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The map label for this gene is pepE [H]

Identifier: 59714251

GI number: 59714251

Start: 1204028

End: 1204765

Strand: Reverse

Name: pepE [H]

Synonym: VF_A1068

Alternate gene names: 59714251

Gene position: 1204765-1204028 (Counterclockwise)

Preceding gene: 59714252

Following gene: 59714249

Centisome position: 90.56

GC content: 38.21

Gene sequence:

>738_bases
ATGGATATTTTATTATTAAGTAACGGCAAAATTGCGGGAAATAATCACGTAATGGAGTTTGCAAGTGAAGCGATTATTGA
ACAGATTCAACGCACAAAAGCAAAGAATTTAGTTCTTATTCCTTATGCTGTTATTCGTTCAAGTCATGATGATCGTGTCG
CCTTGGTACAACAAACATTTGATCATCTAGGATTAGATTGTAAAGTAACAGGATTGCATCGTTCAGAAGATCCTGTGAAA
ACCATTCAAGAAGCGGATGGAATTTTGGTTAGCGGTGGCAATACTTGGGTATTAAATAAAACACTGCATGATTTAGGTTT
GATTGGTCCTATTCGTAAAGCTGTACTTGATAATGGCGTTCCATATATCGGTTGGAGTGCAGGCACAAATATTGGTTGCC
CAACGATTCGTACAACGAACGATATGCCTATCATTACTGGCGCTATTCTGCCTTCATTAAATTTAGTTCCATTCCAAATT
AACCCTCATTATTTAGAAGCATCCGTTGAAGGCCATTTTGGTGAAACACGTGATGAGCGTATTCAAGAGTTTTTGGAAGT
GAATAAGCATGAACCTGTAGTTGGTATTCCTGAAGGAACATGGTTGCACATTCTTGATGGTAAGTTGAGCTATCACACCG
CCAATGAAAAACCATTGAAGCTATTCAGTCATGGAAAAGAGCCCGTGTATTATGGCGCTGGAGATGATATTCAATTCTTA
ATGGAACACAGTTGTTAA

Upstream 100 bases:

>100_bases
TTTTTCTGTTATGGTTTTTGCTCTCTCTTGGATCGCTATGCTTATTTTTATAAAAGTAAACATTTGTGGCGATATTAAAT
AGACATAAGGCAGTAAGAAG

Downstream 100 bases:

>100_bases
ATTGTTTTAAGAATACAAATTAAGGCCAAGTCTATTAGTGATTTGGCCTTTGTATTACTTCTCACTTATCTTTAATTTGA
TGTAAGTGATGCCCTGTTTT

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MDILLLSNGKIAGNNHVMEFASEAIIEQIQRTKAKNLVLIPYAVIRSSHDDRVALVQQTFDHLGLDCKVTGLHRSEDPVK
TIQEADGILVSGGNTWVLNKTLHDLGLIGPIRKAVLDNGVPYIGWSAGTNIGCPTIRTTNDMPIITGAILPSLNLVPFQI
NPHYLEASVEGHFGETRDERIQEFLEVNKHEPVVGIPEGTWLHILDGKLSYHTANEKPLKLFSHGKEPVYYGAGDDIQFL
MEHSC

Sequences:

>Translated_245_residues
MDILLLSNGKIAGNNHVMEFASEAIIEQIQRTKAKNLVLIPYAVIRSSHDDRVALVQQTFDHLGLDCKVTGLHRSEDPVK
TIQEADGILVSGGNTWVLNKTLHDLGLIGPIRKAVLDNGVPYIGWSAGTNIGCPTIRTTNDMPIITGAILPSLNLVPFQI
NPHYLEASVEGHFGETRDERIQEFLEVNKHEPVVGIPEGTWLHILDGKLSYHTANEKPLKLFSHGKEPVYYGAGDDIQFL
MEHSC
>Mature_245_residues
MDILLLSNGKIAGNNHVMEFASEAIIEQIQRTKAKNLVLIPYAVIRSSHDDRVALVQQTFDHLGLDCKVTGLHRSEDPVK
TIQEADGILVSGGNTWVLNKTLHDLGLIGPIRKAVLDNGVPYIGWSAGTNIGCPTIRTTNDMPIITGAILPSLNLVPFQI
NPHYLEASVEGHFGETRDERIQEFLEVNKHEPVVGIPEGTWLHILDGKLSYHTANEKPLKLFSHGKEPVYYGAGDDIQFL
MEHSC

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=234, Percent_Identity=42.3076923076923, Blast_Score=170, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24641669, Length=188, Percent_Identity=40.4255319148936, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 27058; Mature: 27058

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILLLSNGKIAGNNHVMEFASEAIIEQIQRTKAKNLVLIPYAVIRSSHDDRVALVQQTF
CEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHHHHHHHHH
DHLGLDCKVTGLHRSEDPVKTIQEADGILVSGGNTWVLNKTLHDLGLIGPIRKAVLDNGV
HHCCCCEEEECCCCCCCHHHHHHHCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCC
PYIGWSAGTNIGCPTIRTTNDMPIITGAILPSLNLVPFQINPHYLEASVEGHFGETRDER
CEEEECCCCCCCCCCEEECCCCCEEEHHHCCCCCEEEEEECCEEEEEEECCCCCCCHHHH
IQEFLEVNKHEPVVGIPEGTWLHILDGKLSYHTANEKPLKLFSHGKEPVYYGAGDDIQFL
HHHHHHCCCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHCCCCCEEECCCCCHHHH
MEHSC
HHCCC
>Mature Secondary Structure
MDILLLSNGKIAGNNHVMEFASEAIIEQIQRTKAKNLVLIPYAVIRSSHDDRVALVQQTF
CEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHHHHHHHHH
DHLGLDCKVTGLHRSEDPVKTIQEADGILVSGGNTWVLNKTLHDLGLIGPIRKAVLDNGV
HHCCCCEEEECCCCCCCHHHHHHHCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCC
PYIGWSAGTNIGCPTIRTTNDMPIITGAILPSLNLVPFQINPHYLEASVEGHFGETRDER
CEEEECCCCCCCCCCEEECCCCCEEEHHHCCCCCEEEEEECCEEEEEEECCCCCCCHHHH
IQEFLEVNKHEPVVGIPEGTWLHILDGKLSYHTANEKPLKLFSHGKEPVYYGAGDDIQFL
HHHHHHCCCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHCCCCCEEECCCCCHHHH
MEHSC
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]