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The map label for this gene is cefD [H]

Identifier: 66045205

GI number: 66045205

Start: 2276273

End: 2277553

Strand: Reverse

Name: cefD [H]

Synonym: Psyr_1965

Alternate gene names: 66045205

Gene position: 2277553-2276273 (Counterclockwise)

Preceding gene: 66045206

Following gene: 66045204

Centisome position: 37.38

GC content: 63.39

Gene sequence:

>1281_bases
ATGACTGATCGCAGAACCTTCCTCAAACAGGCCGGGCTGCTCGCGGCAGCCCTGCCCCTGGGCTCCGGCCTTGCAACGGC
AGCCGTGACGCCAGCGACTCAGCCGGCCTCCACGGACAAATGGACGCGCCTGAAACAATTGTTCAATCAGGACCCGGATT
ACGTCCACCTCTCCAATTTTCTGGTCACCTCGCACCCTGCACCGGTTCGCCAGGCCATCGAACAGCATCGTGCGCATATC
GACCGTAATCCCGGTCTGGCCATGGACTGGGACCTGGGAGAGACCGAGCGCCGCGAACACGAGGTTCGCGTCTGGGCGGG
CAAGTACCTGAACGCCCAACCCGGCCAGATCGCCCTGACCGGCAGCACCACTGAAGGCCTGGCAATCATCTACGGCGGTC
TCCATGTGCGCCCGGATCAGGAGATTCTGACCACCGAACACGAGCACTCCTGCGTCCACGATATCCTCAAATTCCGTCAG
CAGCGCGACGGCACGCAGGTGCGCAAGATTCGCCTGTTCAAGGACCCGGCGACCGTCTCGGCCGATGAAATCATCGGCTC
CATCGCGCGCAGCATTCAGCCGAAGACGCGGGTGCTGGGCATGACCTGGGTGCAGTCCGGCAGCGGCGTGAAACTGCCCA
TCGCGGCCATCGGCGATCTGGTCGAGGAACACAATCGCAACCGTGACGACCAGGAGCGCATTCTCTACGTGGTCGACGGC
GTGCATGGCTTTGGCGTCGAGAACCTCGATTTCCCGGAGATGAAGTGCGACTTCTATGTCGCCGGCACCCACAAGTGGCT
GTTTGGCCCGCGCGGCACCGGCATCGTTTGCGCACGCTCGGAACAGGTCAAGGACCTCACGCCGCTGATCCCGACGTTCT
CGGAAGCCACCGGTTTCAGCACGATCATAACGCCCGGTGGCTACCACTCGTTCGAACACCGCTGGGCGTTGAACGAGGCC
TTCAAACTGCACCTGCAACTGGGCAAGGCCGATGTGCAGGCACGCATTCACCAGCTCAACAGTTACCTCAAGCAGCGCCT
CAAGGCTCAGCCCAATGTCGAGCTGGTGACGCCGATGGACCCTGCGCTGTCGGCGGGCTTCAGCTTCTTCCGGCTCAAGG
GCCAGTCGTGCGACGACGTGGCGGCCTGGCTGATGGAGCAGCGCATGGTCGTTGACGCGGTGAGTCGCGACGTCGGCCCG
GTGGTGCGCACCGCGCCAGGGCTGCTGAACAGCGAAGCCGAAATCGATCGTTTCATGACGCTGCTCGCCCGGCGCGCCTG
A

Upstream 100 bases:

>100_bases
TTCCTGCGCGTCTGGGAGCAGGTTCAGGCTGCTGCTCGTCCGGATATGAAGCACATGAATCTCTCAAACGCCGCTACCCG
ACCCTCAGGCGCAGACGCTC

Downstream 100 bases:

>100_bases
CACAAACTCACCGATTACCTGTTTTCCGTTTTCCATCGAGACCCGTCATGAAAAAAACATTGCTGCCCCTGTCCGCCCTG
CTCGGCCTGTTGCTATGCGG

Product: twin-arginine translocation pathway signal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTDRRTFLKQAGLLAAALPLGSGLATAAVTPATQPASTDKWTRLKQLFNQDPDYVHLSNFLVTSHPAPVRQAIEQHRAHI
DRNPGLAMDWDLGETERREHEVRVWAGKYLNAQPGQIALTGSTTEGLAIIYGGLHVRPDQEILTTEHEHSCVHDILKFRQ
QRDGTQVRKIRLFKDPATVSADEIIGSIARSIQPKTRVLGMTWVQSGSGVKLPIAAIGDLVEEHNRNRDDQERILYVVDG
VHGFGVENLDFPEMKCDFYVAGTHKWLFGPRGTGIVCARSEQVKDLTPLIPTFSEATGFSTIITPGGYHSFEHRWALNEA
FKLHLQLGKADVQARIHQLNSYLKQRLKAQPNVELVTPMDPALSAGFSFFRLKGQSCDDVAAWLMEQRMVVDAVSRDVGP
VVRTAPGLLNSEAEIDRFMTLLARRA

Sequences:

