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The map label for this gene is ghrB [H]

Identifier: 66044296

GI number: 66044296

Start: 1178149

End: 1179123

Strand: Reverse

Name: ghrB [H]

Synonym: Psyr_1043

Alternate gene names: 66044296

Gene position: 1179123-1178149 (Counterclockwise)

Preceding gene: 66044297

Following gene: 66044294

Centisome position: 19.35

GC content: 62.46

Gene sequence:

>975_bases
ATGAAAAAAACCGTACTCGCCTTCAGCCGTGTTTCTCCTGAAATGGCCGAGCGCCTGGCGCAAGACTTCAACGTGATCGT
GCCCAACCCCAAGCAGGGTGATATCAACGCGCAGTTTGCAGAAGCCTTGCCTGAATCCCACGGCCTTATAGGCGCAGGCC
GCAAGCTGGGTCGCGAACAACTGCAGAGCGCCACAAAGCTGGAGGTGGTGTCCAGCATCTCGGTGGGCTACGACAACTAC
GACGTCGACTACCTGAGCGAGCGCGGCATTCTGCTGACCAACACGCCGGATGTACTGACCGAAAGCACCGCCGACCTGGG
CTTCTCGCTGATCATGAGCAGCGCCCGCCGAGTCGCCGAACTGGACGCCTATACCAAGGCCGGACAGTGGACGCGCAGCA
TCGAACCGCCGCACTTCGGCACCGATGTGCATGGCAAGACGCTGGGTATCGTCGGCATGGGCAACATCGGCGCAGCCATT
GCCCGCCGCGGGCGTCTGGGCTTCAACATGCCGATTCTGTACGCCGGCAACAGCCGCAAGACCCAACTCGAACAGGAACT
GGGCGCACAATTTCGCAGCCTGGACCAGTTGCTGGCCGAAGCGGATTTCGTCTGCCTGGTGGTACCGCTGAGCGAAAAGA
CCAAGCACTTGATCGGCCGCCGCGAACTGAGCCTGATGAAGCCCGGCGCAATCCTGGTCAACATCGCCCGCGGCCCGATC
GTCGATGAACCCGCCCTGATCGAAGCGCTGCAGAACGGCACCATTCGCGGCGCCGGTCTGGACGTCTACGAAAAAGAGCC
GCTGAGCGAATCGCCGCTGTTCCAGCTCAAGAACGCGGTGACCCTGCCGCACGTAGGCTCAGCCACCACCGAAACCCGCC
AGGCCATGGCCGACCGCGCCTACGGCAACCTGCGCAGTGCGCTGCTCGGTGAACGACCGCAGGATCTGGTCAACCCGCAG
GTGTGGAAAGGCTGA

Upstream 100 bases:

>100_bases
GTCATCGTACTGACATCGTACAACTGCAAAAAGCGGCTGCCAAAGAGCGGGGAGGAATGTTAGCGTGCTACTCATTCAAC
CGCTCGAGAGTGACTGCCCA

Downstream 100 bases:

>100_bases
GGCCACGCCTCTGCCGATCTGCAGGCAATGCACGATCACCACCGACTCAGGCCAGTTTGCCGCCGACCACGACGGCAACC
GGTCTGACCTTCCTGAACAC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKKTVLAFSRVSPEMAERLAQDFNVIVPNPKQGDINAQFAEALPESHGLIGAGRKLGREQLQSATKLEVVSSISVGYDNY
DVDYLSERGILLTNTPDVLTESTADLGFSLIMSSARRVAELDAYTKAGQWTRSIEPPHFGTDVHGKTLGIVGMGNIGAAI
ARRGRLGFNMPILYAGNSRKTQLEQELGAQFRSLDQLLAEADFVCLVVPLSEKTKHLIGRRELSLMKPGAILVNIARGPI
VDEPALIEALQNGTIRGAGLDVYEKEPLSESPLFQLKNAVTLPHVGSATTETRQAMADRAYGNLRSALLGERPQDLVNPQ
VWKG

Sequences:

