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The map label for this gene is hemH [H]

Identifier: 66044220

GI number: 66044220

Start: 1100499

End: 1101521

Strand: Direct

Name: hemH [H]

Synonym: Psyr_0967

Alternate gene names: 66044220

Gene position: 1100499-1101521 (Clockwise)

Preceding gene: 66044219

Following gene: 66044223

Centisome position: 18.06

GC content: 59.73

Gene sequence:

>1023_bases
ATGACCGATCACGCTTTGTTGCTGGTCAATCTGGGTTCGCCTGCCTCTACTCAAGTGGCAGACGTGCGCAGCTATCTGAA
CCAGTTCCTGATGGATCCTTATGTGATCGACCTGCCGTGGCCAGTGCGCAGGCTGTTGGTCTCGCTGATTCTGATCAAAC
GGCCAGAGCAGTCCGCACACGCCTATGCGTCCATCTGGTGGGATGAAGGTTCGCCTCTGGTGGTGCTGAGCAAGCGTCTG
CAGCAGGCGATGAAAAAAGAGTGGTCGCACGGGCCGGTCGAGCTGGCCATGCGTTATGGCGAGCCGTCCATCGAAACCGT
GCTGACGCGCCTGGCAGAGCAGGGCTTCAAGAAGGTCACCCTGGCGCCGCTGTATCCGCAGTTCGCCGACAGCACGGTGA
CCACGGTCATTGAAGAAGCCAAACGTGTGGTGCGCGCCAAATCGTTGAAGATGCAGTTCTCGGTGCTGCAGCCGTTCTAC
GATCAGCCCGAGTACCTGAGTGCGCTGGTGGAAAGCGTGCGGCCGCATCTGGAGCAGCCTTACGACCATTTGCTGCTGAG
CTTTCACGGTCTTCCCGAGCGGCACCTGCACAAGCTCGACCCGACCGGCAAGCATTGCCTGAAGGACGACTGCTGCATGA
CCGCCCCCGCCGAAGTGCTCGCCACCTGCTATCGCGCGCAGTGCATACAGTCGGCGGCGGCATTCGCCAAACGTATGGGC
ATTGCTGACGGCAAATGGTCGGTGTCGTTCCAGTCACGTCTGGGGCGTGCCAAGTGGATCGAACCCTACACCGAAGCGCA
TCTGGACGAACTGGCGGCGAAAGGTGTGAAGAAGCTGCTGGTCATGTGCCCGGCGTTCGTGGCTGATTGCATTGAAACGC
TGGAAGAGATCGGTGATCGCGGTGCCGAGCAGTTCAAGGAAGCGGGGGGAGAGGAACTGATTCTGATCCCTTGCCTGAAC
GACGACCCCAACTGGGCGAAAGAGTTGAACAGACTGTGCGAGCGTGCGCCGTTGATGTTGTAG

Upstream 100 bases:

>100_bases
GCAGGAAGCTGGTTTTACATTCAAGTACACCGAACTCGACACCGCCCTGCAGGATTTGCTGGGTCGCCACTGAACGCTGT
TGAAATGAATAGGATGTTGC

Downstream 100 bases:

>100_bases
TGCTGCGAACGCCAGGGTGGTGGTGATCGTTCCTACGCTCCGCGTAGGAATGCATTTCGTGACGCTCCGCGTCACAAATC
TGCGCTGCACCGCACATTCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRL
QQAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFY
DQPEYLSALVESVRPHLEQPYDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMG
IADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDRGAEQFKEAGGEELILIPCLN
DDPNWAKELNRLCERAPLML

Sequences:

>Translated_340_residues
MTDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRL
QQAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFY
DQPEYLSALVESVRPHLEQPYDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMG
IADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDRGAEQFKEAGGEELILIPCLN
DDPNWAKELNRLCERAPLML
>Mature_339_residues
TDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRLQ
QAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFYD
QPEYLSALVESVRPHLEQPYDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMGI
ADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDRGAEQFKEAGGEELILIPCLND
DPNWAKELNRLCERAPLML

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=37.8048780487805, Blast_Score=195, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324750, Length=321, Percent_Identity=25.2336448598131, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38324; Mature: 38193

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAH
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHH
AYASIWWDEGSPLVVLSKRLQQAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVT
HEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
LAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFYDQPEYLSALVESVRPHLEQP
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
YDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMG
HHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
IADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDR
CCCCCEEEEHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEQFKEAGGEELILIPCLNDDPNWAKELNRLCERAPLML
CHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAH
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHH
AYASIWWDEGSPLVVLSKRLQQAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVT
HEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
LAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFYDQPEYLSALVESVRPHLEQP
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
YDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMG
HHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
IADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDR
CCCCCEEEEHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEQFKEAGGEELILIPCLNDDPNWAKELNRLCERAPLML
CHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA