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The map label for this gene is mmgC [H]

Identifier: 66045706

GI number: 66045706

Start: 2863272

End: 2864435

Strand: Reverse

Name: mmgC [H]

Synonym: Psyr_2470

Alternate gene names: 66045706

Gene position: 2864435-2863272 (Counterclockwise)

Preceding gene: 66045707

Following gene: 66045705

Centisome position: 47.01

GC content: 61.86

Gene sequence:

>1164_bases
ATGAGTTACCCCAGCCTGAACTTCGCACTTGGCGAAACCATCGACATGCTGCGCGACCAGCTGCAATCCTTCGTCGCCGC
AGAGCTTGCCCCGCGCGCCGCGCAGATCGACAAGGACAACCTGTTCCCCGCCGACATGTGGCGCAAGTTCGGTGAAATGG
GCGTACTGGGGATCACTGTCAGCGAAGAGTACGGCGGCGCGGGCCTGGGTTATCTGGCGCACGTCGTGGCGATGGAAGAA
ATCAGCCGTGGCTCGGCATCCGTGGCGCTTTCCTATGGCGCCCATTCCAATCTGTGCGTGAACCAGATCAACCGCAATGG
CAGCCCGGCGCAAAAGGCCCGTTACCTGCCCAAGCTGATCAGCGGCGAACACGTTGGCGCGCTGGCCATGAGCGAACCCA
ATGCAGGCTCGGACGTGGTGTCGATGAAACTGCGCGCCGACAAGCGCGGTGATCGCTACGTGCTCAACGGCAGCAAGACC
TGGATCACCAACGGGCCGGATGCCGACACCTATGTGATCTACGCCAAGACCGACCTGGAAAAGGCAGCCCACGGCATCAG
TGCGTTCATCGTCGAACGCGACTGGAAAGGCTTCTCGCGGGGCAGCAAGTTCGACAAGCTGGGCATGCGCGGCTCCAACA
CCTGCGAACTGTTTTTCGATGATGTCGAGGTGCCCGAGGAGAACCTGCTGGGCATGCTGGATGGCGGAGTCAGAGTGCTG
ATGAGCGGCCTTGATTACGAACGCGTCGTACTCTCCGGCGGACCGACCGGGATCATGCAGGCGTGCATGGACGTGGTGGT
GCCCTACATTCACGACCGCAAGCAGTTCGGCCAGAGCATCGGCGAGTTTCAGCTGATACAGGGCAAGGTCGCAGACATGT
ACACCCAGCTCAATGCCAGCCGGGCCTACCTGTATGCGGTCGCCCAGGCTTGTGATCGCGGCGAGACCACTCGCAAGGAC
GCTGCGGGGGTGATCCTGTACAGCGCCGAGCGCGCCACGCAGATGGCGCTGGAGGCCATCCAGATTCTCGGCGGCAATGG
CTACATCAACGAGTTCCCGGCGGGCCGACTGTTGCGCGACGCCAAACTCTACGAGATCGGCGCAGGCACCAGTGAAATCC
GGCGCATGCTCATCGGTCGCGAACTGTTCAACGAAACCCGTTGA

Upstream 100 bases:

>100_bases
GTTAACGTAAAGGTCATAGCTGATAGACACTATAACCGCTTCCAGAAAGACGCGCCGTCCAAGAACAAAGCGCCACTCAA
GAACAAAAAAGGAAAGCCCC

Downstream 100 bases:

>100_bases
TCGGGGAGCCACCATGACCATTCTGCAGACCCGAATCAACACCCGCTCGCCTGAATTCACCCTCAATCGCGACGCCCTGC
TCAAGCAGGTCGAAGCATTG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSYPSLNFALGETIDMLRDQLQSFVAAELAPRAAQIDKDNLFPADMWRKFGEMGVLGITVSEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGSPAQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKT
WITNGPDADTYVIYAKTDLEKAAHGISAFIVERDWKGFSRGSKFDKLGMRGSNTCELFFDDVEVPEENLLGMLDGGVRVL
MSGLDYERVVLSGGPTGIMQACMDVVVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKD
AAGVILYSAERATQMALEAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR

Sequences:

>Translated_387_residues
MSYPSLNFALGETIDMLRDQLQSFVAAELAPRAAQIDKDNLFPADMWRKFGEMGVLGITVSEEYGGAGLGYLAHVVAMEE
ISRGSASVALSYGAHSNLCVNQINRNGSPAQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKT
WITNGPDADTYVIYAKTDLEKAAHGISAFIVERDWKGFSRGSKFDKLGMRGSNTCELFFDDVEVPEENLLGMLDGGVRVL
MSGLDYERVVLSGGPTGIMQACMDVVVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKD
AAGVILYSAERATQMALEAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR
>Mature_386_residues
SYPSLNFALGETIDMLRDQLQSFVAAELAPRAAQIDKDNLFPADMWRKFGEMGVLGITVSEEYGGAGLGYLAHVVAMEEI
SRGSASVALSYGAHSNLCVNQINRNGSPAQKARYLPKLISGEHVGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKTW
ITNGPDADTYVIYAKTDLEKAAHGISAFIVERDWKGFSRGSKFDKLGMRGSNTCELFFDDVEVPEENLLGMLDGGVRVLM
SGLDYERVVLSGGPTGIMQACMDVVVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNASRAYLYAVAQACDRGETTRKDA
AGVILYSAERATQMALEAIQILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.2666666666667, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=67.2514619883041, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=41.7989417989418, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=35.9673024523161, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI21361497, Length=374, Percent_Identity=37.1657754010695, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=33.7662337662338, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=33.7662337662338, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=32.171581769437, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=35.0649350649351, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=35.0649350649351, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI7656849, Length=366, Percent_Identity=31.6939890710383, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=30.6451612903226, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI7669494, Length=368, Percent_Identity=31.25, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=27.9373368146214, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=27.6762402088773, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87082384, Length=283, Percent_Identity=28.6219081272085, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081702, Length=327, Percent_Identity=24.4648318042813, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=382, Percent_Identity=64.3979057591623, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=34.9081364829396, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=35.1706036745407, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=33.0729166666667, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=33.8582677165354, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=32.0954907161804, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=35.1428571428571, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=37.8571428571429, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.989247311828, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.2452316076294, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=309, Percent_Identity=33.9805825242718, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=363, Percent_Identity=30.0275482093664, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.3636363636364, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=32.4817518248175, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.0813008130081, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=25.9786476868327, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=63.1168831168831, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=41.3793103448276, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=39.2572944297082, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=34.2175066312997, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=34.6354166666667, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=31.151832460733, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24652780, Length=318, Percent_Identity=21.3836477987421, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42275; Mature: 42143

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYPSLNFALGETIDMLRDQLQSFVAAELAPRAAQIDKDNLFPADMWRKFGEMGVLGITV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
SEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGSPAQKARYLPKLI
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKTWITNGPDADTYVIYAKTDLE
CCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEECCCCCCCEEEEEEECCHH
KAAHGISAFIVERDWKGFSRGSKFDKLGMRGSNTCELFFDDVEVPEENLLGMLDGGVRVL
HHHCCCEEEEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCHHHH
MSGLDYERVVLSGGPTGIMQACMDVVVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNAS
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCC
RAYLYAVAQACDRGETTRKDAAGVILYSAERATQMALEAIQILGGNGYINEFPAGRLLRD
HHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AKLYEIGAGTSEIRRMLIGRELFNETR
CCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYPSLNFALGETIDMLRDQLQSFVAAELAPRAAQIDKDNLFPADMWRKFGEMGVLGITV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
SEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQINRNGSPAQKARYLPKLI
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKTWITNGPDADTYVIYAKTDLE
CCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEECCCCCCCEEEEEEECCHH
KAAHGISAFIVERDWKGFSRGSKFDKLGMRGSNTCELFFDDVEVPEENLLGMLDGGVRVL
HHHCCCEEEEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCHHHH
MSGLDYERVVLSGGPTGIMQACMDVVVPYIHDRKQFGQSIGEFQLIQGKVADMYTQLNAS
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHCCC
RAYLYAVAQACDRGETTRKDAAGVILYSAERATQMALEAIQILGGNGYINEFPAGRLLRD
HHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
AKLYEIGAGTSEIRRMLIGRELFNETR
CCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]