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The map label for this gene is dsbD [H]

Identifier: 59713507

GI number: 59713507

Start: 356822

End: 358108

Strand: Reverse

Name: dsbD [H]

Synonym: VF_A0324

Alternate gene names: 59713507

Gene position: 358108-356822 (Counterclockwise)

Preceding gene: 59713509

Following gene: 59713506

Centisome position: 26.92

GC content: 36.13

Gene sequence:

>1287_bases
ATGACTCTTTTTTTTCTATCGCTTTTTTCAGTTTCTGCGATAGCCCAACCTACTGATGAAATACAATCAAATAATATATT
TAACATTATTGGTATCGCATTATTGGGAGGCTTAATCCTTAATATTATGCCTTGTGTACTGCCGGTTTTAGGTATGAAAT
TGAGCAATATGCTCGCTCTATCCTCTATGAATAGCCAATCTATACGTTTACAATTTTTAGCTTCTGCCTCAGGAATATTG
GTTTCATTTTGGTTACTCGCTTTTAGCGTACTTATTTTAAGAATTACAGGTGGAATGATTGGTTGGGGCATCCAATATCA
AAACCCACTATTTATAGGCTTTATGGCTATCACAATAGGTCTGTTTACAGCTAACCTTTTGGGATTATTCGAAATACAGC
TTTCGCATCGATTTTCAACGTTTATTGCCCAGAAAGGCGACAATTCAACACTCGGAAATTTTATACAAGGGATGTTTGCG
ACACTATTAGCTACACCATGTAGTGCCCCATTTTTAGGAACAGCTATCGCTTTTGCTTTAGGTGCTAGCACATTAGAAAT
GCTATTAATTTTTACTTTCTTAGGATTGGGCATGGCCTTGCCTTGGTTATTCTTTGCTGTTTTTCCTCACTTAATTTCAT
ATATGCCAAAATCAGGCCCATGGATGAACAAAGTCAAAATCGTCTTTGGTTTAATGATGCTGAGTTCAACATTGTGGTTA
TTGAGCTTACTTTCACCATTCATTGGAGTCTTATTAACAGTAATTATTGCCTTACTTTTTAGTATTTATTTACTCTATAA
AATTGCTCATATACATGGAAAAAATACGGTAATCACAATTATTGCTGTCATTATTTTTTTAAGCAGTTCAATACTTATTG
TTGGCAGCATGACCACCAAATATTGGGTTACTCCAACGGAAGATAACTTACGCTGGGAATCATTAGATGAACGTACTATT
GATGACTATGTGAAACAAGGAAAAACCGTCTTTGTTAATGTCAGCGCTGATTGGTGTATTACTTGTAAAACTAATAAAAT
CGGCGTGATATTACAAAACCCTGTCTACCCTGCATTACAGCAAGAAAACGTAATTACCATGCAAGGAGACTGGACTCATC
CAAGCCATAAAATAACGGAGTATTTAAAAAAACACCAACGATATGGCGTTCCTCTGACCGTTGTGTATGGGCCTAATACT
CCACAAGGTCTAACTCTTCCAGTTTTATTAGATGGCGATGAAGTCATTCATGCACTTAATTACGCAAAAGGCAGCTCGAA
TCAATAA

Upstream 100 bases:

>100_bases
CCGCAATAACTTATATCTTTCATATAATTATTTTCGGAGTAAAACCGTGTTTATCATTCAAAAAGTAAAATCGTTCAATC
GATGTCAATTTATCATTTTA

Downstream 100 bases:

>100_bases
TACGGAATAGCAAAACTCAAATCGTTACATTAAAAAGTGAATACCCACTCAAAAAGCTGCTGTTTATTTCTAATCGCAGC
TTTTTCTTTATATTTCACAA

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTLFFLSLFSVSAIAQPTDEIQSNNIFNIIGIALLGGLILNIMPCVLPVLGMKLSNMLALSSMNSQSIRLQFLASASGIL
VSFWLLAFSVLILRITGGMIGWGIQYQNPLFIGFMAITIGLFTANLLGLFEIQLSHRFSTFIAQKGDNSTLGNFIQGMFA
TLLATPCSAPFLGTAIAFALGASTLEMLLIFTFLGLGMALPWLFFAVFPHLISYMPKSGPWMNKVKIVFGLMMLSSTLWL
LSLLSPFIGVLLTVIIALLFSIYLLYKIAHIHGKNTVITIIAVIIFLSSSILIVGSMTTKYWVTPTEDNLRWESLDERTI
DDYVKQGKTVFVNVSADWCITCKTNKIGVILQNPVYPALQQENVITMQGDWTHPSHKITEYLKKHQRYGVPLTVVYGPNT
PQGLTLPVLLDGDEVIHALNYAKGSSNQ

Sequences:

>Translated_428_residues
MTLFFLSLFSVSAIAQPTDEIQSNNIFNIIGIALLGGLILNIMPCVLPVLGMKLSNMLALSSMNSQSIRLQFLASASGIL
VSFWLLAFSVLILRITGGMIGWGIQYQNPLFIGFMAITIGLFTANLLGLFEIQLSHRFSTFIAQKGDNSTLGNFIQGMFA
TLLATPCSAPFLGTAIAFALGASTLEMLLIFTFLGLGMALPWLFFAVFPHLISYMPKSGPWMNKVKIVFGLMMLSSTLWL
LSLLSPFIGVLLTVIIALLFSIYLLYKIAHIHGKNTVITIIAVIIFLSSSILIVGSMTTKYWVTPTEDNLRWESLDERTI
DDYVKQGKTVFVNVSADWCITCKTNKIGVILQNPVYPALQQENVITMQGDWTHPSHKITEYLKKHQRYGVPLTVVYGPNT
PQGLTLPVLLDGDEVIHALNYAKGSSNQ
>Mature_427_residues
TLFFLSLFSVSAIAQPTDEIQSNNIFNIIGIALLGGLILNIMPCVLPVLGMKLSNMLALSSMNSQSIRLQFLASASGILV
SFWLLAFSVLILRITGGMIGWGIQYQNPLFIGFMAITIGLFTANLLGLFEIQLSHRFSTFIAQKGDNSTLGNFIQGMFAT
LLATPCSAPFLGTAIAFALGASTLEMLLIFTFLGLGMALPWLFFAVFPHLISYMPKSGPWMNKVKIVFGLMMLSSTLWLL
SLLSPFIGVLLTVIIALLFSIYLLYKIAHIHGKNTVITIIAVIIFLSSSILIVGSMTTKYWVTPTEDNLRWESLDERTID
DYVKQGKTVFVNVSADWCITCKTNKIGVILQNPVYPALQQENVITMQGDWTHPSHKITEYLKKHQRYGVPLTVVYGPNTP
QGLTLPVLLDGDEVIHALNYAKGSSNQ

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=420, Percent_Identity=25.2380952380952, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 47145; Mature: 47013

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFFLSLFSVSAIAQPTDEIQSNNIFNIIGIALLGGLILNIMPCVLPVLGMKLSNMLAL
CEEEHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSMNSQSIRLQFLASASGILVSFWLLAFSVLILRITGGMIGWGIQYQNPLFIGFMAITIG
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCCEEECCCHHHHHHHHHHH
LFTANLLGLFEIQLSHRFSTFIAQKGDNSTLGNFIQGMFATLLATPCSAPFLGTAIAFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GASTLEMLLIFTFLGLGMALPWLFFAVFPHLISYMPKSGPWMNKVKIVFGLMMLSSTLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LSLLSPFIGVLLTVIIALLFSIYLLYKIAHIHGKNTVITIIAVIIFLSSSILIVGSMTTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCE
YWVTPTEDNLRWESLDERTIDDYVKQGKTVFVNVSADWCITCKTNKIGVILQNPVYPALQ
EEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEEEECCCEEEEECCCCCCCCC
QENVITMQGDWTHPSHKITEYLKKHQRYGVPLTVVYGPNTPQGLTLPVLLDGDEVIHALN
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHH
YAKGSSNQ
HCCCCCCC
>Mature Secondary Structure 
TLFFLSLFSVSAIAQPTDEIQSNNIFNIIGIALLGGLILNIMPCVLPVLGMKLSNMLAL
EEEHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSMNSQSIRLQFLASASGILVSFWLLAFSVLILRITGGMIGWGIQYQNPLFIGFMAITIG
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCCEEECCCHHHHHHHHHHH
LFTANLLGLFEIQLSHRFSTFIAQKGDNSTLGNFIQGMFATLLATPCSAPFLGTAIAFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GASTLEMLLIFTFLGLGMALPWLFFAVFPHLISYMPKSGPWMNKVKIVFGLMMLSSTLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LSLLSPFIGVLLTVIIALLFSIYLLYKIAHIHGKNTVITIIAVIIFLSSSILIVGSMTTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCE
YWVTPTEDNLRWESLDERTIDDYVKQGKTVFVNVSADWCITCKTNKIGVILQNPVYPALQ
EEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEEEECCCEEEEECCCCCCCCC
QENVITMQGDWTHPSHKITEYLKKHQRYGVPLTVVYGPNTPQGLTLPVLLDGDEVIHALN
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHH
YAKGSSNQ
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA