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The map label for this gene is mdh [H]

Identifier: 66045978

GI number: 66045978

Start: 3328127

End: 3329281

Strand: Reverse

Name: mdh [H]

Synonym: Psyr_2742

Alternate gene names: 66045978

Gene position: 3329281-3328127 (Counterclockwise)

Preceding gene: 66045979

Following gene: 66045977

Centisome position: 54.63

GC content: 65.11

Gene sequence:

>1155_bases
ATGCACCGCAACGACTGGCACTACCCGACTTCCATCCGCGCAGGCGCAGGACGCGTCAACGAACTGGCCGACGCCTGCAG
GGTGACCGGCATACAACGTCCGCTGCTGATCACCGACAGCTTTCTCGGCAGCACCGATATGATCACCAGCGCCGTGGAGG
ACTGCCGCAATCAATTGGGCCACTGCGGCCTGTTTGACCGGGTCAAGGGCAACCCGACCGGCACCAACGTCGCCGAGGGG
CTGCACGCTTACAGAACCGGAGGCTACGACGGTGTGATTGCGTTTGGCGGCGGCTCGGCGCTGGACGCTGCCAAGGCAGT
CGCGCTGATGTCGGGCCAGACCCGCCCGTTATGGGATTTCGAAGACGTCAACGACAACCACCTGCGCGCCGATCCGGATG
GCATTGCGCCGGTGATTGCGCTGCCGACAACGGCCGGGACCGGCTCTGAAGTAGGGCGTGCGTCGGTGATTACCGATGAG
CAGGCGCAGGTCAAACGCACCATTCTGCACCTTCGCATGATGCCGCGCATCGCGATTCTGGATGCCACGCTGACGCTCGA
CCTGCCCAGGCACCTGACCGCCGCCACCGGCGCCGATGCCTTGACCCACTGCATGGAGTCCTGGTGTTCGCCGGCCTGGC
ACCCGATGGCCGAAGCGGTTTCGGTCAAGGGCATGCAGATGATCAAGGCGTTTTTACCGCGTGTCGTCGCCGACGGGCAG
GACCTGGAGGCGCGGCAGCAGATGCTGGTGGCCTCCAGCCTCGGCGCGGCCGCGTTTCAGCGCGGTCTGGGCGGCGTACA
CGCAATCGCGCAGAGCCTTGGGGCGCTCTACGACCAGCATCATGGCTTGCTGAACGCAATCCTGCTGCCCTACGTGCTGG
AGGCCAATCGCTCGGTGCTGCAGACGCAAATGGACGATCTGGCGGTTTACCTGCGGTTGCCGTCGCCCGGTTTCTCCGGG
GTGATGGACTGGCTGCTGACACTGCGCGAGCAGATCGGCATTCCACATACGCTGGGCGAGATCGGTATCGACGATCGCGA
CGCCGAGCGGGTCGGGCGGATGGCTTTCGCCGATGGCTGCTCGCACACCAACCCGATTCGCCATTCGGCGCAGGCCTACG
CGCAGATCTTCAGCCGTGCAGTGAGGGGCGAGTGA

Upstream 100 bases:

>100_bases
CGTCACCGGCCTGTTCATGATCGCTTTCGGTCTGCGCCTGCTGATCGGGTTGCTGCCTGCTGGCCTCACTCACTGAACTC
ACCTGTAAAGGAATACCTGA

Downstream 100 bases:

>100_bases
ACCATGGCTGTCCTGAACGAGGCGGGGATACAGCGTCTTGACCATGTCTGGCGCAGTTTCGTCGAGCAGGGTCGGATCGT
CGGTGGCGTGCTGTTGCTGG

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MHRNDWHYPTSIRAGAGRVNELADACRVTGIQRPLLITDSFLGSTDMITSAVEDCRNQLGHCGLFDRVKGNPTGTNVAEG
LHAYRTGGYDGVIAFGGGSALDAAKAVALMSGQTRPLWDFEDVNDNHLRADPDGIAPVIALPTTAGTGSEVGRASVITDE
QAQVKRTILHLRMMPRIAILDATLTLDLPRHLTAATGADALTHCMESWCSPAWHPMAEAVSVKGMQMIKAFLPRVVADGQ
DLEARQQMLVASSLGAAAFQRGLGGVHAIAQSLGALYDQHHGLLNAILLPYVLEANRSVLQTQMDDLAVYLRLPSPGFSG
VMDWLLTLREQIGIPHTLGEIGIDDRDAERVGRMAFADGCSHTNPIRHSAQAYAQIFSRAVRGE

Sequences:

>Translated_384_residues
MHRNDWHYPTSIRAGAGRVNELADACRVTGIQRPLLITDSFLGSTDMITSAVEDCRNQLGHCGLFDRVKGNPTGTNVAEG
LHAYRTGGYDGVIAFGGGSALDAAKAVALMSGQTRPLWDFEDVNDNHLRADPDGIAPVIALPTTAGTGSEVGRASVITDE
QAQVKRTILHLRMMPRIAILDATLTLDLPRHLTAATGADALTHCMESWCSPAWHPMAEAVSVKGMQMIKAFLPRVVADGQ
DLEARQQMLVASSLGAAAFQRGLGGVHAIAQSLGALYDQHHGLLNAILLPYVLEANRSVLQTQMDDLAVYLRLPSPGFSG
VMDWLLTLREQIGIPHTLGEIGIDDRDAERVGRMAFADGCSHTNPIRHSAQAYAQIFSRAVRGE
>Mature_384_residues
MHRNDWHYPTSIRAGAGRVNELADACRVTGIQRPLLITDSFLGSTDMITSAVEDCRNQLGHCGLFDRVKGNPTGTNVAEG
LHAYRTGGYDGVIAFGGGSALDAAKAVALMSGQTRPLWDFEDVNDNHLRADPDGIAPVIALPTTAGTGSEVGRASVITDE
QAQVKRTILHLRMMPRIAILDATLTLDLPRHLTAATGADALTHCMESWCSPAWHPMAEAVSVKGMQMIKAFLPRVVADGQ
DLEARQQMLVASSLGAAAFQRGLGGVHAIAQSLGALYDQHHGLLNAILLPYVLEANRSVLQTQMDDLAVYLRLPSPGFSG
VMDWLLTLREQIGIPHTLGEIGIDDRDAERVGRMAFADGCSHTNPIRHSAQAYAQIFSRAVRGE

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=280, Percent_Identity=27.5, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI48994951, Length=391, Percent_Identity=32.9923273657289, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=34.1269841269841, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=31.0160427807487, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787493, Length=397, Percent_Identity=29.9748110831234, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537053, Length=280, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=32.010582010582, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24657991, Length=279, Percent_Identity=25.4480286738351, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41300; Mature: 41300

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRNDWHYPTSIRAGAGRVNELADACRVTGIQRPLLITDSFLGSTDMITSAVEDCRNQLG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHC
HCGLFDRVKGNPTGTNVAEGLHAYRTGGYDGVIAFGGGSALDAAKAVALMSGQTRPLWDF
CCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCC
EDVNDNHLRADPDGIAPVIALPTTAGTGSEVGRASVITDEQAQVKRTILHLRMMPRIAIL
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEECCHHHHHHHHHHHHHHCCHHEEE
DATLTLDLPRHLTAATGADALTHCMESWCSPAWHPMAEAVSVKGMQMIKAFLPRVVADGQ
EHHEEECCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DLEARQQMLVASSLGAAAFQRGLGGVHAIAQSLGALYDQHHGLLNAILLPYVLEANRSVL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QTQMDDLAVYLRLPSPGFSGVMDWLLTLREQIGIPHTLGEIGIDDRDAERVGRMAFADGC
HHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCC
SHTNPIRHSAQAYAQIFSRAVRGE
CCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHRNDWHYPTSIRAGAGRVNELADACRVTGIQRPLLITDSFLGSTDMITSAVEDCRNQLG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHC
HCGLFDRVKGNPTGTNVAEGLHAYRTGGYDGVIAFGGGSALDAAKAVALMSGQTRPLWDF
CCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCC
EDVNDNHLRADPDGIAPVIALPTTAGTGSEVGRASVITDEQAQVKRTILHLRMMPRIAIL
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEECCHHHHHHHHHHHHHHCCHHEEE
DATLTLDLPRHLTAATGADALTHCMESWCSPAWHPMAEAVSVKGMQMIKAFLPRVVADGQ
EHHEEECCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DLEARQQMLVASSLGAAAFQRGLGGVHAIAQSLGALYDQHHGLLNAILLPYVLEANRSVL
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QTQMDDLAVYLRLPSPGFSGVMDWLLTLREQIGIPHTLGEIGIDDRDAERVGRMAFADGC
HHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHCCC
SHTNPIRHSAQAYAQIFSRAVRGE
CCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]