>Translated_426_residues
MTDRRTFLKQAGLLAAALPLGSGLATAAVTPATQPASTDKWTRLKQLFNQDPDYVHLSNFLVTSHPAPVRQAIEQHRAHI
DRNPGLAMDWDLGETERREHEVRVWAGKYLNAQPGQIALTGSTTEGLAIIYGGLHVRPDQEILTTEHEHSCVHDILKFRQ
QRDGTQVRKIRLFKDPATVSADEIIGSIARSIQPKTRVLGMTWVQSGSGVKLPIAAIGDLVEEHNRNRDDQERILYVVDG
VHGFGVENLDFPEMKCDFYVAGTHKWLFGPRGTGIVCARSEQVKDLTPLIPTFSEATGFSTIITPGGYHSFEHRWALNEA
FKLHLQLGKADVQARIHQLNSYLKQRLKAQPNVELVTPMDPALSAGFSFFRLKGQSCDDVAAWLMEQRMVVDAVSRDVGP
VVRTAPGLLNSEAEIDRFMTLLARRA
>Mature_425_residues
TDRRTFLKQAGLLAAALPLGSGLATAAVTPATQPASTDKWTRLKQLFNQDPDYVHLSNFLVTSHPAPVRQAIEQHRAHID
RNPGLAMDWDLGETERREHEVRVWAGKYLNAQPGQIALTGSTTEGLAIIYGGLHVRPDQEILTTEHEHSCVHDILKFRQQ
RDGTQVRKIRLFKDPATVSADEIIGSIARSIQPKTRVLGMTWVQSGSGVKLPIAAIGDLVEEHNRNRDDQERILYVVDGV
HGFGVENLDFPEMKCDFYVAGTHKWLFGPRGTGIVCARSEQVKDLTPLIPTFSEATGFSTIITPGGYHSFEHRWALNEAF
KLHLQLGKADVQARIHQLNSYLKQRLKAQPNVELVTPMDPALSAGFSFFRLKGQSCDDVAAWLMEQRMVVDAVSRDVGPV
VRTAPGLLNSEAEIDRFMTLLARRA

Specific function: Catalyzes the reversible isomerization between isopenicillin N and penicillin N [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787970, Length=353, Percent_Identity=24.3626062322946, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=349, Percent_Identity=22.6361031518625, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =5.1.1.17 [H]

Molecular weight: Translated: 47404; Mature: 47272

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRRTFLKQAGLLAAALPLGSGLATAAVTPATQPASTDKWTRLKQLFNQDPDYVHLSNF
CCCHHHHHHHHCHHHHHHCCCCCCHHHEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCE
LVTSHPAPVRQAIEQHRAHIDRNPGLAMDWDLGETERREHEVRVWAGKYLNAQPGQIALT
EEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCEEEEEECCCCCCCCCEEEEE
GSTTEGLAIIYGGLHVRPDQEILTTEHEHSCVHDILKFRQQRDGTQVRKIRLFKDPATVS
CCCCCCEEEEECCEEECCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
ADEIIGSIARSIQPKTRVLGMTWVQSGSGVKLPIAAIGDLVEEHNRNRDDQERILYVVDG
HHHHHHHHHHHCCCHHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCHHEEEEEEEC
VHGFGVENLDFPEMKCDFYVAGTHKWLFGPRGTGIVCARSEQVKDLTPLIPTFSEATGFS
CCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCEEEEECCCHHHHHHCCCCCCHHCCCCE
TIITPGGYHSFEHRWALNEAFKLHLQLGKADVQARIHQLNSYLKQRLKAQPNVELVTPMD
EEECCCCCCCCHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
PALSAGFSFFRLKGQSCDDVAAWLMEQRMVVDAVSRDVGPVVRTAPGLLNSEAEIDRFMT
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHH
LLARRA
HHHHCC
>Mature Secondary Structure 
TDRRTFLKQAGLLAAALPLGSGLATAAVTPATQPASTDKWTRLKQLFNQDPDYVHLSNF
CCHHHHHHHHCHHHHHHCCCCCCHHHEECCCCCCCCCHHHHHHHHHHCCCCCEEEECCE
LVTSHPAPVRQAIEQHRAHIDRNPGLAMDWDLGETERREHEVRVWAGKYLNAQPGQIALT
EEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCEEEEEECCCCCCCCCEEEEE
GSTTEGLAIIYGGLHVRPDQEILTTEHEHSCVHDILKFRQQRDGTQVRKIRLFKDPATVS
CCCCCCEEEEECCEEECCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
ADEIIGSIARSIQPKTRVLGMTWVQSGSGVKLPIAAIGDLVEEHNRNRDDQERILYVVDG
HHHHHHHHHHHCCCHHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCHHEEEEEEEC
VHGFGVENLDFPEMKCDFYVAGTHKWLFGPRGTGIVCARSEQVKDLTPLIPTFSEATGFS
CCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCEEEEECCCHHHHHHCCCCCCHHCCCCE
TIITPGGYHSFEHRWALNEAFKLHLQLGKADVQARIHQLNSYLKQRLKAQPNVELVTPMD
EEECCCCCCCCHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
PALSAGFSFFRLKGQSCDDVAAWLMEQRMVVDAVSRDVGPVVRTAPGLLNSEAEIDRFMT
HHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHH
LLARRA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1694525; 2804141 [H]