTTTTT
ACGATTTAAGGAGCACCTTC

Downstream 100 bases:

>100_bases
TGGGCCTGTCGCGTGGCAGTGCCGAGCAAAAAACCGAGGTAGCACCACCCACGACGCTGTTTCTGTTCGGTGCCCATGGC
GACCTGGTCAAGCGCCTGTT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRDEASRNALANDGSTAVADLKELVGALARPRAVWVMLPAGAPTEETIQTL
SQLLDADDVIIDGGNTFYKDDIRRAQELTEKGLHYVDVGTSGGVWGLERGYCMMIGGEAAVVERLDPLFATLAPGLGSIE
RTRDRTSTDDRAERGYIHSGPAGSGHFVKMIHNGIEYGMMQAFAEGFDLLKQKNSELLPPEQRFDLNTADIAEVWRRGSV
VSSWLLDLTADALATDPHLDAFSGSVADSGEGRWTIEAAIEQAVPVPVLSSALFARFRSRQTSSYADKMLSAMRFGFGGH
KEPK

Sequences:

>Translated_324_residues
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRDEASRNALANDGSTAVADLKELVGALARPRAVWVMLPAGAPTEETIQTL
SQLLDADDVIIDGGNTFYKDDIRRAQELTEKGLHYVDVGTSGGVWGLERGYCMMIGGEAAVVERLDPLFATLAPGLGSIE
RTRDRTSTDDRAERGYIHSGPAGSGHFVKMIHNGIEYGMMQAFAEGFDLLKQKNSELLPPEQRFDLNTADIAEVWRRGSV
VSSWLLDLTADALATDPHLDAFSGSVADSGEGRWTIEAAIEQAVPVPVLSSALFARFRSRQTSSYADKMLSAMRFGFGGH
KEPK
>Mature_324_residues
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRDEASRNALANDGSTAVADLKELVGALARPRAVWVMLPAGAPTEETIQTL
SQLLDADDVIIDGGNTFYKDDIRRAQELTEKGLHYVDVGTSGGVWGLERGYCMMIGGEAAVVERLDPLFATLAPGLGSIE
RTRDRTSTDDRAERGYIHSGPAGSGHFVKMIHNGIEYGMMQAFAEGFDLLKQKNSELLPPEQRFDLNTADIAEVWRRGSV
VSSWLLDLTADALATDPHLDAFSGSVADSGEGRWTIEAAIEQAVPVPVLSSALFARFRSRQTSSYADKMLSAMRFGFGGH
KEPK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=333, Percent_Identity=32.7327327327327, Blast_Score=138, Evalue=9e-33,
Organism=Escherichia coli, GI1788341, Length=334, Percent_Identity=32.0359281437126, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17542558, Length=310, Percent_Identity=32.9032258064516, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=325, Percent_Identity=33.5384615384615, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=310, Percent_Identity=32.5806451612903, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24639279, Length=306, Percent_Identity=33.6601307189542, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35129; Mature: 35129

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRDEASRNALANDGSTAVADLKELVGALARP
CCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
RAVWVMLPAGAPTEETIQTLSQLLDADDVIIDGGNTFYKDDIRRAQELTEKGLHYVDVGT
CEEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGVWGLERGYCMMIGGEAAVVERLDPLFATLAPGLGSIERTRDRTSTDDRAERGYIHSG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHCCCEECC
PAGSGHFVKMIHNGIEYGMMQAFAEGFDLLKQKNSELLPPEQRFDLNTADIAEVWRRGSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCHH
VSSWLLDLTADALATDPHLDAFSGSVADSGEGRWTIEAAIEQAVPVPVLSSALFARFRSR
HHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHH
QTSSYADKMLSAMRFGFGGHKEPK
CHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLGIIGLGRMGGNIARRLMLNGHTTVVYDRDEASRNALANDGSTAVADLKELVGALARP
CCEEEEEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCC
RAVWVMLPAGAPTEETIQTLSQLLDADDVIIDGGNTFYKDDIRRAQELTEKGLHYVDVGT
CEEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGVWGLERGYCMMIGGEAAVVERLDPLFATLAPGLGSIERTRDRTSTDDRAERGYIHSG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHCCCEECC
PAGSGHFVKMIHNGIEYGMMQAFAEGFDLLKQKNSELLPPEQRFDLNTADIAEVWRRGSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHCCHH
VSSWLLDLTADALATDPHLDAFSGSVADSGEGRWTIEAAIEQAVPVPVLSSALFARFRSR
HHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHH
QTSSYADKMLSAMRFGFGGHKEPK
CHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]