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The map label for this gene is mtrB [H]

Identifier: 62389643

GI number: 62389643

Start: 792985

End: 794484

Strand: Direct

Name: mtrB [H]

Synonym: cg0864

Alternate gene names: 62389643

Gene position: 792985-794484 (Clockwise)

Preceding gene: 62389642

Following gene: 62389644

Centisome position: 24.16

GC content: 56.67

Gene sequence:

>1500_bases
GTGCTCGGCTCCATCTTCACCGCATCAGCTGTCGTGATGATCCTTTTGGGGCTGGGCATGCTGACTGTATTCACCCAACG
GTTGGTGGATCAGAAAATCGATATTGCGAGCTCCGAAATCGACCGCGCCCGCGTCATCGTCGAAGAGCAAATCACCGCAT
CCGGCGCCTCAACATCGGTGCAGGCGCGAGTGAACTCTGCCCGCGCTGCGCTCTCCAGCTTGGGTACCAGCGGCGGTACA
GAAACCAACGCCGCCTACGATCCAGTCGTGTTGGTGAACAACGATGACCTGGTGGTCTCTCCCGAGGGTTACCAAATCCC
AGAACGTCTGCGATACTTCGTCTCTGAGAACCAAGTCTCGTATCAGTTCTCCAGCATCGACCAAGGCGACGGATCGTCCT
ACCAAGCGCTCATCATCGGAACGCCCACGGAAAGCGACATCCCGAACCTCCAGGTGTATCTGGTGTTCTCCATGGAAAGC
GACGAATCCTCTCTTGCTCTCATGCGAGGACTCCTCTCAGCTGCACTGCTGATCGTGGTGGTGCTGCTGGTCGGTATCGC
ATGGCTAGCCACCCAACAGGTCACCGCGCCGGTGCGTTCGGCGAGCCGGATTGCGGAGCGTTTCGCTCAAGGCAAACTGC
GTGAACGCATGGTGGTGGAAGGCGAAGACGAGATGGCCCGCCTGGCGGTGTCCTTCAACGCGATGGCCGAATCGCTGTCC
GCGCAGATCACCAAATTGGAGGAATACGGCAATCTGCAACGACAATTCACATCGGATGTCTCACACGAATTGCGCACACC
GCTGACAACGGTGCGCATGGCTGCTGATCTAATTGCCGATAGTGAAGATGAACTTTCACCCGGTGCGCGCCGCGCCAGCC
AACTGATGAACAGGGAGTTGGACCGATTCGAGTCGCTGCTGAGCGATCTGTTGGAAATTTCCCGACACGACGCCGGCGTT
GCCGAACTGTCCACCGCGCTTCACGATGTCCGCATCCCAGTGCGATCGGCATTGGAACAAGTACAACACTTGGCCACCGA
GCTCGATGTGGAATTGCTTGTTAATTTGCCCGAAGAAGCGATCAACATTCAAGGCGATTCCAGGCGCATCGAAAGAATCA
TTCGCAACCTTCTAGCCAATGCGATCGACCACTCCAAGGGCTTGCCTGTTGAGTTGAAAGTTGCCGACAACGTGGACGCA
GTAGCGATCGTTGTTATTGATCACGGCGTCGGCCTGAAACCTGGACAAGACGAATTGGTGTTCAACAGATTCTGGCGAGC
CGACCCTTCGCGCGTCCGCCATTCTGGTGGCACCGGCCTGGGTCTTGCGATTTCTCGCGAAGATGCGATGCTTCATGGAG
GAAACCTTGATGCGGCGGGAACGATCGGTGTTGGTTCCATTTTCCGTTTGGTCTTGCCTAAAGAACCGCATGGAAATTAT
CGTGAAGCACCGATCCCGTTGATCGCTCCAGAGACACCGTGGGAAGGGGAGCAGCAGTGA

Upstream 100 bases:

>100_bases
AGTTTTTCATTTAAAAAAGGGGCAGTTTCTCATTCTTGCCTGGCTCACGCGACTTCGACATCGCATTGTAGATAAATGGC
GAACCTCACTGCAGGTTCGC

Downstream 100 bases:

>100_bases
GTAAAATTTCGACGAAACTGAAGGCCCTCACCGCGGTGCTGTCTGTGACCACTCTGGTGGCTGGGTGTTCCACGCTTCCG
CAGAACACGGATCCGCAAGT

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MLGSIFTASAVVMILLGLGMLTVFTQRLVDQKIDIASSEIDRARVIVEEQITASGASTSVQARVNSARAALSSLGTSGGT
ETNAAYDPVVLVNNDDLVVSPEGYQIPERLRYFVSENQVSYQFSSIDQGDGSSYQALIIGTPTESDIPNLQVYLVFSMES
DESSLALMRGLLSAALLIVVVLLVGIAWLATQQVTAPVRSASRIAERFAQGKLRERMVVEGEDEMARLAVSFNAMAESLS
AQITKLEEYGNLQRQFTSDVSHELRTPLTTVRMAADLIADSEDELSPGARRASQLMNRELDRFESLLSDLLEISRHDAGV
AELSTALHDVRIPVRSALEQVQHLATELDVELLVNLPEEAINIQGDSRRIERIIRNLLANAIDHSKGLPVELKVADNVDA
VAIVVIDHGVGLKPGQDELVFNRFWRADPSRVRHSGGTGLGLAISREDAMLHGGNLDAAGTIGVGSIFRLVLPKEPHGNY
REAPIPLIAPETPWEGEQQ

Sequences:

>Translated_499_residues
MLGSIFTASAVVMILLGLGMLTVFTQRLVDQKIDIASSEIDRARVIVEEQITASGASTSVQARVNSARAALSSLGTSGGT
ETNAAYDPVVLVNNDDLVVSPEGYQIPERLRYFVSENQVSYQFSSIDQGDGSSYQALIIGTPTESDIPNLQVYLVFSMES
DESSLALMRGLLSAALLIVVVLLVGIAWLATQQVTAPVRSASRIAERFAQGKLRERMVVEGEDEMARLAVSFNAMAESLS
AQITKLEEYGNLQRQFTSDVSHELRTPLTTVRMAADLIADSEDELSPGARRASQLMNRELDRFESLLSDLLEISRHDAGV
AELSTALHDVRIPVRSALEQVQHLATELDVELLVNLPEEAINIQGDSRRIERIIRNLLANAIDHSKGLPVELKVADNVDA
VAIVVIDHGVGLKPGQDELVFNRFWRADPSRVRHSGGTGLGLAISREDAMLHGGNLDAAGTIGVGSIFRLVLPKEPHGNY
REAPIPLIAPETPWEGEQQ
>Mature_499_residues
MLGSIFTASAVVMILLGLGMLTVFTQRLVDQKIDIASSEIDRARVIVEEQITASGASTSVQARVNSARAALSSLGTSGGT
ETNAAYDPVVLVNNDDLVVSPEGYQIPERLRYFVSENQVSYQFSSIDQGDGSSYQALIIGTPTESDIPNLQVYLVFSMES
DESSLALMRGLLSAALLIVVVLLVGIAWLATQQVTAPVRSASRIAERFAQGKLRERMVVEGEDEMARLAVSFNAMAESLS
AQITKLEEYGNLQRQFTSDVSHELRTPLTTVRMAADLIADSEDELSPGARRASQLMNRELDRFESLLSDLLEISRHDAGV
AELSTALHDVRIPVRSALEQVQHLATELDVELLVNLPEEAINIQGDSRRIERIIRNLLANAIDHSKGLPVELKVADNVDA
VAIVVIDHGVGLKPGQDELVFNRFWRADPSRVRHSGGTGLGLAISREDAMLHGGNLDAAGTIGVGSIFRLVLPKEPHGNY
REAPIPLIAPETPWEGEQQ

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=312, Percent_Identity=30.1282051282051, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=31.7343173431734, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=29.1814946619217, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=335, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789149, Length=339, Percent_Identity=27.4336283185841, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=28.2700421940928, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=264, Percent_Identity=30.6818181818182, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.9166666666667, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081816, Length=361, Percent_Identity=29.3628808864266, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=27.9310344827586, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788279, Length=252, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=27.4590163934426, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=231, Percent_Identity=31.1688311688312, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=25.5892255892256, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=313, Percent_Identity=23.6421725239617, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=27.9475982532751, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=24.2424242424242, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54190; Mature: 54190

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSIFTASAVVMILLGLGMLTVFTQRLVDQKIDIASSEIDRARVIVEEQITASGASTSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QARVNSARAALSSLGTSGGTETNAAYDPVVLVNNDDLVVSPEGYQIPERLRYFVSENQVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHCCCCEE
YQFSSIDQGDGSSYQALIIGTPTESDIPNLQVYLVFSMESDESSLALMRGLLSAALLIVV
EEECCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VLLVGIAWLATQQVTAPVRSASRIAERFAQGKLRERMVVEGEDEMARLAVSFNAMAESLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHH
AQITKLEEYGNLQRQFTSDVSHELRTPLTTVRMAADLIADSEDELSPGARRASQLMNREL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DRFESLLSDLLEISRHDAGVAELSTALHDVRIPVRSALEQVQHLATELDVELLVNLPEEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHCCCHHH
INIQGDSRRIERIIRNLLANAIDHSKGLPVELKVADNVDAVAIVVIDHGVGLKPGQDELV
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHH
FNRFWRADPSRVRHSGGTGLGLAISREDAMLHGGNLDAAGTIGVGSIFRLVLPKEPHGNY
HHHHHCCCHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCC
REAPIPLIAPETPWEGEQQ
CCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MLGSIFTASAVVMILLGLGMLTVFTQRLVDQKIDIASSEIDRARVIVEEQITASGASTSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QARVNSARAALSSLGTSGGTETNAAYDPVVLVNNDDLVVSPEGYQIPERLRYFVSENQVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHCCCCEE
YQFSSIDQGDGSSYQALIIGTPTESDIPNLQVYLVFSMESDESSLALMRGLLSAALLIVV
EEECCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VLLVGIAWLATQQVTAPVRSASRIAERFAQGKLRERMVVEGEDEMARLAVSFNAMAESLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHH
AQITKLEEYGNLQRQFTSDVSHELRTPLTTVRMAADLIADSEDELSPGARRASQLMNREL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DRFESLLSDLLEISRHDAGVAELSTALHDVRIPVRSALEQVQHLATELDVELLVNLPEEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHCCCHHH
INIQGDSRRIERIIRNLLANAIDHSKGLPVELKVADNVDAVAIVVIDHGVGLKPGQDELV
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCHHHH
FNRFWRADPSRVRHSGGTGLGLAISREDAMLHGGNLDAAGTIGVGSIFRLVLPKEPHGNY
HHHHHCCCHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCC
REAPIPLIAPETPWEGEQQ
CCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]