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The map label for this gene is asd [H]

Identifier: 66045226

GI number: 66045226

Start: 2306109

End: 2307221

Strand: Direct

Name: asd [H]

Synonym: Psyr_1986

Alternate gene names: 66045226

Gene position: 2306109-2307221 (Clockwise)

Preceding gene: 66045225

Following gene: 66045227

Centisome position: 37.84

GC content: 62.08

Gene sequence:

>1113_bases
ATGAAACGTGTAGGTCTGATCGGTTGGCGTGGCATGGTCGGTTCCGTGCTCATGCAGCGGATGCGGGAAGAGCAGGACTT
CGATCTCATTGAGCCGGTGTTCTTCACTACTTCCAATGTCGGTGGCCAGGCGCCTTCGGTGGGCAAGGATGTTGCGCCCC
TGAAAGATGCCTACAGCATCGACGAGCTGAAAACCCTGGACGTGGTGCTGACCTGCCAGGGTGGCGACTACACCAATGAG
GTGTTCCCCAAGCTGCGCGAAGCGGGCTGGCAGGGTTACTGGATCGATGCGGCGTCCAGCCTGCGCATGCAGGATGATGC
GGTCATCGTGCTTGACCCGGTGAACCGCAAGGTCATCGACCAGCAACTGGACGCGGGCACCAAGAACTATATCGGTGGCA
ACTGCACCGTCAGCCTGATGCTGATGGGGCTGGGCGGCCTGTTCGATGCCGGTCTGGTCGAGTGGATGAACGTCATGACC
TATCAGGCGGCCTCCGGCGCCGGCGCGCAGAACATGCGTGAGCTGATCAGGCAGATGGGCGCGGTGCATGCTTCGGTGGC
CGATGATCTGGCCAACCCGGCCAGCGCCATTCTGGACATCGACCGCAAGGTGGCTGAAGCCATGCGCAGCGAGTCGTTCC
CTACCGAGAACTTCGGCGTACCGCTTGCGGGCAGCCTGATCCCGTGGATCGACAAGGCCCTGCCAAACGGCCAGAGCCGC
GAAGAGTGGAAAGGCCAGGCCGAGACCAACAAGATCCTCGGTCGCTTCAAGAGCCCGATCCCGGTGGACGGCATCTGCGT
GCGCATCGGCGCCATGCGTTGCCATAGCCAGGCGCTGACCATCAAGCTGAACAAGGATGTGCCGATTGCGGACATCGAAG
GTTTGATCAGCCAGCACAACCCGTGGGTCAAGCTGGTGCCGAACAACCGCGAAGCCAGCATGCACGAGCTGAGCCCGACC
GCCGTGACCGGCACCATGAGCATTCCGGTAGGGCGTCTGCGCAAACTCAACATGGGTTCGCAGTACCTGGGCGCTTTCAC
CGTGGGTGACCAGCTGTTGTGGGGCGCTGCGGAGCCGCTGCGTCGCATGCTGAGAATCCTGCTGGAGCGTTGA

Upstream 100 bases:

>100_bases
GCGGTAGTCGCCGCGCTGCGGAATCTGTAATCTCTCTGGCCCGCCGCCTGCTGTGTACGCGCAGAGCGGCGGTCCCACTT
TTATTCAAGGTGTAGTTGCG

Downstream 100 bases:

>100_bases
GGCTTCGGTTTCACAGCCAACCCGCTTCCTGAAAGGGAAGCGGGTTTTTTAATGGCTGATACTTTTGGTTGATCGCCCTT
TGTCCCTATATATGGGATTG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKRVGLIGWRGMVGSVLMQRMREEQDFDLIEPVFFTTSNVGGQAPSVGKDVAPLKDAYSIDELKTLDVVLTCQGGDYTNE
VFPKLREAGWQGYWIDAASSLRMQDDAVIVLDPVNRKVIDQQLDAGTKNYIGGNCTVSLMLMGLGGLFDAGLVEWMNVMT
YQAASGAGAQNMRELIRQMGAVHASVADDLANPASAILDIDRKVAEAMRSESFPTENFGVPLAGSLIPWIDKALPNGQSR
EEWKGQAETNKILGRFKSPIPVDGICVRIGAMRCHSQALTIKLNKDVPIADIEGLISQHNPWVKLVPNNREASMHELSPT
AVTGTMSIPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPLRRMLRILLER

Sequences:

>Translated_370_residues
MKRVGLIGWRGMVGSVLMQRMREEQDFDLIEPVFFTTSNVGGQAPSVGKDVAPLKDAYSIDELKTLDVVLTCQGGDYTNE
VFPKLREAGWQGYWIDAASSLRMQDDAVIVLDPVNRKVIDQQLDAGTKNYIGGNCTVSLMLMGLGGLFDAGLVEWMNVMT
YQAASGAGAQNMRELIRQMGAVHASVADDLANPASAILDIDRKVAEAMRSESFPTENFGVPLAGSLIPWIDKALPNGQSR
EEWKGQAETNKILGRFKSPIPVDGICVRIGAMRCHSQALTIKLNKDVPIADIEGLISQHNPWVKLVPNNREASMHELSPT
AVTGTMSIPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPLRRMLRILLER
>Mature_370_residues
MKRVGLIGWRGMVGSVLMQRMREEQDFDLIEPVFFTTSNVGGQAPSVGKDVAPLKDAYSIDELKTLDVVLTCQGGDYTNE
VFPKLREAGWQGYWIDAASSLRMQDDAVIVLDPVNRKVIDQQLDAGTKNYIGGNCTVSLMLMGLGGLFDAGLVEWMNVMT
YQAASGAGAQNMRELIRQMGAVHASVADDLANPASAILDIDRKVAEAMRSESFPTENFGVPLAGSLIPWIDKALPNGQSR
EEWKGQAETNKILGRFKSPIPVDGICVRIGAMRCHSQALTIKLNKDVPIADIEGLISQHNPWVKLVPNNREASMHELSPT
AVTGTMSIPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPLRRMLRILLER

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=367, Percent_Identity=69.4822888283379, Blast_Score=543, Evalue=1e-156,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40510; Mature: 40510

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVGLIGWRGMVGSVLMQRMREEQDFDLIEPVFFTTSNVGGQAPSVGKDVAPLKDAYSI
CCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCH
DELKTLDVVLTCQGGDYTNEVFPKLREAGWQGYWIDAASSLRMQDDAVIVLDPVNRKVID
HHHEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCCEEEECCCCHHHHH
QQLDAGTKNYIGGNCTVSLMLMGLGGLFDAGLVEWMNVMTYQAASGAGAQNMRELIRQMG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AVHASVADDLANPASAILDIDRKVAEAMRSESFPTENFGVPLAGSLIPWIDKALPNGQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
EEWKGQAETNKILGRFKSPIPVDGICVRIGAMRCHSQALTIKLNKDVPIADIEGLISQHN
HHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCC
PWVKLVPNNREASMHELSPTAVTGTMSIPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPL
CEEEECCCCCCCHHHHCCCCEEEEEEECCHHHHHCCCCCCHHHEEEECCCHHHHCCHHHH
RRMLRILLER
HHHHHHHHCC
>Mature Secondary Structure
MKRVGLIGWRGMVGSVLMQRMREEQDFDLIEPVFFTTSNVGGQAPSVGKDVAPLKDAYSI
CCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCH
DELKTLDVVLTCQGGDYTNEVFPKLREAGWQGYWIDAASSLRMQDDAVIVLDPVNRKVID
HHHEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCCEEEECCCCHHHHH
QQLDAGTKNYIGGNCTVSLMLMGLGGLFDAGLVEWMNVMTYQAASGAGAQNMRELIRQMG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AVHASVADDLANPASAILDIDRKVAEAMRSESFPTENFGVPLAGSLIPWIDKALPNGQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCH
EEWKGQAETNKILGRFKSPIPVDGICVRIGAMRCHSQALTIKLNKDVPIADIEGLISQHN
HHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCC
PWVKLVPNNREASMHELSPTAVTGTMSIPVGRLRKLNMGSQYLGAFTVGDQLLWGAAEPL
CEEEECCCCCCCHHHHCCCCEEEEEEECCHHHHHCCCCCCHHHEEEECCCHHHHCCHHHH
RRMLRILLER
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]