>Translated_324_residues
MKKTVLAFSRVSPEMAERLAQDFNVIVPNPKQGDINAQFAEALPESHGLIGAGRKLGREQLQSATKLEVVSSISVGYDNY
DVDYLSERGILLTNTPDVLTESTADLGFSLIMSSARRVAELDAYTKAGQWTRSIEPPHFGTDVHGKTLGIVGMGNIGAAI
ARRGRLGFNMPILYAGNSRKTQLEQELGAQFRSLDQLLAEADFVCLVVPLSEKTKHLIGRRELSLMKPGAILVNIARGPI
VDEPALIEALQNGTIRGAGLDVYEKEPLSESPLFQLKNAVTLPHVGSATTETRQAMADRAYGNLRSALLGERPQDLVNPQ
VWKG
>Mature_324_residues
MKKTVLAFSRVSPEMAERLAQDFNVIVPNPKQGDINAQFAEALPESHGLIGAGRKLGREQLQSATKLEVVSSISVGYDNY
DVDYLSERGILLTNTPDVLTESTADLGFSLIMSSARRVAELDAYTKAGQWTRSIEPPHFGTDVHGKTLGIVGMGNIGAAI
ARRGRLGFNMPILYAGNSRKTQLEQELGAQFRSLDQLLAEADFVCLVVPLSEKTKHLIGRRELSLMKPGAILVNIARGPI
VDEPALIEALQNGTIRGAGLDVYEKEPLSESPLFQLKNAVTLPHVGSATTETRQAMADRAYGNLRSALLGERPQDLVNPQ
VWKG

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=251, Percent_Identity=40.2390438247012, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=32.3024054982818, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=35.1851851851852, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=35.1851851851852, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=35.4243542435424, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=35.4243542435424, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.1851851851852, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=49.3865030674847, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1789279, Length=274, Percent_Identity=31.7518248175182, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787645, Length=193, Percent_Identity=33.6787564766839, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=32.6388888888889, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788660, Length=108, Percent_Identity=37.037037037037, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=32.5657894736842, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=279, Percent_Identity=29.3906810035842, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=34.8360655737705, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=273, Percent_Identity=30.4029304029304, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=273, Percent_Identity=29.6703296703297, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321253, Length=319, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=184, Percent_Identity=31.5217391304348, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=252, Percent_Identity=25.3968253968254, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=35.9621451104101, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45552429, Length=280, Percent_Identity=37.8571428571429, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=38.9513108614232, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=38.9513108614232, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=38.9513108614232, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=38.9513108614232, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=37.3076923076923, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=34, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=33.210332103321, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=33.210332103321, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=33.210332103321, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=33.210332103321, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=33.210332103321, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI19921140, Length=240, Percent_Identity=31.6666666666667, Blast_Score=117, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35186; Mature: 35186

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTVLAFSRVSPEMAERLAQDFNVIVPNPKQGDINAQFAEALPESHGLIGAGRKLGREQ
CCCHHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHH
LQSATKLEVVSSISVGYDNYDVDYLSERGILLTNTPDVLTESTADLGFSLIMSSARRVAE
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
LDAYTKAGQWTRSIEPPHFGTDVHGKTLGIVGMGNIGAAIARRGRLGFNMPILYAGNSRK
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCH
TQLEQELGAQFRSLDQLLAEADFVCLVVPLSEKTKHLIGRRELSLMKPGAILVNIARGPI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VDEPALIEALQNGTIRGAGLDVYEKEPLSESPLFQLKNAVTLPHVGSATTETRQAMADRA
CCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGNLRSALLGERPQDLVNPQVWKG
HHHHHHHHHCCCCHHHCCCCCCCC
>Mature Secondary Structure
MKKTVLAFSRVSPEMAERLAQDFNVIVPNPKQGDINAQFAEALPESHGLIGAGRKLGREQ
CCCHHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHH
LQSATKLEVVSSISVGYDNYDVDYLSERGILLTNTPDVLTESTADLGFSLIMSSARRVAE
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHHH
LDAYTKAGQWTRSIEPPHFGTDVHGKTLGIVGMGNIGAAIARRGRLGFNMPILYAGNSRK
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCH
TQLEQELGAQFRSLDQLLAEADFVCLVVPLSEKTKHLIGRRELSLMKPGAILVNIARGPI
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VDEPALIEALQNGTIRGAGLDVYEKEPLSESPLFQLKNAVTLPHVGSATTETRQAMADRA
CCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGNLRSALLGERPQDLVNPQVWKG
HHHHHHHHHCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA