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The map label for this gene is yngE [H]

Identifier: 66045705

GI number: 66045705

Start: 2861651

End: 2863258

Strand: Reverse

Name: yngE [H]

Synonym: Psyr_2469

Alternate gene names: 66045705

Gene position: 2863258-2861651 (Counterclockwise)

Preceding gene: 66045706

Following gene: 66045704

Centisome position: 46.99

GC content: 63.18

Gene sequence:

>1608_bases
ATGACCATTCTGCAGACCCGAATCAACACCCGCTCGCCTGAATTCACCCTCAATCGCGACGCCCTGCTCAAGCAGGTCGA
AGCATTGCGCTCGCTGTTGAGCAACGTCCAGCAAGGAGGCGGCCCCAAAGCCCAGGAGCGCCACACCTCACGCGGCAAGT
TGCTGCCGCGCGAGCGTATCAACCGTTTGCTGGACACCGGTTCACCGTTTCTGGAAATCGGCCAACTGGCTGCACATGAG
GTATACGGCGAAGAGGTTCCGGCCGCTGGCGTGATCGCCGGAATCGGCCGGGTCGAGGGCGTCGAATGCATGATCATCGC
CAACGACGCCACGGTCAAAGGCGGCTCCTATTACCCGCTGACCGTAAAGAAGCATTTGCGCGCCCAGACCATCGCCCAGC
AGAACCGCCTGCCGTGCATCTATCTGGTGGATTCCGGCGGCGCCAACCTGCCGCGTCAGGATGAAGTGTTTCCCGACCGC
GAACATTTCGGGCGGATCTTCTTCAACCAGGCCAACATGAGCGCGCAAGGTATCGCCCAGATCGCGGTGGTCATGGGCTC
CTGTACCGCAGGTGGCGCGTACGTACCCGCCATGGCCGACGAGGCGATCATGGTCCGCCAGCAGGCCACGATCTTTCTGG
CCGGCCCGCCGCTGGTCAAAGCCGCAACCGGCGAAGTGGTCAGCGCCGAAGAACTGGGCGGTGCCGATGTGCACTGCCGC
ACGTCCGGTGTGGCCGACCACTATGCCGACAACGACGATCACGCGCTCGCGCTGGCGCGGCGCAGCATCGCCAATCTGAA
CTGGCGCAAGCAGGGCCAATTGAACACCGTCGCGCCCATTGCACCGCTGTACCCCGGCGATGACCTGTACGGCATCATCC
CCACCGACACGAAACAGCCATTCGATGTAAGGGAAATCATCGCGCGCCTGGTGGATGGCTCGGTACTCGACGAATTCAAG
GCCCTGTTCGGCACCACGCTGGTCTGTGGCTTCGCGCGTCTGCATGGTTACCCGATCGCGATCCTCGCCAACAACGGCAT
CCTGTTCGCCGAAGCGGCGCAGAAAGGTGCGCATTTCATCGAGCTGGCCTGCCAAAGGGGCATCCCCCTGCTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGCCAGAAGTATGAAGCGGGCGGCATCGCCAAGCATGGTGCCAAGCTGGTGACCGCC
GTGGCCTGCGCCAGGGTGCCGAAATTCACGGTGATCATCGGCGGCAGTTTTGGCGCGGGGAATTACGGCATGTGTGGCCG
CGCTTACGATCCGCGCTTTCTATGGATGTGGCCCAACGCGCGGATCGGCGTGATGGGCGGCGAGCAGGCGGCCGGCGTGC
TGGTGCAGGTCAAATGCGAGCAGGCCGAACGGGCCGGTCAGGCGTTCAGCGCCGAACAGCAGGCCGAGCTGAAACAGCCG
ATTCTCGATCAGTACGAGCATCAGGGCCATCCTTACTATTCCAGCGCCCGCCTGTGGGACGACGGAGTCATCGACCCGGC
GCAAACCCGCGACATTCTCGCGCTTGCCCTCTCCGCCTCGCTCAACGCGCCCATCGAACCTACCACCTTCGGCCTGTTCC
GAATGTGA

Upstream 100 bases:

>100_bases
GACGCCAAACTCTACGAGATCGGCGCAGGCACCAGTGAAATCCGGCGCATGCTCATCGGTCGCGAACTGTTCAACGAAAC
CCGTTGATCGGGGAGCCACC

Downstream 100 bases:

>100_bases
GCCGGGAAATGACCATGACTTCGACCTCATTCGCAACCATAGAGCTGATCAACGACCCACGTGGCTTTGCCACGCTGTGG
CTGAATCGATCGGACAAGAA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTILQTRINTRSPEFTLNRDALLKQVEALRSLLSNVQQGGGPKAQERHTSRGKLLPRERINRLLDTGSPFLEIGQLAAHE
VYGEEVPAAGVIAGIGRVEGVECMIIANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAQGIAQIAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEELGGADVHCR
TSGVADHYADNDDHALALARRSIANLNWRKQGQLNTVAPIAPLYPGDDLYGIIPTDTKQPFDVREIIARLVDGSVLDEFK
ALFGTTLVCGFARLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACARVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGGEQAAGVLVQVKCEQAERAGQAFSAEQQAELKQP
ILDQYEHQGHPYYSSARLWDDGVIDPAQTRDILALALSASLNAPIEPTTFGLFRM

Sequences:

>Translated_535_residues
MTILQTRINTRSPEFTLNRDALLKQVEALRSLLSNVQQGGGPKAQERHTSRGKLLPRERINRLLDTGSPFLEIGQLAAHE
VYGEEVPAAGVIAGIGRVEGVECMIIANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDR
EHFGRIFFNQANMSAQGIAQIAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEELGGADVHCR
TSGVADHYADNDDHALALARRSIANLNWRKQGQLNTVAPIAPLYPGDDLYGIIPTDTKQPFDVREIIARLVDGSVLDEFK
ALFGTTLVCGFARLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTA
VACARVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGGEQAAGVLVQVKCEQAERAGQAFSAEQQAELKQP
ILDQYEHQGHPYYSSARLWDDGVIDPAQTRDILALALSASLNAPIEPTTFGLFRM
>Mature_534_residues
TILQTRINTRSPEFTLNRDALLKQVEALRSLLSNVQQGGGPKAQERHTSRGKLLPRERINRLLDTGSPFLEIGQLAAHEV
YGEEVPAAGVIAGIGRVEGVECMIIANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDRE
HFGRIFFNQANMSAQGIAQIAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEELGGADVHCRT
SGVADHYADNDDHALALARRSIANLNWRKQGQLNTVAPIAPLYPGDDLYGIIPTDTKQPFDVREIIARLVDGSVLDEFKA
LFGTTLVCGFARLHGYPIAILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAV
ACARVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGGEQAAGVLVQVKCEQAERAGQAFSAEQQAELKQPI
LDQYEHQGHPYYSSARLWDDGVIDPAQTRDILALALSASLNAPIEPTTFGLFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=65.4784240150094, Blast_Score=721, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=512, Percent_Identity=31.4453125, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI295821216, Length=532, Percent_Identity=30.4511278195489, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=58.7412587412587, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=61.5384615384615, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=491, Percent_Identity=33.1975560081466, Blast_Score=228, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI25147362, Length=491, Percent_Identity=33.1975560081466, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.6098003629764, Blast_Score=743, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57734; Mature: 57603

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILQTRINTRSPEFTLNRDALLKQVEALRSLLSNVQQGGGPKAQERHTSRGKLLPRERI
CCEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHH
NRLLDTGSPFLEIGQLAAHEVYGEEVPAAGVIAGIGRVEGVECMIIANDATVKGGSYYPL
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCCEEEE
TVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAQGIAQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCHHHHHH
IAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEELGGADVHCR
HHHHHHCCCCCCEECCCCCCCCEEEEEEEEEEEECCCEEEECCCCEEEHHHCCCCCEEEE
TSGVADHYADNDDHALALARRSIANLNWRKQGQLNTVAPIAPLYPGDDLYGIIPTDTKQP
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
FDVREIIARLVDGSVLDEFKALFGTTLVCGFARLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACARVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIGVMGGEQAAGVLVQVKCEQAERAGQAFSAEQQAELKQP
CCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHH
ILDQYEHQGHPYYSSARLWDDGVIDPAQTRDILALALSASLNAPIEPTTFGLFRM
HHHHHHHCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECC
>Mature Secondary Structure 
TILQTRINTRSPEFTLNRDALLKQVEALRSLLSNVQQGGGPKAQERHTSRGKLLPRERI
CEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHH
NRLLDTGSPFLEIGQLAAHEVYGEEVPAAGVIAGIGRVEGVECMIIANDATVKGGSYYPL
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEECCCEECCCCEEEE
TVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDREHFGRIFFNQANMSAQGIAQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECCCCCHHHHHH
IAVVMGSCTAGGAYVPAMADEAIMVRQQATIFLAGPPLVKAATGEVVSAEELGGADVHCR
HHHHHHCCCCCCEECCCCCCCCEEEEEEEEEEEECCCEEEECCCCEEEHHHCCCCCEEEE
TSGVADHYADNDDHALALARRSIANLNWRKQGQLNTVAPIAPLYPGDDLYGIIPTDTKQP
CCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
FDVREIIARLVDGSVLDEFKALFGTTLVCGFARLHGYPIAILANNGILFAEAAQKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHCCCHHH
ELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVTAVACARVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAYDPRFLWMWPNARIGVMGGEQAAGVLVQVKCEQAERAGQAFSAEQQAELKQP
CCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHH
ILDQYEHQGHPYYSSARLWDDGVIDPAQTRDILALALSASLNAPIEPTTFGLFRM
HHHHHHHCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]